iPTMnet Report for Q92614 (MYO18A)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q92614 / MY18A_HUMAN
Protein Name Unconventional myosin-XVIIIa
Gene Name Name: MYO18A
Synonyms:CD245;
Organism Homo sapiens (Human)

PRO ID PR:Q92614
DAG View
PRO Name unconventional myosin-XVIIIa (human)
Definition A myosin-XVIIIa that is encoded in the genome of human.
Short Label hMYO18A
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q92614 (MYO18A) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S29 Phosphorylation PhosphoSitePlus
S35 Phosphorylation PhosphoSitePlus   UniProt 23186163
S40 Phosphorylation PhosphoSitePlus
R43 Methylation PhosphoSitePlus
S51 Phosphorylation PhosphoSitePlus
S52 Phosphorylation PhosphoSitePlus   UniProt 23186163
S56 Phosphorylation PhosphoSitePlus
S63 Phosphorylation PhosphoSitePlus
S72 Phosphorylation PhosphoSitePlus   UniProt 23186163
S74 Phosphorylation PhosphoSitePlus   UniProt 23186163
T79 Phosphorylation PhosphoSitePlus   UniProt 24275569
S83 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163, 20068231
S85 Phosphorylation PhosphoSitePlus
S89 Phosphorylation PhosphoSitePlus
S94 Phosphorylation PhosphoSitePlus
S98 Phosphorylation PhosphoSitePlus   UniProt 24275569
T99 Phosphorylation PhosphoSitePlus   UniProt 24275569
S101 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S102 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S103 Phosphorylation PhosphoSitePlus   UniProt 24275569
S112 Phosphorylation PhosphoSitePlus
S116 Phosphorylation PhosphoSitePlus
S126 Phosphorylation PhosphoSitePlus
S132 Phosphorylation PhosphoSitePlus
K137 Acetylation PhosphoSitePlus
S140 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 21406692, 17081983, 18220336, ...24275569, 20068231
S142 Phosphorylation PhosphoSitePlus
S145 Phosphorylation PhosphoSitePlus   UniProt 23186163
S149 Phosphorylation PhosphoSitePlus
S151 Phosphorylation PhosphoSitePlus
T153 Phosphorylation PhosphoSitePlus
S154 Phosphorylation PhosphoSitePlus
T155 Phosphorylation PhosphoSitePlus
S157 Phosphorylation PhosphoSitePlus
S160 Phosphorylation PhosphoSitePlus
S164 Phosphorylation PhosphoSitePlus   UniProt 23186163
S191 Phosphorylation PhosphoSitePlus
T217 Phosphorylation PhosphoSitePlus
T228 Phosphorylation PhosphoSitePlus
S234 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 23186163, 17081983, 24275569
K335 Ubiquitination PhosphoSitePlus
K351 Ubiquitination PhosphoSitePlus
K367 Ubiquitination PhosphoSitePlus
K377 Ubiquitination PhosphoSitePlus
K381 Ubiquitination PhosphoSitePlus
K398 Ubiquitination PhosphoSitePlus
Y415 Phosphorylation PhosphoSitePlus
Y454 Phosphorylation PhosphoSitePlus
S455 Phosphorylation PhosphoSitePlus
K457 Acetylation PhosphoSitePlus
K463 Methylation PhosphoSitePlus
K463 Ubiquitination PhosphoSitePlus
S493 Phosphorylation PhosphoSitePlus
K637 Ubiquitination PhosphoSitePlus
K644 Ubiquitination PhosphoSitePlus
K650 Ubiquitination PhosphoSitePlus
K719 Ubiquitination PhosphoSitePlus
T722 Phosphorylation PhosphoSitePlus
S726 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
T727 Phosphorylation PhosphoSitePlus
S728 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S736 Phosphorylation PhosphoSitePlus
Y835 Phosphorylation PhosphoSitePlus
Y904 Phosphorylation PhosphoSitePlus
Y905 Phosphorylation PhosphoSitePlus
K913 Ubiquitination PhosphoSitePlus
S916 Phosphorylation PhosphoSitePlus
S965 Phosphorylation PhosphoSitePlus
K967 Sumoylation PhosphoSitePlus
K968 Sumoylation PhosphoSitePlus
