iPTMnet Report for Q92522 (H1-10)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q92522 / H1X_HUMAN
Protein Name Histone H1.10
Gene Name Name: H1-10
Synonyms:H1FX;
Organism Homo sapiens (Human)

PRO ID PR:Q92522
DAG View
PRO Name histone H1.10 (human)
Definition A histone H1.10 that is encoded in the genome of human.
Short Label hH1-10
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q92522 (H1-10) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S2 Acetylation UniProt 19413330, 21406692, 22223895
S2 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 21406692, 23186163, 17081983, ...19691289
K20 Ubiquitination PhosphoSitePlus
T22 Phosphorylation PhosphoSitePlus
K23 Ubiquitination PhosphoSitePlus
S27 Phosphorylation HPRD   PhosphoSitePlus 20068231
S31 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 17322306, 17081983, 17287340, ...18212344, 15302935, 19664995, 19007248, 19651622, 18669648, 21406692, 24275569, 23186163, 17924679, 19690332, 20068231, 19691289
S33 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 21406692, 17081983, 19007248, ...19691289, 20068231
K34 Ubiquitination PhosphoSitePlus
K47 Acetylation PhosphoSitePlus   UniProt 19608861
K47 Ubiquitination PhosphoSitePlus
R57 Methylation PhosphoSitePlus
K76 Ubiquitination PhosphoSitePlus
K90 Ubiquitination PhosphoSitePlus
T101 O-Glycosylation GlyGen 21224338, 33214551, 34019948, ...34229054
K106 Ubiquitination PhosphoSitePlus
S113 O-Glycosylation GlyGen 29351928
S113 Phosphorylation PhosphoSitePlus
K115 Ubiquitination PhosphoSitePlus
R128 Methylation PhosphoSitePlus
K143 Ubiquitination PhosphoSitePlus
K145 Ubiquitination PhosphoSitePlus
K146 Methylation PhosphoSitePlus
K146 Ubiquitination PhosphoSitePlus
K174 Acetylation PhosphoSitePlus
K179 Acetylation PhosphoSitePlus
K180 Acetylation PhosphoSitePlus
K182 Acetylation PhosphoSitePlus
K185 Acetylation PhosphoSitePlus
K188 Methylation PhosphoSitePlus
K195 Acetylation PhosphoSitePlus
K196 Acetylation PhosphoSitePlus
K196 Methylation PhosphoSitePlus
K198 Acetylation PhosphoSitePlus
K199 Acetylation PhosphoSitePlus
K202 Ubiquitination PhosphoSitePlus
K207 Methylation PhosphoSitePlus
K210 Methylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
T22 P22 Biomuta DOID:2394 / ovarian cancer [ cosmic ]
S31 P31 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S33 C33 Biomuta DOID:5041 / esophageal cancer [ cosmic ]
K146 N146 Biomuta DOID:8618 / oral cavity cancer [ cosmic ] DOID:11934 / head and neck cancer [ icgc ]
K179 N179 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
K188 N188 Biomuta DOID:263 / kidney cancer [ cosmic, icgc ]
K199 R199 Biomuta DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ]