Protein Information

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UniProt AC / UniProt ID Q92597 / NDRG1_HUMAN
Protein Name Protein NDRG1
Gene Name Name: NDRG1
Synonyms:CAP43,DRG1,RTP;
Organism Homo sapiens (Human)

PRO ID PR:Q92597
DAG View
PRO Name protein NDRG1 (human)
Definition A protein NDRG1 that is encoded in the genome of human.
Short Label hNDRG1
Category organism-gene

Interactive Sequence View

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Q92597 (NDRG1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S2 Acetylation UniProt 19413330
S2 Phosphorylation PhosphoSitePlus   UniProt 23186163
K14 Sumoylation PhosphoSitePlus
K14 Ubiquitination PhosphoSitePlus
K19 Ubiquitination PhosphoSitePlus
T47 Phosphorylation RLIMS-P 23581296
K285 Ubiquitination PhosphoSitePlus
K300 Ubiquitination PhosphoSitePlus
K306 Ubiquitination PhosphoSitePlus
S319 Phosphorylation phospho.ELM   PhosphoSitePlus 15302935
S326 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648
T328 Phosphorylation O00141 (SGK1) neXtProt   phospho.ELM   PhosphoSitePlus   UniProt 23186163, 15461589, 18669648, ...24275569, 19690332
S330 Phosphorylation P17612 (PRKACA) , O00141 (SGK1) neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 23186163, 16964243, 20416281, ...17220478, 15461589, 15302935, 23287991, 33398037, 18669648, 31189711, 29679718, 19690332, 23634903
S332 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 24275569
S333 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 23186163, 16964243, 18669648, ...24275569, 20068231
T335 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S336 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 23186163, 18669648, 15302935
T340 Phosphorylation PhosphoSitePlus
S342 Phosphorylation P49841 (GSK3B) , P49840 (GSK3A) neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P 15461589
S344 Phosphorylation PhosphoSitePlus
T346 Phosphorylation O00141 (SGK1) neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 18787837, 28775290, 20416281, ...29679718, 15461589, 23287991, 31384305, 29898756, 30978004, 23581296, 29303911, 27894074, 31461270, 31189711
S347 Phosphorylation PhosphoSitePlus
T350 Phosphorylation PhosphoSitePlus
S352 Phosphorylation P49841 (GSK3B) , P49840 (GSK3A) neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P 15461589
S354 Phosphorylation PhosphoSitePlus
T356 Phosphorylation O00141 (SGK1) neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 18787837, 15461589
S357 Phosphorylation PhosphoSitePlus
T360 Phosphorylation PhosphoSitePlus
S362 Phosphorylation P49841 (GSK3B) , P49840 (GSK3A) neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P 15461589
S364 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163
T366 Phosphorylation P17612 (PRKACA) , O00141 (SGK1) neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 18787837, 23186163, 17220478, ...15461589, 18669648
S367 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
T375 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163
S378 Phosphorylation PhosphoSitePlus
S384 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S389 Phosphorylation PhosphoSitePlus
S393 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S319 Phosphorylation HPRD 15302935
S326 Phosphorylation HPRD 17322306, 19651622, 18669648, ...20166139
T328 Phosphorylation HPRD 17322306, 18491316, 19651622, ...18669648, 20166139, 20068231
S330 Phosphorylation P17612 (PRKACA) HPRD 19413330, 16964243, 17220478, ...19664994, 19651622, 18669648, 18767875, 20166139, 20068231
G331 Phosphorylation HPRD 17322306
S332 Phosphorylation HPRD 19413330, 17081983, 18452278, ...19651622, 18669648, 20166139
S333 Phosphorylation HPRD 19413330, 16964243, 18767875, ...19651622, 18669648, 20068231, 17081983
T335 Phosphorylation HPRD 19413330, 19651622, 18669648, ...17081983
S336 Phosphorylation HPRD 17322306, 19651622, 18669648
S362 Phosphorylation HPRD 19651622, 17081983, 20068231
S364 Phosphorylation HPRD 19413330, 18491316, 17081983, ...19651622, 18669648, 20068231
T366 Phosphorylation P17612 (PRKACA) HPRD 18491316, 17220478, 19651622, ...18669648, 20166139, 20068231
S367 Phosphorylation HPRD 18669648, 18491316, 17081983
T375 Phosphorylation HPRD 18669648, 17081983, 20068231
S378 Phosphorylation HPRD 17081983
S384 Phosphorylation HPRD 18669648


PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation Q92597 (NDRG1) T346 P04626 (ERBB2) unknown eFIP 31384305


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K306 N306 Biomuta DOID:363 / uterine cancer [ tcga ]
S336 C336 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc, tcga ]
T350 P350 Biomuta DOID:263 / kidney cancer [ tcga ]
S352 I352 Biomuta DOID:3963 / thyroid carcinoma [ cosmic ]
S362 R362 Biomuta DOID:363 / uterine cancer [ cosmic, icgc, tcga ]
S367 N367 Biomuta DOID:9256 / colorectal cancer [ icgc, tcga ] DOID:1909 / melanoma [ cosmic ]
S378 L378 Biomuta DOID:363 / uterine cancer [ tcga ]
S389 F389 Biomuta DOID:2531 / hematologic cancer [ icgc ]