iPTMnet Report for Q92547 (TOPBP1)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q92547 / TOPB1_HUMAN
Protein Name DNA topoisomerase 2-binding protein 1
Gene Name Name: TOPBP1
Synonyms:KIAA0259;
Organism Homo sapiens (Human)

PRO ID PR:Q92547
DAG View
PRO Name DNA topoisomerase 2-binding protein 1 (human)
Definition A DNA topoisomerase 2-binding protein 1 that is encoded in the genome of human.
Short Label hTOPBP1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q92547 (TOPBP1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K6 Ubiquitination PhosphoSitePlus
K15 Ubiquitination PhosphoSitePlus
K21 Ubiquitination PhosphoSitePlus
K31 Ubiquitination PhosphoSitePlus
K72 Ubiquitination PhosphoSitePlus
S142 Phosphorylation HPRD   PhosphoSitePlus 20068231
T144 Phosphorylation HPRD 20068231
S153 Phosphorylation PhosphoSitePlus
K155 Ubiquitination PhosphoSitePlus
K163 Ubiquitination PhosphoSitePlus
K164 Ubiquitination PhosphoSitePlus
K178 Ubiquitination PhosphoSitePlus
T185 Phosphorylation PhosphoSitePlus
Y187 Phosphorylation PhosphoSitePlus
T188 Phosphorylation PhosphoSitePlus
K224 Ubiquitination PhosphoSitePlus
K234 Ubiquitination PhosphoSitePlus
K247 Ubiquitination PhosphoSitePlus
K283 Ubiquitination PhosphoSitePlus
K291 Ubiquitination PhosphoSitePlus
T298 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 17525332, 23186163
T300 Phosphorylation PhosphoSitePlus
S301 O-Glycosylation GlyGen 30620550
S301 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 17525332
S350 Phosphorylation HPRD   PhosphoSitePlus 20068231
S370 Phosphorylation PhosphoSitePlus
K414 Ubiquitination PhosphoSitePlus
S492 Phosphorylation Q13315 (ATM) HPRD   neXtProt   phospho.ELM   PhosphoSitePlus 17525332, 11756551, 18077418
Y494 Phosphorylation PhosphoSitePlus
S498 Phosphorylation PhosphoSitePlus
S499 Phosphorylation PhosphoSitePlus
C540 Methylation IEDB 31844290
S554 Phosphorylation Q13315 (ATM) HPRD   neXtProt   PhosphoSitePlus 11756551
K581 Acetylation PhosphoSitePlus
S587 Phosphorylation PhosphoSitePlus
T618 Phosphorylation PhosphoSitePlus
S741 Phosphorylation PhosphoSitePlus
T742 Phosphorylation PhosphoSitePlus
K743 Ubiquitination PhosphoSitePlus
S747 Phosphorylation PhosphoSitePlus
T776 Phosphorylation PhosphoSitePlus
T779 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163
K789 Ubiquitination PhosphoSitePlus
S805 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 16964243, 19007248
S817 Phosphorylation PhosphoSitePlus
T822 Phosphorylation PhosphoSitePlus
S836 Phosphorylation PhosphoSitePlus
K840 Ubiquitination PhosphoSitePlus
T848 Phosphorylation P24941 (CDK2) HPRD   phospho.ELM   PhosphoSitePlus   UniProt 18669648, 18847512
S853 Phosphorylation Q13315 (ATM) HPRD   neXtProt   PhosphoSitePlus 11756551
K856 Ubiquitination PhosphoSitePlus
S860 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163
T861 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163, 20068231
S864 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163, 20068231
S878 Phosphorylation PhosphoSitePlus
S879 Phosphorylation PhosphoSitePlus
S886 Phosphorylation HPRD   PhosphoSitePlus   UniProt 20068231
S888 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 23186163, 16964243, 19007248, ...19664995, 17322306, 18669648, 19690332, 20068231
S998 Phosphorylation PhosphoSitePlus
S1002 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 18669648, 19007248
S1012 Phosphorylation HPRD   PhosphoSitePlus 18491316
S1016 Phosphorylation PhosphoSitePlus
K1058 Sumoylation PhosphoSitePlus
K1058 Ubiquitination PhosphoSitePlus
T1062 Phosphorylation Q13315 (ATM) HPRD   neXtProt   phospho.ELM   PhosphoSitePlus 17525332, 11756551
T1064 Phosphorylation IEDB   PhosphoSitePlus   UniProt 35494241, 23186163
S1093 Phosphorylation PhosphoSitePlus
C1099 S-Nitrosylation dbSNO 26338901
T1105 Phosphorylation PhosphoSitePlus
S1126 Phosphorylation PhosphoSitePlus
S1138 Phosphorylation Q13315 (ATM) HPRD   neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P 17525332, 11756551, 23897887
S1159 Phosphorylation P31749 (AKT1) IntAct   neXtProt   PhosphoSitePlus   RLIMS-P 35124372, 33556369, 19477925, ...17006541, 24081328, 17913746
S1183 Phosphorylation PhosphoSitePlus
S1192 Phosphorylation PhosphoSitePlus
S1216 Phosphorylation PhosphoSitePlus
T1221 Phosphorylation HPRD   PhosphoSitePlus 20068231
T1231 Phosphorylation PhosphoSitePlus
K1253 Ubiquitination PhosphoSitePlus
K1265 Ubiquitination PhosphoSitePlus
K1289 Ubiquitination PhosphoSitePlus
K1297 Ubiquitination PhosphoSitePlus
K1317 Ubiquitination PhosphoSitePlus
K1412 Methylation PhosphoSitePlus
K1421 Ubiquitination PhosphoSitePlus
K1432 Ubiquitination PhosphoSitePlus
K1443 Ubiquitination PhosphoSitePlus
K1445 Ubiquitination PhosphoSitePlus
C1463 Methylation IEDB 31844290
S1504 Phosphorylation PhosphoSitePlus   UniProt 23186163
K1506 Ubiquitination PhosphoSitePlus


PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation P54132 (BLM) S304 Q92547 (TOPBP1) unknown eFIP 25794620
Phosphorylation Q13535 (ATR) T1989 Q92547 (TOPBP1) unknown eFIP 29163782
Phosphorylation Q14676 (MDC1) S168 Q92547 (TOPBP1) unknown eFIP 30898438
Phosphorylation Q92547 (TOPBP1) S1159 Q13535 (ATR) inhibited_association eFIP 22481935
Phosphorylation Q99638 (RAD9A) S387 Q92547 (TOPBP1) unknown eFIP 30295604
Phosphorylation Q99638 (RAD9A) S341 Q92547 (TOPBP1) unknown eFIP 26658951
Phosphorylation Q99638 (RAD9A) S341 Q92547 (TOPBP1) unknown eFIP 25091155
Phosphorylation Q9UPP1 (PHF8) S854 Q92547 (TOPBP1) inhibited_association eFIP 33952527


Proteoform PPIs

Protein 1 Relation Protein 2 Source PMID
PR:P29590-5 (hPML/iso:5) Interaction PR:Q92547 (hTOPBP1) PRO 12773567


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S153 G153 Biomuta DOID:10534 / stomach cancer [ cosmic ]
T188 N188 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
T188 A188 Biomuta DOID:3571 / liver cancer [ cosmic ]
K247 E247 Biomuta DOID:10534 / stomach cancer [ cosmic ]
K247 N247 Biomuta DOID:3571 / liver cancer [ cosmic ]
S370 C370 Biomuta DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ]
S499 F499 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
S499 C499 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]
K581 R581 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
S587 N587 Biomuta DOID:4159 / skin cancer [ cosmic ]
T742 I742 Biomuta DOID:1319 / brain cancer [ icgc ]
S747 N747 Biomuta DOID:4159 / skin cancer [ cosmic ]
T776 I776 Biomuta DOID:4159 / skin cancer [ cosmic ]
T776 P776 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S805 F805 Biomuta DOID:8618 / oral cavity cancer [ cosmic ]
S817 * Biomuta DOID:1612 / breast cancer [ cosmic ]
S817 L817 Biomuta DOID:9256 / colorectal cancer [ cosmic ] DOID:1324 / lung cancer [ cosmic, icgc ]
S836 Y836 Biomuta DOID:363 / uterine cancer [ icgc ]
S836 F836 Biomuta DOID:8618 / oral cavity cancer [ cosmic ]
S853 N853 Biomuta DOID:263 / kidney cancer [ cosmic ]
T861 M861 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ] DOID:10534 / stomach cancer [ cosmic, icgc ]
S864 * Biomuta DOID:10534 / stomach cancer [ cosmic ]
S879 F879 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
S888 R888 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
T1105 I1105 Biomuta DOID:5041 / esophageal cancer [ cosmic ]
S1192 L1192 Biomuta DOID:8618 / oral cavity cancer [ cosmic ]
S1192 * Biomuta DOID:4159 / skin cancer [ cosmic ]
S1216 Y1216 Biomuta DOID:263 / kidney cancer [ cosmic, icgc ]
T1231 M1231 Biomuta DOID:9256 / colorectal cancer [ cosmic ]