iPTMnet Report for Q92560 (BAP1)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q92560 / BAP1_HUMAN
Protein Name Ubiquitin carboxyl-terminal hydrolase BAP1
Gene Name Name: BAP1
Synonyms:KIAA0272;ORFNames:hucep-6;
Organism Homo sapiens (Human)

PRO ID PR:Q92560
DAG View
PRO Name ubiquitin carboxyl-terminal hydrolase BAP1 (human)
Definition A ubiquitin carboxyl-terminal hydrolase BAP1 that is encoded in the genome of human.
Short Label hBAP1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q92560 (BAP1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K120 Ubiquitination PhosphoSitePlus
S123 Phosphorylation PhosphoSitePlus
K127 Ubiquitination PhosphoSitePlus
K139 Ubiquitination PhosphoSitePlus
K155 Acetylation PhosphoSitePlus
K155 Ubiquitination PhosphoSitePlus
Y223 Phosphorylation PhosphoSitePlus
Y241 Phosphorylation PhosphoSitePlus
T273 Phosphorylation PhosphoSitePlus
K275 Ubiquitination PhosphoSitePlus
S276 Phosphorylation PhosphoSitePlus
S287 Phosphorylation PhosphoSitePlus
S289 Phosphorylation PhosphoSitePlus
S292 Phosphorylation HPRD   PhosphoSitePlus   RLIMS-P   UniProt 19664994, 35905855, 23186163
S325 Phosphorylation PhosphoSitePlus
S327 Phosphorylation HPRD   PhosphoSitePlus 19413330
S369 Phosphorylation HPRD   PhosphoSitePlus   UniProt 23186163, 18452278
S384 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 18669648, 17081983
Y394 Phosphorylation HPRD   PhosphoSitePlus 17081983
S395 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 18669648, 18452278, 18220336
Y401 Phosphorylation PhosphoSitePlus
S460 Phosphorylation PhosphoSitePlus
S464 Phosphorylation HPRD   PhosphoSitePlus 20068231
S485 Phosphorylation PhosphoSitePlus
T487 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 15302935
S489 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 15302935
T493 Phosphorylation PhosphoSitePlus   UniProt 25451922
S505 Phosphorylation PhosphoSitePlus
S509 Phosphorylation PhosphoSitePlus
S513 Phosphorylation PhosphoSitePlus
T517 Phosphorylation PhosphoSitePlus
S520 Phosphorylation PhosphoSitePlus
S521 Phosphorylation HPRD   PhosphoSitePlus   UniProt 19651622, 23186163
T524 Phosphorylation PhosphoSitePlus
S525 Phosphorylation PhosphoSitePlus
S537 Phosphorylation PhosphoSitePlus   UniProt 23186163
S571 Phosphorylation PhosphoSitePlus
S582 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 19413330, 18669648
S583 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 17525332, 18077418
S585 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163
S592 Phosphorylation HPRD   IntAct   phospho.ELM   PhosphoSitePlus   RLIMS-P 17525332, 24211834, 18077418
S595 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 18669648
S596 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 18077418, 18669648
S597 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 19413330, 17525332, 23186163, ...18077418, 18669648
S609 Phosphorylation PhosphoSitePlus
K630 Ubiquitination PhosphoSitePlus
K656 Methylation PhosphoSitePlus
K658 Methylation PhosphoSitePlus
K659 Methylation PhosphoSitePlus
C676 Methylation IEDB 31844290
S705 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K120 * Biomuta DOID:3571 / liver cancer [ cosmic ] DOID:263 / kidney cancer [ cosmic ]
K120 N120 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S123 T123 Biomuta DOID:5041 / esophageal cancer [ cosmic ]
K127 E127 Biomuta DOID:263 / kidney cancer [ cosmic ]
Y223 F223 Biomuta DOID:1324 / lung cancer [ cosmic ]
Y223 * Biomuta DOID:2174 / ocular cancer [ tcga ] DOID:263 / kidney cancer [ cosmic ]
Y241 * Biomuta DOID:2174 / ocular cancer [ cosmic ]
T273 N273 Biomuta DOID:3571 / liver cancer [ cosmic ]
S287 * Biomuta DOID:5158 / pleural cancer [ cosmic ] DOID:263 / kidney cancer [ cosmic ]
S292 P292 Biomuta DOID:10283 / prostate cancer [ cosmic ]
S325 F325 Biomuta DOID:1324 / lung cancer [ cosmic ]
S327 I327 Biomuta DOID:363 / uterine cancer [ icgc ]
Y394 * Biomuta DOID:5158 / pleural cancer [ cosmic ]
S395 * Biomuta DOID:8618 / oral cavity cancer [ cosmic ] DOID:1612 / breast cancer [ cosmic ] DOID:2174 / ocular cancer [ cosmic ]
Y401 C401 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
S460 * Biomuta DOID:1612 / breast cancer [ cosmic ] DOID:1324 / lung cancer [ cosmic ] DOID:4362 / cervical cancer [ cosmic, tcga ] DOID:5158 / pleural cancer [ cosmic ] DOID:2174 / ocular cancer [ cosmic ] DOID:263 / kidney cancer [ cosmic ] DOID:8618 / oral cavity cancer [ cosmic ] DOID:11054 / urinary bladder cancer [ cosmic ]
S464 A464 Biomuta DOID:4159 / skin cancer [ cosmic ]
T487 S487 Biomuta DOID:2394 / ovarian cancer [ cosmic, icgc ]
S509 * Biomuta DOID:1793 / pancreatic cancer [ cosmic ]
S513 * Biomuta DOID:11615 / penile cancer [ cosmic ] DOID:3277 / thymus cancer [ cosmic ] DOID:5158 / pleural cancer [ cosmic ] DOID:263 / kidney cancer [ cosmic ]
T517 M517 Biomuta DOID:184 / bone cancer [ cosmic ] DOID:9256 / colorectal cancer [ cosmic ]
S520 P520 Biomuta DOID:263 / kidney cancer [ cosmic ]
S525 C525 Biomuta DOID:1612 / breast cancer [ cosmic ]
S583 L583 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
S596 G596 Biomuta [ cosmic ] DOID:3565 / meningioma [ cosmic ]
S609 G609 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
K656 N656 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc, tcga ]
K658 * Biomuta DOID:5158 / pleural cancer [ cosmic ]