Protein Information

Cytoscape View

UniProt AC / UniProt ID Q92466 / DDB2_HUMAN
Protein Name DNA damage-binding protein 2
Gene Name Name: DDB2
Organism Homo sapiens (Human)

PRO ID PR:Q92466
DAG View
PRO Name DNA damage-binding protein 2 (human)
Definition A DNA damage-binding protein 2 that is encoded in the genome of human.
Short Label hDDB2
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species

Q92466 (DDB2) as Substrate

Site PTM Type PTM Enzyme Score Source PMID
Ubiquitination PRO
S24 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163, 17081983
S26 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 21406692, 23186163, 17081983, ...18669648, 19690332, 20068231
K40 Ubiquitination PhosphoSitePlus
S50 Phosphorylation PhosphoSitePlus
K106 Ubiquitination PhosphoSitePlus
S116 Phosphorylation PhosphoSitePlus
T122 Phosphorylation PhosphoSitePlus
S131 Phosphorylation PhosphoSitePlus
K146 Ubiquitination PhosphoSitePlus
K151 Ubiquitination PhosphoSitePlus
K163 Ubiquitination PhosphoSitePlus
K187 Sumoylation PhosphoSitePlus
K187 Ubiquitination PhosphoSitePlus
K278 Acetylation PhosphoSitePlus
K278 Ubiquitination PhosphoSitePlus
S297 Phosphorylation PhosphoSitePlus
K309 Acetylation PhosphoSitePlus
K309 Sumoylation PhosphoSitePlus
K309 Ubiquitination PhosphoSitePlus
T338 Phosphorylation PhosphoSitePlus
K341 Ubiquitination PhosphoSitePlus
K362 Methylation PhosphoSitePlus
K362 Ubiquitination PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S24 Phosphorylation HPRD 17081983, 18452278, 19651622, ...18669648, 20166139, 20068231
S26 Phosphorylation HPRD 17322306, 20058876, 18767875, ...19664994, 18452278, 19651622, 18669648, 18707149, 20166139, 19415658, 20068231


PRO ID (Short Label) Sites PTM Enzyme Source PMID
PR:000047151 (hDDB2/UbiqLys+) ub PRO

PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation O95251 (KAT7) S50 Q92466 (DDB2) unknown eFIP 28719581

PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S26 R26 Biomuta DOID:2531 / hematologic cancer [ tcga ]
S26 I26 Biomuta DOID:3571 / liver cancer [ icgc ]
T338 P338 Biomuta DOID:2394 / ovarian cancer [ tcga ] DOID:2994 / germ cell cancer [ cosmic ]
K341 N341 Biomuta DOID:9256 / colorectal cancer [ icgc ]