Protein Information

Cytoscape View


UniProt AC / UniProt ID Q92569 / P55G_HUMAN
Protein Name Phosphatidylinositol 3-kinase regulatory subunit gamma
Gene Name Name: PIK3R3
Organism Homo sapiens (Human)

PRO ID PR:Q92569
DAG View
PRO Name phosphatidylinositol 3-kinase regulatory subunit gamma (human)
Definition A phosphatidylinositol 3-kinase regulatory subunit gamma that is encoded in the genome of human.
Short Label hPIK3R3
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q92569 (PIK3R3) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
Ubiquitination PRO
K78 Ubiquitination PhosphoSitePlus
K106 Acetylation PhosphoSitePlus
K111 Ubiquitination PhosphoSitePlus
K114 Acetylation PhosphoSitePlus
K114 Ubiquitination PhosphoSitePlus
K155 Ubiquitination PhosphoSitePlus
Y163 Phosphorylation PhosphoSitePlus
K170 Ubiquitination PhosphoSitePlus
K180 Ubiquitination PhosphoSitePlus
Y184 Phosphorylation PhosphoSitePlus
S186 Phosphorylation PhosphoSitePlus
Y188 Phosphorylation PhosphoSitePlus
K191 Ubiquitination PhosphoSitePlus
Y195 Phosphorylation PhosphoSitePlus
Y199 Phosphorylation PhosphoSitePlus
Y202 Phosphorylation PhosphoSitePlus
T203 Phosphorylation PhosphoSitePlus
T222 Phosphorylation PhosphoSitePlus
K224 Ubiquitination PhosphoSitePlus
K238 Ubiquitination PhosphoSitePlus
Y260 Phosphorylation PhosphoSitePlus
S273 Phosphorylation PhosphoSitePlus
K274 Ubiquitination PhosphoSitePlus
K294 Ubiquitination PhosphoSitePlus
K299 Ubiquitination PhosphoSitePlus
K319 Ubiquitination PhosphoSitePlus
Y341 Phosphorylation P06213 (INSR) phospho.ELM   PhosphoSitePlus   Signor 7542745
Y373 Phosphorylation PhosphoSitePlus
K375 Ubiquitination PhosphoSitePlus
K388 Ubiquitination PhosphoSitePlus
Y407 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
Y341 Phosphorylation HPRD 7542745


Proteoforms

PRO ID (Short Label) Sites PTM Enzyme Source PMID
PR:000048772 (hPIK3R3/UbiqLys+) ub PRO


PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation P00533 (EGFR) Y1016 Q92569 (PIK3R3) unknown eFIP 16273093
Phosphorylation P04626 (ERBB2) Y1196 Q92569 (PIK3R3) unknown eFIP 16273093
Phosphorylation P21860 (ERBB3) Y1224 Q92569 (PIK3R3) unknown eFIP 16273093
Phosphorylation Q08345 (DDR1) Y881 Q92569 (PIK3R3) unknown eFIP 22057045
Phosphorylation Q8IZP0 (ABI1) Y421 Q92569 (PIK3R3) unknown eFIP 20598684


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K114 Q114 Biomuta DOID:363 / uterine cancer [ tcga ]
Y184 F184 Biomuta DOID:1324 / lung cancer [ cosmic ]
T203 A203 Biomuta DOID:3571 / liver cancer [ icgc, tcga ] DOID:0070003 / blastoma [ cosmic ]
T222 I222 Biomuta DOID:5041 / esophageal cancer [ icgc ]
K224 T224 Biomuta DOID:363 / uterine cancer [ tcga ]
S273 T273 Biomuta DOID:363 / uterine cancer [ cosmic, icgc, tcga ]
K299 E299 Biomuta DOID:363 / uterine cancer [ tcga ]
Y341 F341 Biomuta DOID:10283 / prostate cancer [ cosmic ]