iPTMnet Report for Q92574 (TSC1)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q92574 / TSC1_HUMAN
Protein Name Hamartin
Gene Name Name: TSC1
Synonyms:KIAA0243;
Organism Homo sapiens (Human)

PRO ID PR:Q92574
DAG View
PRO Name hamartin (human)
Definition A hamartin that is encoded in the genome of human.
Short Label hTSC1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q92574 (TSC1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
Y79 Phosphorylation PhosphoSitePlus
S91 Phosphorylation PhosphoSitePlus
S102 Phosphorylation PhosphoSitePlus
S108 Phosphorylation PhosphoSitePlus
S115 Phosphorylation PhosphoSitePlus
T138 Phosphorylation IEDB 35494241
S205 Phosphorylation PhosphoSitePlus
K221 Ubiquitination PhosphoSitePlus
K238 Ubiquitination PhosphoSitePlus
T267 Phosphorylation PhosphoSitePlus
S270 Phosphorylation PhosphoSitePlus
Y271 Phosphorylation PhosphoSitePlus
Y275 Phosphorylation PhosphoSitePlus
S282 Phosphorylation PhosphoSitePlus
S295 Phosphorylation PhosphoSitePlus
Y297 Phosphorylation PhosphoSitePlus
S303 Phosphorylation PhosphoSitePlus
Y304 Phosphorylation PhosphoSitePlus
T310 Phosphorylation PhosphoSitePlus
Y312 Phosphorylation PhosphoSitePlus
T357 Phosphorylation PhosphoSitePlus
T360 Phosphorylation PhosphoSitePlus
T390 Phosphorylation PhosphoSitePlus
T393 Phosphorylation PhosphoSitePlus
S394 Phosphorylation PhosphoSitePlus
Y406 Phosphorylation PhosphoSitePlus
T417 Phosphorylation neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor 20006582, 14551205
T417 Phosphorylation P06493 (CDK1) phospho.ELM   PhosphoSitePlus   Signor 14551205
S427 Phosphorylation PhosphoSitePlus
S468 Phosphorylation PhosphoSitePlus
S472 Phosphorylation PhosphoSitePlus
K477 Ubiquitination PhosphoSitePlus
S483 Phosphorylation PhosphoSitePlus
S487 Phosphorylation neXtProt   PhosphoSitePlus   Signor   UniProt 17693255, 19188143, 23186163
S487 Phosphorylation O14920 (IKBKB) neXtProt   PhosphoSitePlus   Signor 17693255, 19188143
T490 Phosphorylation PhosphoSitePlus
S505 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 23186163, 15963462, 18669648, ...18088087, 19690332
Y508 Phosphorylation PhosphoSitePlus
S511 Phosphorylation neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 22848663, 17693255, 18669648, ...19188143, 24135021
S511 Phosphorylation O14920 (IKBKB) neXtProt   PhosphoSitePlus   Signor 17693255, 19188143, 24135021
S515 Phosphorylation PhosphoSitePlus
S521 Phosphorylation PhosphoSitePlus   UniProt 23186163
T547 Phosphorylation PhosphoSitePlus
S579 Phosphorylation PhosphoSitePlus
S584 Phosphorylation neXtProt   phospho.ELM   PhosphoSitePlus   Signor 14551205
S584 Phosphorylation P06493 (CDK1) phospho.ELM   PhosphoSitePlus   Signor 14551205
S598 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648
Y604 Phosphorylation PhosphoSitePlus
K662 Ubiquitination PhosphoSitePlus
K672 Ubiquitination PhosphoSitePlus
S673 Phosphorylation PhosphoSitePlus
S682 Phosphorylation PhosphoSitePlus
K725 Ubiquitination PhosphoSitePlus
K737 Ubiquitination PhosphoSitePlus
K751 Acetylation PhosphoSitePlus
K756 Ubiquitination PhosphoSitePlus
K774 Ubiquitination PhosphoSitePlus
S871 Phosphorylation PhosphoSitePlus
T873 Phosphorylation PhosphoSitePlus
T874 Phosphorylation PhosphoSitePlus
K934 Ubiquitination PhosphoSitePlus
T1020 Phosphorylation PhosphoSitePlus
S1024 Phosphorylation PhosphoSitePlus
S1025 Phosphorylation PhosphoSitePlus
S1029 Phosphorylation PhosphoSitePlus
S1030 Phosphorylation PhosphoSitePlus
R1033 Methylation PhosphoSitePlus
S1046 Phosphorylation PhosphoSitePlus
T1047 Phosphorylation neXtProt   phospho.ELM   PhosphoSitePlus   Signor 14551205
T1047 Phosphorylation P06493 (CDK1) phospho.ELM   PhosphoSitePlus   Signor 14551205
T1077 O-Glycosylation GlyGen 32938750
S1080 Phosphorylation PhosphoSitePlus
S1100 Phosphorylation PhosphoSitePlus   UniProt 24275569
S1102 Phosphorylation phospho.ELM   PhosphoSitePlus 17525332
S1114 Phosphorylation PhosphoSitePlus
S1116 Phosphorylation PhosphoSitePlus
S1141 Phosphorylation PhosphoSitePlus
T1144 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
T417 Phosphorylation HPRD 14551205
T417 Phosphorylation P06493 (CDK1) HPRD 14551205
S505 Phosphorylation HPRD 19413330, 18212344, 15963462, ...19664994, 20058876, 18669648
S511 Phosphorylation HPRD 18669648
S584 Phosphorylation HPRD 14551205
S584 Phosphorylation P06493 (CDK1) HPRD 14551205
S598 Phosphorylation HPRD 18669648
T1047 Phosphorylation HPRD 14551205
T1047 Phosphorylation P06493 (CDK1) HPRD 14551205
S1102 Phosphorylation HPRD 19413330, 17525332


PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation Q92574 (TSC1) T417 P34932 (HSPA4) unknown eFIP 20006582


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
Y79 C79 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
Y79 H79 Biomuta DOID:11054 / urinary bladder cancer [ cosmic ]
S91 L91 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S102 F102 Biomuta DOID:1319 / brain cancer [ icgc ]
S108 P108 Biomuta DOID:4159 / skin cancer [ cosmic ]
S108 F108 Biomuta DOID:4159 / skin cancer [ cosmic ]
S115 F115 Biomuta DOID:1612 / breast cancer [ cosmic ] DOID:11054 / urinary bladder cancer [ cosmic ]
S205 Y205 Biomuta DOID:263 / kidney cancer [ cosmic ]
S205 F205 Biomuta [ cosmic ]
K238 * Biomuta DOID:1612 / breast cancer [ cosmic ]
S270 * Biomuta DOID:3571 / liver cancer [ cosmic ]
S270 P270 Biomuta DOID:363 / uterine cancer [ cosmic ]
Y275 F275 Biomuta [ cosmic ]
S282 * Biomuta DOID:1793 / pancreatic cancer [ cosmic ] DOID:10534 / stomach cancer [ cosmic ] DOID:11054 / urinary bladder cancer [ cosmic ]
T360 N360 Biomuta [ cosmic ]
S394 Y394 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S468 F468 Biomuta DOID:4159 / skin cancer [ cosmic ] DOID:1324 / lung cancer [ cosmic ]
S472 N472 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
K477 E477 Biomuta DOID:1612 / breast cancer [ cosmic ]
K477 N477 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
K477 * Biomuta DOID:11054 / urinary bladder cancer [ cosmic ]
S487 C487 Biomuta DOID:1781 / thyroid gland cancer [ cosmic ]
S505 P505 Biomuta DOID:11054 / urinary bladder cancer [ cosmic ]
S511 R511 Biomuta DOID:1612 / breast cancer [ cosmic ]
T547 A547 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
S598 C598 Biomuta DOID:1319 / brain cancer [ cosmic ]
K662 * Biomuta DOID:1324 / lung cancer [ cosmic ]
S673 F673 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]
S871 * Biomuta DOID:363 / uterine cancer [ cosmic ] DOID:11054 / urinary bladder cancer [ cosmic ]
S1029 N1029 Biomuta DOID:1324 / lung cancer [ cosmic ]
R1033 S1033 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
T1047 I1047 Biomuta DOID:1324 / lung cancer [ cosmic ]
S1080 * Biomuta DOID:5041 / esophageal cancer [ cosmic ]
S1100 N1100 Biomuta DOID:9256 / colorectal cancer [ cosmic ]