iPTMnet Report Q92597 NDRG1

Protein Information

UniProt AC / UniProt ID	Q92597 / NDRG1_HUMAN
Protein Name	Protein NDRG1
Gene Name	Name: NDRG1 Synonyms:CAP43,DRG1,RTP;
Organism	Homo sapiens (Human)

PRO ID	PR:Q92597 DAG View
PRO Name	protein NDRG1 (human)
Definition	A protein NDRG1 that is encoded in the genome of human.
Short Label	hNDRG1
Category	organism-gene

Interactive Sequence View

	Select/align proteoforms across species

Q92597 (NDRG1) as Substrate

Expanded View

Search:

Site Select all By amino acid All Serine All Threonine By position S2 K14 K19 T47 K285 K300 K306 S319 S326 T328 S330 S332 S333 T335 S336 T340 S342 S344 T346 S347 T350 S352 S354 T356 S357 T360 S362 S364 T366 S367 T375 S378 S384 S389 S393 C394	PTM Type Select all Acetylation Methylation O-Glycosylation Phosphorylation Sumoylation Ubiquitination	PTM Enzyme	Score Select all 0 1 2 3 4	Source Select all GlyGen IEDB PhosphoSitePlus RLIMS-P Signor UniProt neXtProt phospho.ELM	PMID
S2	Acetylation		score1	UniProt	19413330
S2	Phosphorylation		score2	PhosphoSitePlus UniProt	23186163
K14	Sumoylation		score1	PhosphoSitePlus
K14	Ubiquitination		score1	PhosphoSitePlus
K19	Ubiquitination		score1	PhosphoSitePlus
T47	Phosphorylation		score0	RLIMS-P	23581296
K285	Ubiquitination		score1	PhosphoSitePlus
K300	Ubiquitination		score1	PhosphoSitePlus
K306	Ubiquitination		score1	PhosphoSitePlus
S319	Phosphorylation		score2	phospho.ELM PhosphoSitePlus	15302935
S326	Phosphorylation		score2	phospho.ELM PhosphoSitePlus UniProt	18669648
T328	Phosphorylation	O00141 (SGK1)	score4	neXtProt phospho.ELM PhosphoSitePlus UniProt	23186163, 15461589, 18669648, ...24275569, 19690332
S330	Phosphorylation	O00141 (SGK1) , P17612 (PRKACA)	score4	neXtProt phospho.ELM PhosphoSitePlus RLIMS-P Signor UniProt	23186163, 16964243, 20416281, ...17220478, 15461589, 15302935, 23287991, 33398037, 18669648, 31189711, 29679718, 19690332, 23634903
S332	Phosphorylation		score2	phospho.ELM PhosphoSitePlus UniProt	18669648, 24275569
S333	Phosphorylation		score2	phospho.ELM PhosphoSitePlus UniProt	23186163, 16964243, 18669648, ...24275569, 20068231
T335	Phosphorylation		score2	phospho.ELM PhosphoSitePlus	18669648
S336	Phosphorylation		score2	phospho.ELM PhosphoSitePlus UniProt	23186163, 18669648, 15302935
T340	Phosphorylation		score1	PhosphoSitePlus
S342	Phosphorylation	P49841 (GSK3B) , P49840 (GSK3A)	score3	neXtProt phospho.ELM PhosphoSitePlus RLIMS-P	15461589
S344	Phosphorylation		score1	PhosphoSitePlus
T346	Phosphorylation	O00141 (SGK1)	score4	neXtProt phospho.ELM PhosphoSitePlus RLIMS-P Signor UniProt	18787837, 28775290, 20416281, ...29679718, 15461589, 23287991, 29898756, 30978004, 23581296, 29303911, 27894074, 31461270, 31189711
S347	O-Glycosylation		score1	GlyGen	23301498, 30379171, 34019948, ...26853435, 32870666
S347	Phosphorylation		score1	PhosphoSitePlus
T350	Phosphorylation		score1	PhosphoSitePlus
S352	Phosphorylation	P49841 (GSK3B) , P49840 (GSK3A)	score3	neXtProt phospho.ELM PhosphoSitePlus RLIMS-P	15461589
S354	Phosphorylation		score1	PhosphoSitePlus
T356	Phosphorylation	O00141 (SGK1)	score4	neXtProt phospho.ELM PhosphoSitePlus RLIMS-P Signor UniProt	18787837, 15461589
S357	O-Glycosylation		score1	GlyGen	23301498, 30379171, 34019948, ...26853435, 32870666
S357	Phosphorylation		score1	PhosphoSitePlus
T360	Phosphorylation		score1	PhosphoSitePlus
S362	Phosphorylation	P49841 (GSK3B) , P49840 (GSK3A)	score3	neXtProt phospho.ELM PhosphoSitePlus RLIMS-P	15461589
S364	Phosphorylation		score2	phospho.ELM PhosphoSitePlus UniProt	18669648, 23186163
T366	Phosphorylation	P17612 (PRKACA) , O00141 (SGK1)	score4	neXtProt phospho.ELM PhosphoSitePlus RLIMS-P Signor UniProt	18787837, 23186163, 17220478, ...15461589, 18669648
S367	Phosphorylation		score2	phospho.ELM PhosphoSitePlus	18669648
T375	Phosphorylation		score2	phospho.ELM PhosphoSitePlus UniProt	18669648, 23186163
S378	Phosphorylation		score1	PhosphoSitePlus
S384	Phosphorylation		score2	phospho.ELM PhosphoSitePlus	18669648
S389	Phosphorylation		score1	PhosphoSitePlus
S393	Phosphorylation		score1	PhosphoSitePlus
C394	Methylation		score1	IEDB	31844290

