Protein Information

Cytoscape View


UniProt AC / UniProt ID Q92598 / HS105_HUMAN
Protein Name Heat shock protein 105 kDa
Gene Name Name: HSPH1
Synonyms:HSP105,HSP110,KIAA0201;
Organism Homo sapiens (Human)

PRO ID PR:Q92598
DAG View
PRO Name heat shock protein 105 kDa (human)
Definition A heat shock protein 105 kDa that is encoded in the genome of human.
Short Label hHSPH1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q92598 (HSPH1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S2 Acetylation UniProt 22223895
S2 Phosphorylation PhosphoSitePlus
T25 Phosphorylation PhosphoSitePlus
S31 Phosphorylation PhosphoSitePlus
R33 Methylation PhosphoSitePlus
S43 Phosphorylation PhosphoSitePlus
K44 Ubiquitination PhosphoSitePlus
K53 Ubiquitination PhosphoSitePlus
K68 Acetylation PhosphoSitePlus
K68 Methylation PhosphoSitePlus
K68 Ubiquitination PhosphoSitePlus
K82 Ubiquitination PhosphoSitePlus
K84 Ubiquitination PhosphoSitePlus
Y89 Phosphorylation PhosphoSitePlus
K95 Ubiquitination PhosphoSitePlus
K102 Ubiquitination PhosphoSitePlus
K126 Ubiquitination PhosphoSitePlus
S132 Phosphorylation PhosphoSitePlus
T138 Phosphorylation PhosphoSitePlus
T149 Phosphorylation PhosphoSitePlus
K185 Ubiquitination PhosphoSitePlus
K194 Acetylation PhosphoSitePlus
K194 Ubiquitination PhosphoSitePlus
K221 Acetylation PhosphoSitePlus
K221 Ubiquitination PhosphoSitePlus
K234 Acetylation PhosphoSitePlus
K234 Ubiquitination PhosphoSitePlus
K239 Ubiquitination PhosphoSitePlus
K249 Acetylation PhosphoSitePlus
K249 Ubiquitination PhosphoSitePlus
R265 Methylation PhosphoSitePlus
K272 Acetylation PhosphoSitePlus
K272 Ubiquitination PhosphoSitePlus
K274 Acetylation PhosphoSitePlus
K275 Ubiquitination PhosphoSitePlus
K295 Ubiquitination PhosphoSitePlus
S298 O-Glycosylation GlyGen 23301498, 32119511, 21740066, ...29351928
K300 Ubiquitination PhosphoSitePlus
S304 O-Glycosylation GlyGen 23301498, 32119511, 21740066, ...29351928
S304 Phosphorylation PhosphoSitePlus
Y322 Phosphorylation PhosphoSitePlus
K351 Ubiquitination PhosphoSitePlus
K356 Ubiquitination PhosphoSitePlus
K360 Acetylation PhosphoSitePlus
K360 Ubiquitination PhosphoSitePlus
T365 Phosphorylation PhosphoSitePlus
S384 Phosphorylation phospho.ELM   PhosphoSitePlus 16964243
K388 Methylation PhosphoSitePlus
K388 Ubiquitination PhosphoSitePlus
S429 Phosphorylation PhosphoSitePlus
K430 Acetylation PhosphoSitePlus
K430 Ubiquitination PhosphoSitePlus
T433 Phosphorylation PhosphoSitePlus
Y446 Phosphorylation PhosphoSitePlus
K458 Ubiquitination PhosphoSitePlus
S468 Phosphorylation PhosphoSitePlus
K471 Ubiquitination PhosphoSitePlus
K475 Ubiquitination PhosphoSitePlus
T486 Phosphorylation PhosphoSitePlus
S493 Phosphorylation PhosphoSitePlus
T494 Phosphorylation PhosphoSitePlus
T503 Phosphorylation PhosphoSitePlus
S509 Phosphorylation RLIMS-P 12558502
S554 Phosphorylation PhosphoSitePlus
S557 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 21406692, 17287340, 20068231
T561 Phosphorylation PhosphoSitePlus   UniProt 24275569
S562 Phosphorylation PhosphoSitePlus
K588 Ubiquitination PhosphoSitePlus
K590 Ubiquitination PhosphoSitePlus
Y614 Phosphorylation PhosphoSitePlus
K626 Ubiquitination PhosphoSitePlus
K635 Ubiquitination PhosphoSitePlus
Y641 Phosphorylation PhosphoSitePlus
Y643 Phosphorylation PhosphoSitePlus
K648 Acetylation PhosphoSitePlus
K648 Ubiquitination PhosphoSitePlus
Y653 Phosphorylation PhosphoSitePlus
K655 Ubiquitination PhosphoSitePlus
T670 Phosphorylation PhosphoSitePlus
T672 Phosphorylation PhosphoSitePlus
Y677 Phosphorylation PhosphoSitePlus
Y688 Phosphorylation PhosphoSitePlus
K691 Ubiquitination PhosphoSitePlus
K697 Ubiquitination PhosphoSitePlus
T700 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
K703 Ubiquitination PhosphoSitePlus
K714 Ubiquitination PhosphoSitePlus
K749 Ubiquitination PhosphoSitePlus
K772 Ubiquitination PhosphoSitePlus
K790 Ubiquitination PhosphoSitePlus
K804 Ubiquitination PhosphoSitePlus
K806 Ubiquitination PhosphoSitePlus
S809 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 19369195, 21406692, 16083285, ...23186163, 17081983, 18669648, 17287340, 20068231
K811 Acetylation PhosphoSitePlus
K811 Ubiquitination PhosphoSitePlus
T815 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163, 16964243, ...20068231
K823 Ubiquitination PhosphoSitePlus
K824 Ubiquitination PhosphoSitePlus
S852 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S509 Phosphorylation P19784 (CSNK2A2) , P68400 (CSNK2A1) HPRD 12558502, 10772927
S554 Phosphorylation HPRD 20068231
S557 Phosphorylation HPRD 19413330, 15345747, 17287340, ...20068231
S562 Phosphorylation HPRD 19413330
T700 Phosphorylation HPRD 18669648, 20068231
S809 Phosphorylation HPRD 16083285, 17287340, 18212344, ...18767875, 19664995, 19651622, 18669648, 18707149, 20166139, 19415658, 20068231, 17924679
T815 Phosphorylation HPRD 18669648, 20068231


