iPTMnet Report for Q92619 (ARHGAP45)
Protein Information
UniProt AC / UniProt ID | Q92619 / HMHA1_HUMAN |
Protein Name | Rho GTPase-activating protein 45 |
Gene Name | Name: ARHGAP45 Synonyms:HMHA1; |
Organism | Homo sapiens (Human) |
PRO ID | PR:Q92619 |
PRO Name | Rho GTPase-activating protein 45 (human) |
Definition | A Rho GTPase-activating protein 45 that is encoded in the genome of human. |
Short Label | hARHGAP45 |
Category | organism-gene |
Q92619 (ARHGAP45) as Substrate
Site | PTM Type | PTM Enzyme | Score | Source | PMID | |
---|---|---|---|---|---|---|
T12 | Phosphorylation | score1 | PhosphoSitePlus | |||
S14 | Phosphorylation | score1 | PhosphoSitePlus | |||
S23 | Phosphorylation | score2 | PhosphoSitePlus UniProt | 23186163, 16964243, 24275569, ... | ||
S25 | Phosphorylation | score2 | PhosphoSitePlus UniProt | 16964243 | ||
S29 | Phosphorylation | score1 | PhosphoSitePlus | |||
T61 | Phosphorylation | score1 | PhosphoSitePlus | |||
T66 | Phosphorylation | score1 | PhosphoSitePlus | |||
S67 | Phosphorylation | score1 | PhosphoSitePlus | |||
S69 | Phosphorylation | score1 | PhosphoSitePlus | |||
S73 | Phosphorylation | score2 | PhosphoSitePlus UniProt | 23186163, 19690332 | ||
S80 | Phosphorylation | score1 | PhosphoSitePlus | |||
S84 | Phosphorylation | score1 | PhosphoSitePlus | |||
T86 | Phosphorylation | score1 | PhosphoSitePlus | |||
S90 | Phosphorylation | score1 | PhosphoSitePlus | |||
S93 | Phosphorylation | score2 | PhosphoSitePlus UniProt | 19690332 | ||
T96 | Phosphorylation | score1 | PhosphoSitePlus | |||
S99 | Phosphorylation | score2 | PhosphoSitePlus UniProt | 19367720, 19690332 | ||
T105 | Phosphorylation | score1 | PhosphoSitePlus | |||
K132 | Ubiquitination | score1 | PhosphoSitePlus | |||
K134 | Ubiquitination | score1 | PhosphoSitePlus | |||
K188 | Ubiquitination | score1 | PhosphoSitePlus | |||
S194 | Phosphorylation | score1 | PhosphoSitePlus | |||
Y295 | Phosphorylation | score1 | PhosphoSitePlus | |||
K305 | Acetylation | score1 | PhosphoSitePlus | |||
K394 | Ubiquitination | score1 | PhosphoSitePlus | |||
S439 | Phosphorylation | score1 | PhosphoSitePlus | |||
T440 | Phosphorylation | score1 | PhosphoSitePlus | |||
T442 | Phosphorylation | score1 | PhosphoSitePlus | |||
T444 | Phosphorylation | score1 | PhosphoSitePlus | |||
T465 | Phosphorylation | score1 | PhosphoSitePlus | |||
Y466 | Phosphorylation | score1 | PhosphoSitePlus | |||
T468 | Phosphorylation | score1 | PhosphoSitePlus | |||
K474 | Ubiquitination | score1 | PhosphoSitePlus | |||
K477 | Acetylation | score1 | PhosphoSitePlus | |||
K484 | Ubiquitination | score1 | PhosphoSitePlus | |||
Y540 | Phosphorylation | score1 | PhosphoSitePlus | |||
Y557 | Phosphorylation | score1 | PhosphoSitePlus | |||
S564 | Phosphorylation | score1 | PhosphoSitePlus | |||
S569 | Phosphorylation | score2 | PhosphoSitePlus UniProt | 19367720, 23186163, 19690332, ... | ||
S577 | Phosphorylation | score1 | PhosphoSitePlus | |||
