iPTMnet Report for Q92622 (RUBCN)
Protein Information
| UniProt AC / UniProt ID | Q92622 / RUBIC_HUMAN |
| Protein Name | Run domain Beclin-1-interacting and cysteine-rich domain-containing protein |
| Gene Name | Name: RUBCN Synonyms:KIAA0226; |
| Organism | Homo sapiens (Human) |
| PRO ID | PR:Q92622 |
| PRO Name | Run domain Beclin-1-interacting and cysteine-rich domain-containing protein (human) |
| Definition | A Run domain Beclin-1-interacting and cysteine-rich domain-containing protein that is encoded in the genome of human. |
| Short Label | hRUBCN |
| Category | organism-gene |
Q92622 (RUBCN) as Substrate
| Site | PTM Type | PTM Enzyme | Score | Source | PMID | |
|---|---|---|---|---|---|---|
| S44 | Phosphorylation | score3 | PhosphoSitePlus RLIMS-P | 31752345 | ||
| K50 | Ubiquitination | score1 | PhosphoSitePlus | |||
| S92 | Phosphorylation | score3 | PhosphoSitePlus RLIMS-P | 31752345 | ||
| K194 | Ubiquitination | score1 | PhosphoSitePlus | |||
| S197 | Phosphorylation | score2 | PhosphoSitePlus UniProt | 18691976, 23186163, 19369195 | ||
| S246 | Phosphorylation | score1 | PhosphoSitePlus | |||
| T247 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S248 | Phosphorylation | score2 | PhosphoSitePlus UniProt | 23186163 | ||
| S266 | Phosphorylation | score2 | PhosphoSitePlus UniProt | 19369195, 23186163 | ||
| T272 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S378 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S387 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S388 | Phosphorylation | score2 | PhosphoSitePlus UniProt | 23186163 | ||
| S390 | Phosphorylation | score1 | PhosphoSitePlus | |||
| K403 | Ubiquitination | score1 | PhosphoSitePlus | |||
| S408 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S410 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S416 | Phosphorylation | score1 | PhosphoSitePlus | |||
| T444 | Phosphorylation | score1 | PhosphoSitePlus | |||
| Y449 | Phosphorylation | score1 | PhosphoSitePlus | |||
| Y457 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S469 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S473 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S479 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S528 | Phosphorylation | score2 | PhosphoSitePlus UniProt | 19369195 | ||
| S562 | Phosphorylation | score2 | PhosphoSitePlus UniProt | 23186163 | ||
| S570 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S577 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S581 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S583 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S585 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S609 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S612 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S615 | Phosphorylation | score1 | PhosphoSitePlus | |||
| K660 | Ubiquitination | score1 | PhosphoSitePlus | |||
| S671 | Phosphorylation | score2 | PhosphoSitePlus UniProt | 18691976, 19690332 | ||
| K682 | Ubiquitination | score1 | PhosphoSitePlus | |||
| T709 | Phosphorylation | score1 | PhosphoSitePlus | |||
| K716 | Ubiquitination | score1 | PhosphoSitePlus | |||
| T728 | Phosphorylation | score1 | PhosphoSitePlus | |||
| Y732 | Phosphorylation | score1 | PhosphoSitePlus | |||
| K734 | Ubiquitination | score1 | PhosphoSitePlus | |||
| Y772 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S774 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S777 | Phosphorylation | score1 | PhosphoSitePlus | |||
| K778 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K830 | Ubiquitination | score1 | PhosphoSitePlus | |||
| S851 | Phosphorylation | score1 | PhosphoSitePlus | |||
| T856 | Phosphorylation | score1 | PhosphoSitePlus | |||
| K860 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K921 | Ubiquitination | score1 | PhosphoSitePlus | |||
| S952 | Phosphorylation | score1 | PhosphoSitePlus |
| Site | PTM Type | PTM Enzyme | Score | Source | PMID | |
|---|---|---|---|---|---|---|
| S197 | Phosphorylation | score0 | HPRD | 18691976 | ||
| S266 | Phosphorylation | score0 | HPRD | 18691976 | ||
| T272 | Phosphorylation | score0 | HPRD | 18691976 | ||
| S410 | Phosphorylation | score0 | HPRD | 18691976 | ||
| S577 | Phosphorylation | score0 | HPRD | 18691976 | ||
| S581 | Phosphorylation | score0 | HPRD | 18691976 | ||
| S583 | Phosphorylation | score0 | HPRD | 18691976 | ||
| S585 | Phosphorylation | score0 | HPRD | 18691976 | ||
| S667 | Phosphorylation | score0 | HPRD | 18691976 | ||
| S671 | Phosphorylation | score0 | HPRD | 18691976 |
PTM sites affected in variants
| Site | Variant | Source | PMID | Disease [Sample source] |
|---|---|---|---|---|
| S92 | N92 | Biomuta | DOID:4606 / bile duct cancer [ cosmic ] | |
| S197 | R197 | Biomuta | DOID:1324 / lung cancer [ cosmic, icgc ] | |
| S266 | L266 | Biomuta | DOID:4362 / cervical cancer [ cosmic, icgc ] | |
| S410 | L410 | Biomuta | DOID:363 / uterine cancer [ cosmic, icgc ] DOID:4159 / skin cancer [ cosmic, icgc ] DOID:8618 / oral cavity cancer [ cosmic ] DOID:9256 / colorectal cancer [ cosmic, tcga ] | |
| S562 | I562 | Biomuta | DOID:3953 / adrenal gland cancer [ cosmic ] | |
| S609 | F609 | Biomuta | DOID:4159 / skin cancer [ cosmic ] | |
| S609 | P609 | Biomuta | DOID:9256 / colorectal cancer [ cosmic ] | |
| T709 | M709 | Biomuta | DOID:9253 / gastrointestinal stromal tumor [ cosmic ] | |
| K778 | N778 | Biomuta | DOID:9256 / colorectal cancer [ cosmic ] | |
| K778 | E778 | Biomuta | DOID:3571 / liver cancer [ cosmic ] | |
| S851 | L851 | Biomuta | DOID:2531 / hematologic cancer [ cosmic ] | |
| K860 | * | Biomuta | DOID:263 / kidney cancer [ cosmic ] |
DAG View