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
R33 L33 Biomuta DOID:1324 / lung cancer [ cosmic ]
K84 N84 Biomuta DOID:263 / kidney cancer [ cosmic, icgc, tcga ]
S132 R132 Biomuta DOID:1612 / breast cancer [ tcga ]
R265 H265 Biomuta DOID:363 / uterine cancer [ icgc, tcga ]
Y322 C322 Biomuta DOID:363 / uterine cancer [ tcga ]
K351 N351 Biomuta DOID:3571 / liver cancer [ tcga ]
K356 E356 Biomuta DOID:1324 / lung cancer [ cosmic ]
K360 N360 Biomuta DOID:1324 / lung cancer [ cosmic, tcga ]
S384 F384 Biomuta DOID:1909 / melanoma [ cosmic, tcga ]
S429 F429 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
T433 I433 Biomuta DOID:3571 / liver cancer [ tcga ]
T494 M494 Biomuta DOID:363 / uterine cancer [ icgc, tcga ]
S554 C554 Biomuta DOID:4362 / cervical cancer [ cosmic, icgc, tcga ]
K655 N655 Biomuta DOID:363 / uterine cancer [ tcga ]
T700 S700 Biomuta DOID:11934 / head and neck cancer [ tcga ]
K749 T749 Biomuta DOID:1324 / lung cancer [ tcga ]
K824 T824 Biomuta DOID:1324 / lung cancer [ cosmic ]
S852 F852 Biomuta DOID:1909 / melanoma [ icgc, tcga ] DOID:3070 / malignant glioma [ tcga ]
S852 Y852 Biomuta DOID:363 / uterine cancer [ cosmic, icgc, tcga ] DOID:9256 / colorectal cancer [ tcga ]