S971 Phosphorylation PhosphoSitePlus
S980 Phosphorylation PhosphoSitePlus
S985 Phosphorylation PhosphoSitePlus
S987 Phosphorylation PhosphoSitePlus
S995 Phosphorylation PhosphoSitePlus
S1004 Phosphorylation PhosphoSitePlus
T1008 Phosphorylation PhosphoSitePlus
K1017 Ubiquitination PhosphoSitePlus
K1037 Ubiquitination PhosphoSitePlus
K1038 Ubiquitination PhosphoSitePlus
S1039 Phosphorylation PhosphoSitePlus
S1060 Phosphorylation PhosphoSitePlus
S1062 Phosphorylation PhosphoSitePlus
S1063 Phosphorylation PhosphoSitePlus
S1067 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 17081983, 24275569, ...18220336
S1068 Phosphorylation PhosphoSitePlus   UniProt 24275569
S1069 Phosphorylation phospho.ELM   PhosphoSitePlus 18220336
S1070 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 17081983
S1076 Phosphorylation PhosphoSitePlus
S1099 Phosphorylation PhosphoSitePlus
Y1140 Phosphorylation PhosphoSitePlus
S1284 Phosphorylation PhosphoSitePlus
S1309 Phosphorylation PhosphoSitePlus
K1386 Ubiquitination PhosphoSitePlus
T1442 Phosphorylation PhosphoSitePlus
S1465 Phosphorylation PhosphoSitePlus
S1468 Phosphorylation PhosphoSitePlus
Q1501 Phosphorylation UniProt 24275569
S1518 Phosphorylation PhosphoSitePlus
R1583 Methylation PhosphoSitePlus
K1635 Ubiquitination PhosphoSitePlus
S1640 Phosphorylation PhosphoSitePlus   UniProt 23186163, 24275569
T1728 Phosphorylation PhosphoSitePlus
S1843 Phosphorylation PhosphoSitePlus   UniProt 23186163
S1910 Phosphorylation PhosphoSitePlus
L1922 Phosphorylation UniProt 24275569
S1942 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 17081983, 24275569
S1951 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
Y1959 Phosphorylation UniProt 24275569
S1970 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 21406692, 23186163, 17081983, ...18318008, 18669648, 24275569
S1974 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 17081983, 24275569, ...18318008
S1998 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 15302935, 24275569
S2002 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 24275569
S2005 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S2006 Phosphorylation PhosphoSitePlus   UniProt 24275569
S2007 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163, 21406692
T2009 Phosphorylation PhosphoSitePlus
S2014 Phosphorylation PhosphoSitePlus   UniProt 24275569
S2020 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 23186163, 17081983, 18220336, ...18669648, 24275569, 18088087
T2030 Phosphorylation PhosphoSitePlus
Y2035 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 24275569
S2036 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S2038 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
Y2039 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S2041 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 21406692, 16083285, 23186163, ...17081983, 18669648, 24275569, 18088087, 19690332, 20068231
S2043 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 21406692, 16083285, 18088087, ...17081983, 18669648, 24275569, 23186163, 19690332, 20068231
T2045 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648
T2050 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S72 Phosphorylation HPRD 19651622, 20166139
S74 Phosphorylation HPRD 20166139
S83 Phosphorylation HPRD 19651622, 18669648, 20068231
S94 Phosphorylation HPRD 19651622
S98 Phosphorylation HPRD 20166139, 20068231
T99 Phosphorylation HPRD 20068231
S101 Phosphorylation HPRD 20166139, 18669648
