iPTMnet Report for Q8WYR1 (PIK3R5)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q8WYR1 / PI3R5_HUMAN
Protein Name Phosphoinositide 3-kinase regulatory subunit 5
Gene Name Name: PIK3R5
Organism Homo sapiens (Human)

PRO ID PR:Q8WYR1
DAG View
PRO Name phosphoinositide 3-kinase regulatory subunit 5 (human)
Definition A phosphoinositide 3-kinase regulatory subunit 5 that is encoded in the genome of human.
Short Label hPIK3R5
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q8WYR1 (PIK3R5) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
C20 Methylation IEDB 31844290
T114 Phosphorylation PhosphoSitePlus
S121 Phosphorylation PhosphoSitePlus
K256 Ubiquitination PhosphoSitePlus
K263 Ubiquitination PhosphoSitePlus
K429 Ubiquitination PhosphoSitePlus
S430 Phosphorylation PhosphoSitePlus
S432 Phosphorylation PhosphoSitePlus
S440 Phosphorylation PhosphoSitePlus
S447 Phosphorylation PhosphoSitePlus
S458 Phosphorylation PhosphoSitePlus   UniProt 19369195
S468 Phosphorylation PhosphoSitePlus
S507 Phosphorylation PhosphoSitePlus   UniProt 19369195
K562 Ubiquitination PhosphoSitePlus
K758 Ubiquitination PhosphoSitePlus
K782 Acetylation PhosphoSitePlus
K825 Ubiquitination PhosphoSitePlus
C833 Methylation IEDB 31844290


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K263 Q263 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S432 R432 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
S447 L447 Biomuta DOID:8618 / oral cavity cancer [ cosmic ] DOID:9256 / colorectal cancer [ cosmic ]
S458 C458 Biomuta DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ]
K825 R825 Biomuta DOID:10534 / stomach cancer [ cosmic ]
K825 N825 Biomuta DOID:363 / uterine cancer [ icgc ]