iPTMnet Report for Q92611 (EDEM1)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q92611 / EDEM1_HUMAN
Protein Name ER degradation-enhancing alpha-mannosidase-like protein 1
Gene Name Name: EDEM1
Synonyms:EDEM,KIAA0212;
Organism Homo sapiens (Human)

PRO ID PR:Q92611
DAG View
PRO Name ER degradation-enhancing alpha-mannosidase-like protein 1 (human)
Definition An ER degradation-enhancing alpha-mannosidase-like protein 1 that is encoded in the genome of human.
Short Label hEDEM1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q92611 (EDEM1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K116 Ubiquitination PhosphoSitePlus
K279 Ubiquitination PhosphoSitePlus
K334 Ubiquitination PhosphoSitePlus
N342 N-Glycosylation GlyGen 24190977
T498 Phosphorylation IEDB 32157095
S520 Phosphorylation PhosphoSitePlus
K528 Ubiquitination PhosphoSitePlus
C529 Methylation IEDB 31844290
C555 Methylation IEDB 31844290
K570 Ubiquitination PhosphoSitePlus
Y575 Phosphorylation PhosphoSitePlus
K596 Ubiquitination PhosphoSitePlus
K621 Ubiquitination PhosphoSitePlus
N624 N-Glycosylation GlyGen 24190977
N628 N-Glycosylation GlyGen 24190977
N630 N-Glycosylation GlyGen 24190977
K643 Ubiquitination PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
C529 R529 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
K570 T570 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]