S102 Phosphorylation HPRD 20166139, 18669648
S140 Phosphorylation HPRD 17322306, 18767875, 20166139, ...20068231
S145 Phosphorylation HPRD 20166139
T153 Phosphorylation HPRD 20166139
S234 Phosphorylation HPRD 17081983
S726 Phosphorylation HPRD 18669648
S728 Phosphorylation HPRD 18669648
S1067 Phosphorylation HPRD 20166139, 18669648, 20068231
S1068 Phosphorylation HPRD 17081983
S1069 Phosphorylation HPRD 17081983
S1070 Phosphorylation HPRD 18669648, 20068231
S1640 Phosphorylation HPRD 20068231
S1942 Phosphorylation HPRD 17081983, 18452278
S1970 Phosphorylation HPRD 17081983, 18452278, 19651622, ...18669648, 20166139, 20068231
S1974 Phosphorylation HPRD 19651622, 18669648, 17081983, ...20068231
S1998 Phosphorylation HPRD 19651622, 20166139, 18669648, ...15302935
S2002 Phosphorylation HPRD 19651622, 20166139, 18669648
S2005 Phosphorylation HPRD 20166139, 18669648, 20068231
S2006 Phosphorylation HPRD 20166139
S2007 Phosphorylation HPRD 19413330, 18767875, 18669648, ...20166139, 20068231
S2014 Phosphorylation HPRD 19651622
S2020 Phosphorylation HPRD 18088087, 17081983, 18452278, ...19651622, 18669648, 20166139, 20068231
Y2035 Phosphorylation HPRD 18669648, 20068231
S2036 Phosphorylation HPRD 18669648, 20068231
S2038 Phosphorylation HPRD 18669648, 17081983
Y2039 Phosphorylation HPRD 18669648, 17081983
S2041 Phosphorylation HPRD 16083285, 18088087, 18767875, ...18452278, 19651622, 18669648, 20166139, 20068231
S2043 Phosphorylation HPRD 16083285, 18088087, 18767875, ...18452278, 19651622, 18669648, 20166139, 20068231
T2045 Phosphorylation HPRD 18669648, 17081983, 20068231
Site PTM Type PTM Enzyme Score Source PMID
S729 Phosphorylation PhosphoSitePlus
S1639 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S1905 Phosphorylation PhosphoSitePlus
S1914 Phosphorylation PhosphoSitePlus
S1918 Phosphorylation PhosphoSitePlus
S1922 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S72 Phosphorylation HPRD 19651622, 20166139
S74 Phosphorylation HPRD 20166139
S83 Phosphorylation HPRD   phospho.ELM 19651622, 18669648, 20068231
S94 Phosphorylation HPRD 19651622
S98 Phosphorylation HPRD 20166139, 20068231
T99 Phosphorylation HPRD 20068231
S101 Phosphorylation HPRD   phospho.ELM 20166139, 18669648
S102 Phosphorylation HPRD   phospho.ELM 20166139, 18669648
S140 Phosphorylation HPRD   phospho.ELM 17322306, 18767875, 20166139, ...20068231, 18220336
S145 Phosphorylation HPRD 20166139
T153 Phosphorylation HPRD 20166139
S234 Phosphorylation HPRD 17081983
S726 Phosphorylation HPRD   phospho.ELM 18669648
S728 Phosphorylation HPRD   phospho.ELM 18669648
S1062 Phosphorylation PhosphoSitePlus
S1063 Phosphorylation PhosphoSitePlus
S1067 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 20166139, 18669648, 20068231, ...18220336
S1068 Phosphorylation HPRD   PhosphoSitePlus 17081983
S1069 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 17081983, 18220336
S1070 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 18669648, 20068231
S1076 Phosphorylation PhosphoSitePlus
S1284 Phosphorylation PhosphoSitePlus
S1640 Phosphorylation HPRD 20068231
S1942 Phosphorylation HPRD   PhosphoSitePlus 18669648, 18452278
S1951 Phosphorylation HPRD   PhosphoSitePlus 18669648, 18452278
S1955 Phosphorylation HPRD   PhosphoSitePlus 18669648, 18452278
S1959 Phosphorylation HPRD   PhosphoSitePlus 18669648, 18452278
S1983 Phosphorylation HPRD 19651622, 20166139, 18669648, ...15302935
S1987 Phosphorylation HPRD 19651622, 20166139, 18669648
