iPTMnet Report for Q8WZ64 (ARAP2)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q8WZ64 / ARAP2_HUMAN
Protein Name Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 2
Gene Name Name: ARAP2
Synonyms:CENTD1,KIAA0580;
Organism Homo sapiens (Human)

PRO ID PR:Q8WZ64
DAG View
PRO Name Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 2 (human)
Definition An Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 2 that is encoded in the genome of human.
Short Label hARAP2
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q8WZ64 (ARAP2) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S52 Phosphorylation PhosphoSitePlus
S69 Phosphorylation PhosphoSitePlus
Y77 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 16497976
C216 Methylation IEDB 31844290
Y258 Phosphorylation PhosphoSitePlus
S279 Phosphorylation PhosphoSitePlus
S295 Phosphorylation PhosphoSitePlus
T296 Phosphorylation PhosphoSitePlus
S302 Phosphorylation PhosphoSitePlus
Y303 Phosphorylation PhosphoSitePlus
S346 O-Glycosylation GlyGen 36240223
S350 Phosphorylation PhosphoSitePlus
T357 Phosphorylation PhosphoSitePlus
Y380 Phosphorylation PhosphoSitePlus
K391 Ubiquitination PhosphoSitePlus
K439 Methylation PhosphoSitePlus
Y451 Phosphorylation HPRD 16497976
Y473 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 16497976
Y477 Phosphorylation HPRD   PhosphoSitePlus 16497976
S493 Phosphorylation PhosphoSitePlus
S577 Phosphorylation HPRD   PhosphoSitePlus 18077418
S580 Phosphorylation HPRD   PhosphoSitePlus 18077418
S582 Phosphorylation HPRD   PhosphoSitePlus 18077418
T587 Phosphorylation PhosphoSitePlus
Y593 Phosphorylation PhosphoSitePlus
K600 Acetylation PhosphoSitePlus
K616 Acetylation PhosphoSitePlus
Y654 Phosphorylation PhosphoSitePlus
S729 Phosphorylation PhosphoSitePlus
S781 Phosphorylation PhosphoSitePlus
Y867 Phosphorylation PhosphoSitePlus
K922 Methylation PhosphoSitePlus
T1186 Phosphorylation PhosphoSitePlus
K1219 Ubiquitination PhosphoSitePlus
T1320 Phosphorylation PhosphoSitePlus
K1437 Ubiquitination PhosphoSitePlus
S1600 Phosphorylation HPRD   phospho.ELM 17081983
S1632 Phosphorylation PhosphoSitePlus
T1692 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S69 * Biomuta DOID:4159 / skin cancer [ cosmic ]
S279 F279 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S295 L295 Biomuta DOID:8618 / oral cavity cancer [ cosmic ]
S302 I302 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
S346 F346 Biomuta DOID:4159 / skin cancer [ cosmic ]
K391 M391 Biomuta DOID:3571 / liver cancer [ cosmic ]
S580 L580 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
S582 C582 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
K922 I922 Biomuta DOID:10283 / prostate cancer [ cosmic ]
T1186 M1186 Biomuta DOID:10283 / prostate cancer [ cosmic ] DOID:1324 / lung cancer [ cosmic ]
T1320 I1320 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S1600 F1600 Biomuta [ cosmic ]