Search:

Site Select all By amino acid All Serine All Threonine By position S319 S326 T328 S330 G331 S332 S333 T335 S336 S362 S364 T366 S367 T375 S378 S384	PTM Type Select all Phosphorylation	PTM Enzyme	Score Select all 0 2	Source Select all HPRD	PMID
S319	Phosphorylation		score0	HPRD	15302935
S326	Phosphorylation		score0	HPRD	17322306, 19651622, 18669648, ...20166139
T328	Phosphorylation		score0	HPRD	17322306, 18491316, 19651622, ...18669648, 20166139, 20068231
S330	Phosphorylation	P17612 (PRKACA)	score2	HPRD	19413330, 16964243, 17220478, ...19664994, 19651622, 18669648, 18767875, 20166139, 20068231
G331	Phosphorylation		score0	HPRD	17322306
S332	Phosphorylation		score0	HPRD	19413330, 17081983, 18452278, ...19651622, 18669648, 20166139
S333	Phosphorylation		score0	HPRD	19413330, 16964243, 18767875, ...19651622, 18669648, 20068231, 17081983
T335	Phosphorylation		score0	HPRD	19413330, 19651622, 18669648, ...17081983
S336	Phosphorylation		score0	HPRD	17322306, 19651622, 18669648
S362	Phosphorylation		score0	HPRD	19651622, 17081983, 20068231
S364	Phosphorylation		score0	HPRD	19413330, 18491316, 17081983, ...19651622, 18669648, 20068231
T366	Phosphorylation	P17612 (PRKACA)	score2	HPRD	18491316, 17220478, 19651622, ...18669648, 20166139, 20068231
S367	Phosphorylation		score0	HPRD	18669648, 18491316, 17081983
T375	Phosphorylation		score0	HPRD	18669648, 17081983, 20068231
S378	Phosphorylation		score0	HPRD	17081983
S384	Phosphorylation		score0	HPRD	18669648

PTM-dependent PPI

Search:

	PTM type Select all Phosphorylation	Substrate Select all Q92597 (NDRG1)	Site Select all By amino acid All Threonine By position T346	Interactant Select all P04626 (ERBB2)	Association type Select all unknown	Source Select all eFIP	PMID
	Phosphorylation	Q92597 (NDRG1)	T346	P04626 (ERBB2)	unknown	eFIP	31384305

PTM sites affected in variants

Search:

Site Select all By amino acid All Serine All Threonine By position K306 S336 T350 S352 S362 S367 T375 S378 S389	Variant Select all C336 F389 I352 L378 N306 N367 P350 P375 R362	Source Select all Biomuta	Disease [Sample source] Select all DOID:11054 / urinary bladder cancer [ icgc ] DOID:1612 / breast cancer [ cosmic ] DOID:1781 / thyroid gland cancer [ cosmic ] DOID:2531 / hematologic cancer [ cosmic ] DOID:263 / kidney cancer [ cosmic, icgc ] DOID:363 / uterine cancer [ cosmic, icgc ] DOID:9256 / colorectal cancer [ cosmic, icgc ]
K306	N306	Biomuta	DOID:363 / uterine cancer [ cosmic, icgc ]
S336	C336	Biomuta	DOID:11054 / urinary bladder cancer [ icgc ]
T350	P350	Biomuta	DOID:263 / kidney cancer [ cosmic, icgc ]
S352	I352	Biomuta	DOID:1781 / thyroid gland cancer [ cosmic ]
S362	R362	Biomuta	DOID:363 / uterine cancer [ cosmic, icgc ]
S367	N367	Biomuta	DOID:9256 / colorectal cancer [ cosmic, icgc ]
T375	P375	Biomuta	DOID:1612 / breast cancer [ cosmic ]
S378	L378	Biomuta	DOID:363 / uterine cancer [ cosmic, icgc ]
S389	F389	Biomuta	DOID:2531 / hematologic cancer [ cosmic ]

PTM Type		Select All, None
Acetylation	N-Glycosylation	O-Glycosylation
C-Glycosylation	S-Glycosylation	Methylation
Myristoylation	Phosphorylation	Sumoylation
Ubiquitination	S-Nitrosylation

Select organisms		Select All, None
Human	Mouse	Rat
Cow	Chicken	Zebrafish
Fruit fly	C. elegans	Baker's yeast
Fission yeast	A. thaliana	Maize
M. truncatula	Rice (japonica)	Rice (indica)

Or input other organisms

iPTMnet Report for Q92597 (NDRG1)

Protein Information

Interactive Sequence View

Q92597 (NDRG1) as Substrate

PTM-dependent PPI

PTM sites affected in variants