S1990 Phosphorylation HPRD   phospho.ELM 20166139, 18669648, 20068231, ...18220336
S1991 Phosphorylation HPRD 20166139
S1992 Phosphorylation HPRD 19413330, 18767875, 18669648, ...20166139, 20068231
S1999 Phosphorylation HPRD 19651622
S2005 Phosphorylation HPRD 18088087, 17081983, 18452278, ...19651622, 18669648, 20166139, 20068231
T2015 Phosphorylation phospho.ELM 18669648
Y2020 Phosphorylation HPRD 18669648, 20068231
S2021 Phosphorylation HPRD 18669648, 20068231
S2023 Phosphorylation HPRD 18669648, 17081983
Y2024 Phosphorylation HPRD 18669648, 17081983
S2026 Phosphorylation HPRD 16083285, 18088087, 18767875, ...18452278, 19651622, 18669648, 20166139, 20068231
S2028 Phosphorylation HPRD 16083285, 18088087, 18767875, ...18452278, 19651622, 18669648, 20166139, 20068231
T2030 Phosphorylation HPRD 18669648, 17081983, 20068231


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S35 I35 Biomuta DOID:1793 / pancreatic cancer [ icgc ]
S35 R35 Biomuta [ cosmic ] DOID:1115 / sarcoma [ icgc ]
R43 H43 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
S51 F51 Biomuta DOID:8618 / oral cavity cancer [ cosmic ] DOID:11934 / head and neck cancer [ icgc ]
S51 P51 Biomuta DOID:8618 / oral cavity cancer [ cosmic ]
S52 F52 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
S56 C56 Biomuta DOID:1324 / lung cancer [ cosmic ]
S56 F56 Biomuta DOID:4159 / skin cancer [ cosmic ]
S94 L94 Biomuta DOID:10534 / stomach cancer [ cosmic ]
S102 C102 Biomuta DOID:1324 / lung cancer [ cosmic ]
S103 R103 Biomuta DOID:2394 / ovarian cancer [ cosmic, icgc ]
K137 R137 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
S140 F140 Biomuta DOID:4159 / skin cancer [ cosmic ]
S142 F142 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
T155 M155 Biomuta [ cosmic ] DOID:9256 / colorectal cancer [ cosmic, icgc ] DOID:1115 / sarcoma [ icgc, tcga ]
S191 Y191 Biomuta DOID:10534 / stomach cancer [ cosmic ]
T228 A228 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
S234 F234 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
K351 T351 Biomuta DOID:3571 / liver cancer [ cosmic, icgc ]
K351 N351 Biomuta DOID:1725 / peritoneum cancer [ cosmic ]
K398 R398 Biomuta DOID:10534 / stomach cancer [ cosmic ]
K637 R637 Biomuta DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ]
Y904 * Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S987 P987 Biomuta DOID:1324 / lung cancer [ cosmic ] DOID:2531 / hematologic cancer [ cosmic, icgc, cosmic ] DOID:1781 / thyroid cancer [ icgc ] DOID:4159 / skin cancer [ cosmic ] DOID:9256 / colorectal cancer [ cosmic ] DOID:10534 / stomach cancer [ cosmic ] DOID:1781 / thyroid gland cancer [ cosmic ]
T1008 I1008 Biomuta DOID:10534 / stomach cancer [ cosmic ]
S1039 L1039 Biomuta DOID:2394 / ovarian cancer [ cosmic ]
S1063 P1063 Biomuta DOID:2531 / hematologic cancer [ cosmic, icgc ]
S1069 N1069 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
S1070 R1070 Biomuta DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ]
S1070 N1070 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
K1386 M1386 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
S1843 R1843 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S1999 A1999 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ] DOID:4159 / skin cancer [ cosmic, icgc ] DOID:10534 / stomach cancer [ cosmic ]
S2014 A2014 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
T2050 M2050 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]