iPTMnet Report for Q92540 (SMG7)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q92540 / SMG7_HUMAN
Protein Name Nonsense-mediated mRNA decay factor SMG7
Gene Name Name: SMG7
Synonyms:C1orf16;
Organism Homo sapiens (Human)

PRO ID PR:Q92540
DAG View
PRO Name nonsense-mediated mRNA decay factor SMG7 (human)
Definition A nonsense-mediated mRNA decay factor SMG7 that is encoded in the genome of human.
Short Label hSMG7
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q92540 (SMG7) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S2 Acetylation UniProt 19413330, 22814378, 22223895
K16 Ubiquitination PhosphoSitePlus
K23 Ubiquitination PhosphoSitePlus
K42 Ubiquitination PhosphoSitePlus
Y50 Phosphorylation PhosphoSitePlus
K54 Ubiquitination PhosphoSitePlus
K55 Ubiquitination PhosphoSitePlus
K66 Ubiquitination PhosphoSitePlus
K77 Ubiquitination PhosphoSitePlus
C119 Methylation IEDB 31844290
K122 Ubiquitination PhosphoSitePlus
K216 Ubiquitination PhosphoSitePlus
K228 Ubiquitination PhosphoSitePlus
K232 Ubiquitination PhosphoSitePlus
K243 Ubiquitination PhosphoSitePlus
K264 Ubiquitination PhosphoSitePlus
K268 Ubiquitination PhosphoSitePlus
K275 Ubiquitination PhosphoSitePlus
K438 Ubiquitination PhosphoSitePlus
K447 Ubiquitination PhosphoSitePlus
K464 Ubiquitination PhosphoSitePlus
S520 Phosphorylation PhosphoSitePlus   UniProt 18691976
K524 Ubiquitination PhosphoSitePlus
S528 Phosphorylation PhosphoSitePlus
S534 Phosphorylation PhosphoSitePlus
T539 Phosphorylation PhosphoSitePlus
K542 Ubiquitination PhosphoSitePlus
K581 Acetylation PhosphoSitePlus
K585 Acetylation PhosphoSitePlus
T624 O-Glycosylation GlyGen 35138101, 30379171, 32574038, ...34019948, 29351928, 35132862, 31492838, 35289036, 35254053, 22661428, 29237092, 30059200
T624 Phosphorylation PhosphoSitePlus   UniProt 23186163
S627 O-Glycosylation GlyGen 29351928, 35138101, 34019948, ...30379171, 32574038, 30059200, 35254053, 35132862, 31492838, 35289036, 30620550, 22661428, 29237092
T632 O-Glycosylation GlyGen 35138101, 30379171, 32574038, ...34019948, 29351928, 35132862, 31492838, 35289036, 35254053, 22661428, 29237092, 30059200
K780 Ubiquitination PhosphoSitePlus
S781 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18691976, 21406692, 23186163, ...17081983, 19690332
S786 Phosphorylation PhosphoSitePlus
Y791 Phosphorylation PhosphoSitePlus
K798 Ubiquitination PhosphoSitePlus
K812 Ubiquitination PhosphoSitePlus
K817 Ubiquitination PhosphoSitePlus
Y820 Phosphorylation PhosphoSitePlus
K847 Ubiquitination PhosphoSitePlus
K865 Ubiquitination PhosphoSitePlus
S897 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163
R902 Methylation PhosphoSitePlus
R910 Methylation PhosphoSitePlus
S928 Phosphorylation PhosphoSitePlus
S929 Phosphorylation PhosphoSitePlus
S930 Phosphorylation PhosphoSitePlus
S938 Phosphorylation PhosphoSitePlus
R943 Methylation PhosphoSitePlus
S948 O-Glycosylation GlyGen 29351928, 35138101, 34019948, ...30379171, 32574038, 30059200, 35254053, 35132862, 31492838, 35289036, 30620550, 22661428, 29237092
Y954 Phosphorylation PhosphoSitePlus
K956 Ubiquitination PhosphoSitePlus
S1075 Phosphorylation PhosphoSitePlus
T1076 Phosphorylation PhosphoSitePlus
S1078 Phosphorylation PhosphoSitePlus
K1123 Ubiquitination PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S520 Phosphorylation HPRD 18691976
S781 Phosphorylation HPRD 19651622, 18691976, 17081983, ...20068231
S786 Phosphorylation HPRD 20068231
S897 Phosphorylation HPRD 18669648
S929 Phosphorylation HPRD 18452278
S938 Phosphorylation HPRD 18452278
Site PTM Type PTM Enzyme Score Source PMID
S520 Phosphorylation HPRD 18691976
S735 Phosphorylation HPRD 19651622, 18691976, 17081983, ...20068231
S740 Phosphorylation HPRD 20068231
S851 Phosphorylation HPRD 18669648
S883 Phosphorylation HPRD 18452278
S892 Phosphorylation HPRD 18452278
Site PTM Type PTM Enzyme Score Source PMID
K871 Ubiquitination PhosphoSitePlus
K919 Ubiquitination PhosphoSitePlus


PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation P04637 (TP53) S378 Q92540 (SMG7) unknown eFIP 27462439


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K66 N66 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
K77 E77 Biomuta DOID:1319 / brain cancer [ cosmic, icgc ]
K438 E438 Biomuta DOID:9256 / colorectal cancer [ icgc ]
K524 I524 Biomuta DOID:263 / kidney cancer [ cosmic, icgc ]
Y820 F820 Biomuta DOID:263 / kidney cancer [ cosmic, icgc ]
Y820 C820 Biomuta [ cosmic ]
S883 F883 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
S929 F929 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
K956 E956 Biomuta DOID:1319 / brain cancer [ icgc ]
S1075 N1075 Biomuta DOID:263 / kidney cancer [ cosmic, icgc ]