iPTMnet Report for Q8WYQ5 (DGCR8)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q8WYQ5 / DGCR8_HUMAN
Protein Name Microprocessor complex subunit DGCR8
Gene Name Name: DGCR8
Synonyms:C22orf12,DGCRK6;ORFNames:LP4941;
Organism Homo sapiens (Human)

PRO ID PR:Q8WYQ5
DAG View
PRO Name microprocessor complex subunit DGCR8 (human)
Definition A microprocessor complex subunit DGCR8 that is encoded in the genome of human.
Short Label hDGCR8
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q8WYQ5 (DGCR8) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S6 Phosphorylation PhosphoSitePlus
S8 Phosphorylation PhosphoSitePlus
S35 Phosphorylation PhosphoSitePlus   UniProt 24275569
S92 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 24275569, 18220336
S95 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 21406692, 23186163, 18669648, ...18220336
S109 Phosphorylation phospho.ELM   PhosphoSitePlus   RLIMS-P 18669648, 26202964
K113 Ubiquitination PhosphoSitePlus
S123 Phosphorylation PhosphoSitePlus
T125 Phosphorylation PhosphoSitePlus
K134 Ubiquitination PhosphoSitePlus
S153 Phosphorylation PhosphoSitePlus   RLIMS-P 28380355, 26202964
K259 Sumoylation PhosphoSitePlus
Y267 Phosphorylation phospho.ELM   PhosphoSitePlus   RLIMS-P+   Signor 18669648, 26126715
Y267 Phosphorylation P00519 (ABL1) RLIMS-P+   Signor 26126715
S271 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 19690332
S275 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163, 19690332
T279 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S280 Phosphorylation PhosphoSitePlus
S339 Phosphorylation PhosphoSitePlus
S367 Phosphorylation PhosphoSitePlus
S368 Phosphorylation PhosphoSitePlus
T371 Phosphorylation PhosphoSitePlus   RLIMS-P   UniProt 21406692, 26202964
S373 Phosphorylation PhosphoSitePlus   UniProt 23186163
S377 Phosphorylation phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 18669648, 26202964, 23186163, ...21406692
K380 Ubiquitination PhosphoSitePlus
S383 Phosphorylation PhosphoSitePlus
S385 Phosphorylation PhosphoSitePlus
S397 Phosphorylation PhosphoSitePlus
K424 Ubiquitination PhosphoSitePlus
K431 Ubiquitination PhosphoSitePlus
S434 Phosphorylation PhosphoSitePlus
K474 Ubiquitination PhosphoSitePlus
K488 Ubiquitination PhosphoSitePlus
S493 Phosphorylation PhosphoSitePlus
S545 Phosphorylation PhosphoSitePlus
T547 Phosphorylation PhosphoSitePlus
K582 Ubiquitination PhosphoSitePlus
S619 Phosphorylation PhosphoSitePlus
C627 Methylation IEDB 31844290
K640 Ubiquitination PhosphoSitePlus
K647 Ubiquitination PhosphoSitePlus
K659 Ubiquitination PhosphoSitePlus
S677 Phosphorylation PhosphoSitePlus   RLIMS-P 34188037
K707 Sumoylation PhosphoSitePlus
S711 Phosphorylation PhosphoSitePlus
K713 Ubiquitination PhosphoSitePlus
S714 Phosphorylation PhosphoSitePlus
K726 Ubiquitination PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S92 Phosphorylation HPRD 18669648
S95 Phosphorylation HPRD 18669648
S109 Phosphorylation HPRD 18669648, 20068231
Y267 Phosphorylation HPRD 19413330, 18669648, 20068231, ...18452278
S271 Phosphorylation HPRD 19413330, 19651622, 18669648, ...20068231, 18452278
S275 Phosphorylation HPRD 19651622, 18669648, 20068231, ...18452278
T279 Phosphorylation HPRD 18669648, 18452278
S373 Phosphorylation HPRD 19651622, 18452278
S377 Phosphorylation HPRD 19651622, 18669648, 20068231, ...18452278
S383 Phosphorylation HPRD 17081983


PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation Q8WYQ5 (DGCR8) S677 Q70EK9 (USP51) unknown eFIP 34188037
Phosphorylation Q9NRR4 (DROSHA) S300 Q8WYQ5 (DGCR8) unknown eFIP 27907888


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S6 N6 Biomuta DOID:1612 / breast cancer [ cosmic ]
S92 R92 Biomuta DOID:263 / kidney cancer [ cosmic ]
S95 I95 Biomuta DOID:1319 / brain cancer [ icgc ]
S95 N95 Biomuta DOID:363 / uterine cancer [ icgc ]
S109 F109 Biomuta DOID:4159 / skin cancer [ cosmic ]
S123 R123 Biomuta DOID:3571 / liver cancer [ cosmic ]
S123 N123 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
K134 T134 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
Y267 C267 Biomuta DOID:263 / kidney cancer [ cosmic ]
S271 N271 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
T547 I547 Biomuta [ cosmic ]
S619 F619 Biomuta DOID:4362 / cervical cancer [ cosmic, icgc ]
K659 R659 Biomuta DOID:5041 / esophageal cancer [ cosmic ]