S578 | Phosphorylation | score2 | PhosphoSitePlus UniProt | 24275569 | ||
S582 | Phosphorylation | score1 | PhosphoSitePlus | |||
S592 | Phosphorylation | score2 | PhosphoSitePlus UniProt | 23186163 | ||
T600 | Phosphorylation | score1 | PhosphoSitePlus | |||
T603 | Phosphorylation | score1 | PhosphoSitePlus | |||
S619 | Phosphorylation | score2 | PhosphoSitePlus UniProt | 19690332, 24275569 | ||
S623 | Phosphorylation | score1 | PhosphoSitePlus | |||
S625 | Phosphorylation | score1 | PhosphoSitePlus | |||
S627 | Phosphorylation | score1 | PhosphoSitePlus | |||
S629 | Phosphorylation | score1 | PhosphoSitePlus | |||
K737 | Ubiquitination | score1 | PhosphoSitePlus | |||
K738 | Ubiquitination | score1 | PhosphoSitePlus | |||
K816 | Ubiquitination | score1 | PhosphoSitePlus | |||
K834 | Ubiquitination | score1 | PhosphoSitePlus | |||
K858 | Ubiquitination | score1 | PhosphoSitePlus | |||
K862 | Ubiquitination | score1 | PhosphoSitePlus | |||
T947 | Phosphorylation | score1 | PhosphoSitePlus | |||
S949 | Phosphorylation | score2 | PhosphoSitePlus UniProt | 24275569 | ||
S951 | Phosphorylation | score1 | PhosphoSitePlus | |||
S952 | Phosphorylation | score1 | PhosphoSitePlus | |||
S1032 | Phosphorylation | score1 | PhosphoSitePlus | |||
S1127 | Phosphorylation | score1 | PhosphoSitePlus |
Site | PTM Type | PTM Enzyme | Score | Source | PMID | |
---|---|---|---|---|---|---|
S23 | Phosphorylation | score0 | HPRD | 20058876, 16964243 | ||
S25 | Phosphorylation | score0 | HPRD | 20058876, 16964243 | ||
S73 | Phosphorylation | score0 | HPRD | 20058876 | ||
S569 | Phosphorylation | score0 | HPRD | 20166139 | ||
S577 | Phosphorylation | score0 | HPRD | 20058876 | ||
S578 | Phosphorylation | score0 | HPRD | 20166139, 20058876 | ||
S952 | Phosphorylation | score0 | HPRD | 20058876 |
PTM sites affected in variants
Site | Variant | Source | PMID | Disease [Sample source] |
---|---|---|---|---|
S25 | I25 | Biomuta | DOID:3571 / liver cancer [ icgc ] | |
T61 | S61 | Biomuta | DOID:2394 / ovarian cancer [ icgc ] | |
S69 | G69 | Biomuta | DOID:3963 / thyroid carcinoma [ cosmic, icgc ] | |
S194 | I194 | Biomuta | DOID:363 / uterine cancer [ tcga ] | |
S439 | G439 | Biomuta | DOID:9256 / colorectal cancer [ icgc ] | |
K477 | R477 | Biomuta | DOID:10534 / stomach cancer [ cosmic, icgc, tcga ] | |
Y540 | H540 | Biomuta | DOID:363 / uterine cancer [ tcga ] DOID:9256 / colorectal cancer [ icgc, tcga ] DOID:1909 / melanoma [ cosmic ] | |
S578 | G578 | Biomuta | DOID:10534 / stomach cancer [ tcga ] | |
S623 | L623 | Biomuta | DOID:9256 / colorectal cancer [ tcga ] DOID:1909 / melanoma [ cosmic ] | |
S625 | * | Biomuta | DOID:4362 / cervical cancer [ icgc, tcga ] | |
S629 | R629 | Biomuta | DOID:2394 / ovarian cancer [ icgc ] DOID:2994 / germ cell cancer [ cosmic ] | |
K862 | E862 | Biomuta | DOID:3963 / thyroid carcinoma [ cosmic, icgc ] | |
S951 | C951 | Biomuta | DOID:263 / kidney cancer [ tcga ] |