iPTMnet Report for Q92187 (ST8SIA4)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q92187 / SIA8D_HUMAN
Protein Name CMP-N-acetylneuraminate-poly-alpha-2,8-sialyltransferase
Gene Name Name: ST8SIA4
Synonyms:PST,PST1,SIAT8D;
Organism Homo sapiens (Human)

PRO ID PR:Q92187
DAG View
PRO Name CMP-N-acetylneuraminate-poly-alpha-2,8-sialyltransferase (human)
Definition A CMP-N-acetylneuraminate-poly-alpha-2,8-sialyltransferase that is encoded in the genome of human.
Short Label hST8SIA4
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q92187 (ST8SIA4) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K58 Ubiquitination PhosphoSitePlus
N74 N-Glycosylation GlyGen   UniProt 11279095, 24190977
K99 Ubiquitination PhosphoSitePlus
Y110 Phosphorylation IEDB   PhosphoSitePlus 27869121
N119 N-Glycosylation GlyGen 24190977
N204 N-Glycosylation GlyGen 24190977
S216 Phosphorylation PhosphoSitePlus
N219 N-Glycosylation GlyGen 24190977
T253 Phosphorylation PhosphoSitePlus
Y267 Phosphorylation PhosphoSitePlus
T270 Phosphorylation PhosphoSitePlus
C292 Methylation IEDB 31844290


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K58 N58 Biomuta DOID:10534 / stomach cancer [ cosmic ]
Y110 F110 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
Y110 H110 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
N119 T119 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S216 F216 Biomuta DOID:4159 / skin cancer [ cosmic ]
S216 Y216 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]