iPTMnet Report for Q92508 (PIEZO1)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q92508 / PIEZ1_HUMAN
Protein Name Piezo-type mechanosensitive ion channel component 1
Gene Name Name: PIEZO1
Synonyms:FAM38A,KIAA0233;
Organism Homo sapiens (Human)

PRO ID PR:Q92508
DAG View
PRO Name piezo-type mechanosensitive ion channel component 1 (human)
Definition A piezo-type mechanosensitive ion channel component 1 that is encoded in the genome of human.
Short Label hPIEZO1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q92508 (PIEZO1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K113 Ubiquitination PhosphoSitePlus
S165 Phosphorylation PhosphoSitePlus
T167 Phosphorylation PhosphoSitePlus
T175 Phosphorylation PhosphoSitePlus
T179 Phosphorylation PhosphoSitePlus
C262 Methylation IEDB 31844290
C296 Methylation IEDB 31844290
K346 Ubiquitination PhosphoSitePlus
K540 Ubiquitination PhosphoSitePlus
S732 Phosphorylation PhosphoSitePlus
T734 Phosphorylation PhosphoSitePlus   UniProt 23186163
S758 Phosphorylation PhosphoSitePlus   UniProt 23186163
Y821 Phosphorylation PhosphoSitePlus
T822 Phosphorylation PhosphoSitePlus
T1016 Phosphorylation PhosphoSitePlus
T1027 Phosphorylation PhosphoSitePlus
C1064 Methylation IEDB 31844290
Y1165 Phosphorylation PhosphoSitePlus
Y1195 Phosphorylation PhosphoSitePlus
K1267 Acetylation PhosphoSitePlus
K1334 Ubiquitination PhosphoSitePlus
K1345 Ubiquitination PhosphoSitePlus
K1351 Ubiquitination PhosphoSitePlus
K1360 Ubiquitination PhosphoSitePlus
K1381 Ubiquitination PhosphoSitePlus
S1391 Phosphorylation PhosphoSitePlus   UniProt 18669648, 23186163, 20068231
S1395 Phosphorylation PhosphoSitePlus
S1396 Phosphorylation PhosphoSitePlus   UniProt 23186163
T1479 Phosphorylation PhosphoSitePlus
S1509 Phosphorylation PhosphoSitePlus
T1510 Phosphorylation PhosphoSitePlus
S1619 Phosphorylation PhosphoSitePlus
S1621 Phosphorylation PhosphoSitePlus
T1626 Phosphorylation PhosphoSitePlus
S1636 Phosphorylation PhosphoSitePlus   UniProt 23186163
Y1638 Phosphorylation PhosphoSitePlus
T1644 Phosphorylation PhosphoSitePlus
S1646 Phosphorylation IEDB   PhosphoSitePlus   UniProt 35494241, 23186163, 18669648, ...24275569, 19690332, 20068231
C1691 Methylation IEDB 31844290
S1820 Phosphorylation PhosphoSitePlus
T1854 Phosphorylation PhosphoSitePlus   UniProt 18669648, 23186163
S1870 Phosphorylation IEDB 27920218, 30784271, 29493099
K1903 Ubiquitination PhosphoSitePlus
K1953 Ubiquitination PhosphoSitePlus
N2294 N-Glycosylation GlyGen   UniProt 24190977, 19349973
K2313 Ubiquitination PhosphoSitePlus
N2331 N-Glycosylation GlyGen 24190977
K2372 Ubiquitination PhosphoSitePlus
K2479 Ubiquitination PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K113 E113 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
K346 N346 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
C1064 * Biomuta DOID:3571 / liver cancer [ cosmic ]
Y1195 * Biomuta DOID:1319 / brain cancer [ cosmic ]
K1381 N1381 Biomuta DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ]
S1509 R1509 Biomuta DOID:4606 / bile duct cancer [ cosmic ]