iPTMnet Report for Q92620 (DHX38)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q92620 / PRP16_HUMAN
Protein Name Pre-mRNA-splicing factor ATP-dependent RNA helicase PRP16
Gene Name Name: DHX38
Synonyms:DDX38,KIAA0224,PRP16;
Organism Homo sapiens (Human)

PRO ID PR:Q92620
DAG View
PRO Name pre-mRNA-splicing factor ATP-dependent RNA helicase PRP16 (human)
Definition A pre-mRNA-splicing factor ATP-dependent RNA helicase PRP16 that is encoded in the genome of human.
Short Label hDHX38
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q92620 (DHX38) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
G2 Acetylation UniProt 19413330
S47 Phosphorylation PhosphoSitePlus
S56 Phosphorylation PhosphoSitePlus   UniProt 23186163
K58 Acetylation PhosphoSitePlus
T117 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 23186163, 18220336
Y145 Phosphorylation PhosphoSitePlus
K149 Sumoylation PhosphoSitePlus
S180 Phosphorylation PhosphoSitePlus
S182 O-Glycosylation GlyGen 30379171, 31492838, 28510447, ...34725712, 34019948
S188 O-Glycosylation GlyGen 30379171, 31492838, 28510447, ...34725712, 34019948
S199 Phosphorylation PhosphoSitePlus   UniProt 20068231
S224 Phosphorylation PhosphoSitePlus   UniProt 23186163
S232 Phosphorylation P24941 (CDK2) PhosphoSitePlus 18847512
S234 Phosphorylation P24941 (CDK2) PhosphoSitePlus 18847512
T236 Phosphorylation PhosphoSitePlus
S242 Phosphorylation PhosphoSitePlus
S256 Phosphorylation PhosphoSitePlus
K260 Acetylation PhosphoSitePlus   UniProt 19608861
K260 Methylation PhosphoSitePlus
T265 Phosphorylation PhosphoSitePlus
T269 Phosphorylation PhosphoSitePlus
Y272 Phosphorylation PhosphoSitePlus
T287 Phosphorylation PhosphoSitePlus
R289 Methylation PhosphoSitePlus
S291 Phosphorylation PhosphoSitePlus
T384 Phosphorylation PhosphoSitePlus
K425 Sumoylation PhosphoSitePlus
K425 Ubiquitination PhosphoSitePlus
K434 Ubiquitination PhosphoSitePlus
S448 Phosphorylation PhosphoSitePlus
K466 Ubiquitination PhosphoSitePlus
K482 Sumoylation PhosphoSitePlus
K504 Sumoylation PhosphoSitePlus
K504 Ubiquitination PhosphoSitePlus
K510 Ubiquitination PhosphoSitePlus
S513 Phosphorylation PhosphoSitePlus
K521 Acetylation PhosphoSitePlus
K595 Ubiquitination PhosphoSitePlus
K679 Acetylation PhosphoSitePlus
T708 Phosphorylation PhosphoSitePlus
K793 Ubiquitination PhosphoSitePlus
T805 Phosphorylation PhosphoSitePlus
C826 Methylation IEDB 31844290
K829 Ubiquitination PhosphoSitePlus
T860 Phosphorylation PhosphoSitePlus
K875 Ubiquitination PhosphoSitePlus
K1049 Ubiquitination PhosphoSitePlus
S1058 Phosphorylation PhosphoSitePlus
T1064 Phosphorylation PhosphoSitePlus
K1083 Acetylation PhosphoSitePlus
K1166 Sumoylation PhosphoSitePlus
K1166 Ubiquitination PhosphoSitePlus
S1194 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648
S1198 Phosphorylation PhosphoSitePlus
T1206 Phosphorylation PhosphoSitePlus
T1217 Phosphorylation PhosphoSitePlus
T1221 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S180 Phosphorylation HPRD 20068231
S199 Phosphorylation HPRD 20068231
T287 Phosphorylation HPRD 18212344, 20068231
S1058 Phosphorylation HPRD 18491316
S1194 Phosphorylation HPRD 19651622, 18669648
Site PTM Type PTM Enzyme Score Source PMID
K101 Sumoylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S199 G199 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S234 F234 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
T265 M265 Biomuta DOID:3565 / meningioma [ cosmic ]
S291 P291 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S513 I513 Biomuta DOID:363 / uterine cancer [ icgc ]
K521 N521 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
K595 N595 Biomuta DOID:1324 / lung cancer [ cosmic ]
T860 M860 Biomuta [ cosmic ] DOID:1115 / sarcoma [ icgc, tcga ]
K1049 N1049 Biomuta DOID:1324 / lung cancer [ cosmic ]
K1049 R1049 Biomuta DOID:10283 / prostate cancer [ cosmic, icgc ]