Protein Information

Cytoscape View


UniProt AC / UniProt ID Q92622 / RUBIC_HUMAN
Protein Name Run domain Beclin-1-interacting and cysteine-rich domain-containing protein
Gene Name Name: RUBCN
Synonyms:KIAA0226;
Organism Homo sapiens (Human)

PRO ID PR:Q92622
DAG View
PRO Name Run domain Beclin-1-interacting and cysteine-rich domain-containing protein (human)
Definition A protein that is a translation product of the RUBCN gene in human.
Short Label hRUBCN
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q92622 (RUBCN) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S44 Phosphorylation PhosphoSitePlus
K50 Ubiquitination PhosphoSitePlus
S92 Phosphorylation PhosphoSitePlus
K194 Ubiquitination PhosphoSitePlus
S197 Phosphorylation PhosphoSitePlus   UniProt 18691976, 23186163, 19369195
S246 Phosphorylation PhosphoSitePlus
T247 Phosphorylation PhosphoSitePlus
S248 Phosphorylation PhosphoSitePlus   UniProt 23186163
S266 Phosphorylation PhosphoSitePlus   UniProt 19369195, 23186163
T272 Phosphorylation PhosphoSitePlus
S378 Phosphorylation PhosphoSitePlus
S387 Phosphorylation PhosphoSitePlus
S388 Phosphorylation PhosphoSitePlus   UniProt 23186163
S390 Phosphorylation PhosphoSitePlus
K403 Ubiquitination PhosphoSitePlus
S408 Phosphorylation PhosphoSitePlus
S410 Phosphorylation PhosphoSitePlus
S416 Phosphorylation PhosphoSitePlus
T444 Phosphorylation PhosphoSitePlus
Y449 Phosphorylation PhosphoSitePlus
Y457 Phosphorylation PhosphoSitePlus
S469 Phosphorylation PhosphoSitePlus
S473 Phosphorylation PhosphoSitePlus
S479 Phosphorylation PhosphoSitePlus
S528 Phosphorylation PhosphoSitePlus   UniProt 19369195
S562 Phosphorylation PhosphoSitePlus   UniProt 23186163
S570 Phosphorylation PhosphoSitePlus
S577 Phosphorylation PhosphoSitePlus
S581 Phosphorylation PhosphoSitePlus
S583 Phosphorylation PhosphoSitePlus
S585 Phosphorylation PhosphoSitePlus
S609 Phosphorylation PhosphoSitePlus
S612 Phosphorylation PhosphoSitePlus
S615 Phosphorylation PhosphoSitePlus
K660 Ubiquitination PhosphoSitePlus
S671 Phosphorylation PhosphoSitePlus   UniProt 18691976, 19690332
K682 Ubiquitination PhosphoSitePlus
T709 Phosphorylation PhosphoSitePlus
K716 Ubiquitination PhosphoSitePlus
T728 Phosphorylation PhosphoSitePlus
Y732 Phosphorylation PhosphoSitePlus
K734 Ubiquitination PhosphoSitePlus
Y772 Phosphorylation PhosphoSitePlus
S774 Phosphorylation PhosphoSitePlus
S777 Phosphorylation PhosphoSitePlus
K778 Ubiquitination PhosphoSitePlus
K830 Ubiquitination PhosphoSitePlus
S851 Phosphorylation PhosphoSitePlus
T856 Phosphorylation PhosphoSitePlus
K860 Ubiquitination PhosphoSitePlus
K921 Ubiquitination PhosphoSitePlus
S952 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S197 Phosphorylation HPRD 18691976
S266 Phosphorylation HPRD 18691976
T272 Phosphorylation HPRD 18691976
S410 Phosphorylation HPRD 18691976
S577 Phosphorylation HPRD 18691976
S581 Phosphorylation HPRD 18691976
S583 Phosphorylation HPRD 18691976
S585 Phosphorylation HPRD 18691976
S667 Phosphorylation HPRD 18691976
S671 Phosphorylation HPRD 18691976


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S266 L266 Biomuta DOID:4362 / cervical cancer [ cosmic, icgc, tcga ]
S410 L410 Biomuta DOID:363 / uterine cancer [ cosmic, icgc, tcga ] DOID:9256 / colorectal cancer [ tcga ] DOID:1909 / melanoma [ cosmic, tcga ]
S473 Y473 Biomuta DOID:3571 / liver cancer [ icgc ]
S609 P609 Biomuta DOID:1909 / melanoma [ cosmic ]
T728 N728 Biomuta DOID:3571 / liver cancer [ icgc ]
Y772 * Biomuta DOID:3571 / liver cancer [ icgc ]