iPTMnet Report for Q8WZ73 (RFFL)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q8WZ73 / RFFL_HUMAN
Protein Name E3 ubiquitin-protein ligase rififylin
Gene Name Name: RFFL
Synonyms:RNF189,RNF34L;
Organism Homo sapiens (Human)

PRO ID PR:Q8WZ73
DAG View
PRO Name E3 ubiquitin-protein ligase rififylin (human)
Definition An E3 ubiquitin-protein ligase rififylin that is encoded in the genome of human.
Short Label hRFFL
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q8WZ73 (RFFL) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
Y29 Phosphorylation PhosphoSitePlus
S30 Phosphorylation PhosphoSitePlus
Y34 Phosphorylation phospho.ELM   PhosphoSitePlus 18083107
S36 Phosphorylation PhosphoSitePlus
S39 Phosphorylation PhosphoSitePlus
T57 Phosphorylation PhosphoSitePlus
K105 Acetylation PhosphoSitePlus
K126 Ubiquitination PhosphoSitePlus
S149 Phosphorylation PhosphoSitePlus
T150 Phosphorylation PhosphoSitePlus
S152 Phosphorylation PhosphoSitePlus
Y211 Phosphorylation PhosphoSitePlus
T224 Phosphorylation PhosphoSitePlus
S226 Phosphorylation PhosphoSitePlus   UniProt 19690332
S229 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 15302935, 19690332, 24275569
S232 Phosphorylation PhosphoSitePlus
S240 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S242 Phosphorylation PhosphoSitePlus
T245 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
K259 Ubiquitination PhosphoSitePlus
K270 Ubiquitination PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
Y34 Phosphorylation HPRD 18083107, 19901323
S226 Phosphorylation HPRD 19651622, 20166139
S229 Phosphorylation HPRD 19651622, 20166139, 15302935, ...19415658
S240 Phosphorylation HPRD 18578522, 20058876, 18452278, ...19651622, 18669648, 20166139, 20068231
S242 Phosphorylation HPRD 20166139, 18578522, 20058876, ...17081983
T245 Phosphorylation HPRD 19651622, 20166139, 18578522, ...18669648


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S36 F36 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]
S240 F240 Biomuta DOID:4159 / skin cancer [ cosmic ]
S240 C240 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
S240 P240 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S242 C242 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]