iPTMnet Report for Q92572 (AP3S1)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q92572 / AP3S1_HUMAN
Protein Name AP-3 complex subunit sigma-1
Gene Name Name: AP3S1
Synonyms:CLAPS3;
Organism Homo sapiens (Human)

PRO ID PR:Q92572
DAG View
PRO Name AP-3 complex subunit sigma-1 (human)
Definition An AP-3 complex subunit sigma-1 that is encoded in the genome of human.
Short Label hAP3S1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q92572 (AP3S1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K13 Ubiquitination PhosphoSitePlus
K18 Ubiquitination PhosphoSitePlus
K41 Ubiquitination PhosphoSitePlus
K149 Ubiquitination PhosphoSitePlus
S150 Phosphorylation HPRD   PhosphoSitePlus 20068231
K166 Acetylation PhosphoSitePlus
K166 Ubiquitination PhosphoSitePlus
S183 Phosphorylation PhosphoSitePlus
K185 Ubiquitination PhosphoSitePlus
S191 Phosphorylation PhosphoSitePlus   UniProt 23186163
K193 Acetylation PhosphoSitePlus
K193 Methylation PhosphoSitePlus
K193 Ubiquitination PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K13 E13 Biomuta DOID:10534 / stomach cancer [ cosmic ]
K13 N13 Biomuta DOID:1324 / lung cancer [ cosmic ]
S183 N183 Biomuta DOID:4606 / bile duct cancer [ cosmic ] DOID:3565 / meningioma [ cosmic ] DOID:1324 / lung cancer [ cosmic, icgc ] DOID:2531 / hematologic cancer [ cosmic, icgc ] DOID:1781 / thyroid cancer [ icgc ] DOID:1781 / thyroid gland cancer [ cosmic ]
K185 * Biomuta DOID:4159 / skin cancer [ cosmic ]
S191 Y191 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
S191 P191 Biomuta DOID:3571 / liver cancer [ cosmic, icgc ]