iPTMnet Report for Q8WXH0 (SYNE2)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q8WXH0 / SYNE2_HUMAN
Protein Name Nesprin-2
Gene Name Name: SYNE2
Synonyms:KIAA1011,NUA;
Organism Homo sapiens (Human)

PRO ID PR:Q8WXH0
DAG View
PRO Name nesprin-2 (human)
Definition A nesprin-2 that is encoded in the genome of human.
Short Label hSYNE2
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q8WXH0 (SYNE2) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
T49 Phosphorylation PhosphoSitePlus
S50 Phosphorylation PhosphoSitePlus
S52 Phosphorylation PhosphoSitePlus
T59 Phosphorylation PhosphoSitePlus
S162 Phosphorylation PhosphoSitePlus
S165 Phosphorylation PhosphoSitePlus
S166 Phosphorylation PhosphoSitePlus
R224 Methylation PhosphoSitePlus
K254 Ubiquitination PhosphoSitePlus
K318 Ubiquitination PhosphoSitePlus
K361 Ubiquitination PhosphoSitePlus
K508 Acetylation PhosphoSitePlus
K529 Ubiquitination PhosphoSitePlus
Y546 Phosphorylation PhosphoSitePlus
K558 Ubiquitination PhosphoSitePlus
Y560 Phosphorylation PhosphoSitePlus
Y570 Phosphorylation PhosphoSitePlus
Y575 Phosphorylation PhosphoSitePlus
K578 Ubiquitination PhosphoSitePlus
S663 Phosphorylation PhosphoSitePlus
T665 Phosphorylation PhosphoSitePlus
K676 Methylation PhosphoSitePlus
S705 Phosphorylation PhosphoSitePlus
T764 Phosphorylation PhosphoSitePlus
K771 Ubiquitination PhosphoSitePlus
S841 Phosphorylation PhosphoSitePlus   UniProt 24275569
Y860 Phosphorylation PhosphoSitePlus
S873 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
K882 Acetylation PhosphoSitePlus
K955 Acetylation PhosphoSitePlus   UniProt 19608861
C982 Methylation IEDB 31844290
S1008 O-Glycosylation GlyGen 30379171, 25367160, 29351928
K1010 Ubiquitination PhosphoSitePlus
S1090 O-Glycosylation GlyGen 30379171, 25367160, 29351928
S1102 O-Glycosylation GlyGen 30379171, 25367160, 29351928
S1111 Phosphorylation PhosphoSitePlus
T1138 Phosphorylation PhosphoSitePlus
S1139 Phosphorylation PhosphoSitePlus
C1275 Methylation IEDB 31844290
S1331 Phosphorylation PhosphoSitePlus
T1334 Phosphorylation PhosphoSitePlus
K1336 Ubiquitination PhosphoSitePlus
K1452 Acetylation PhosphoSitePlus
K1456 Acetylation PhosphoSitePlus
S1469 Phosphorylation PhosphoSitePlus
Y1480 Phosphorylation PhosphoSitePlus
T1610 Phosphorylation PhosphoSitePlus
K1618 Ubiquitination PhosphoSitePlus
K1664 Ubiquitination PhosphoSitePlus
S1738 Phosphorylation PhosphoSitePlus
K1758 Acetylation PhosphoSitePlus
S1772 Phosphorylation PhosphoSitePlus
K1816 Ubiquitination PhosphoSitePlus
K1829 Ubiquitination PhosphoSitePlus
K1859 Ubiquitination PhosphoSitePlus
K1877 Ubiquitination PhosphoSitePlus
K1892 Ubiquitination PhosphoSitePlus
K1936 Ubiquitination PhosphoSitePlus
K1957 Ubiquitination PhosphoSitePlus
T1976 Phosphorylation PhosphoSitePlus
K1986 Ubiquitination PhosphoSitePlus
T2024 Phosphorylation PhosphoSitePlus
S2030 Phosphorylation PhosphoSitePlus
K2090 Ubiquitination PhosphoSitePlus
K2114 Ubiquitination PhosphoSitePlus
T2115 Phosphorylation PhosphoSitePlus
T2117 Phosphorylation PhosphoSitePlus
K2164 Ubiquitination PhosphoSitePlus
K2178 Ubiquitination PhosphoSitePlus
K2191 Ubiquitination PhosphoSitePlus
K2200 Ubiquitination PhosphoSitePlus
K2214 Ubiquitination PhosphoSitePlus
K2291 Ubiquitination PhosphoSitePlus
S2300 Phosphorylation PhosphoSitePlus
T2305 Phosphorylation PhosphoSitePlus
K2314 Ubiquitination PhosphoSitePlus
K2317 Acetylation PhosphoSitePlus
K2317 Ubiquitination PhosphoSitePlus
K2326 Ubiquitination PhosphoSitePlus
K2333 Ubiquitination PhosphoSitePlus
R2345 Methylation PhosphoSitePlus
T2374 Phosphorylation PhosphoSitePlus
S2420 Phosphorylation PhosphoSitePlus
K2435 Ubiquitination PhosphoSitePlus
K2460 Ubiquitination PhosphoSitePlus
K2468 Ubiquitination PhosphoSitePlus
K2469 Ubiquitination PhosphoSitePlus
K2473 Ubiquitination PhosphoSitePlus
T2478 Phosphorylation PhosphoSitePlus
K2515 Ubiquitination PhosphoSitePlus
K2543 Ubiquitination PhosphoSitePlus
K2547 Ubiquitination PhosphoSitePlus
K2559 Ubiquitination PhosphoSitePlus
K2562 Ubiquitination PhosphoSitePlus
K2578 Ubiquitination PhosphoSitePlus
S2585 Phosphorylation PhosphoSitePlus
K2601 Ubiquitination PhosphoSitePlus
K2616 Ubiquitination PhosphoSitePlus
K2617 Ubiquitination PhosphoSitePlus
S2655 Phosphorylation phospho.ELM   PhosphoSitePlus 17081983
S2664 Phosphorylation PhosphoSitePlus
T2669 Phosphorylation PhosphoSitePlus
T2675 Phosphorylation PhosphoSitePlus
K2676 Ubiquitination PhosphoSitePlus
K2691 Ubiquitination PhosphoSitePlus
K2697 Ubiquitination PhosphoSitePlus
K2700 Ubiquitination PhosphoSitePlus
K2710 Ubiquitination PhosphoSitePlus
K2711 Ubiquitination PhosphoSitePlus
K2728 Ubiquitination PhosphoSitePlus
T2739 Phosphorylation PhosphoSitePlus
K2769 Ubiquitination PhosphoSitePlus
S2781 Phosphorylation PhosphoSitePlus   UniProt 21406692, 20068231
S2784 Phosphorylation PhosphoSitePlus
K2821 Ubiquitination PhosphoSitePlus
T2934 Phosphorylation PhosphoSitePlus
K2951 Acetylation PhosphoSitePlus
K2951 Ubiquitination PhosphoSitePlus
K2975 Ubiquitination PhosphoSitePlus
K2978 Ubiquitination PhosphoSitePlus
K2985 Ubiquitination PhosphoSitePlus
K3036 Ubiquitination PhosphoSitePlus
T3040 Phosphorylation PhosphoSitePlus
K3047 Ubiquitination PhosphoSitePlus
K3054 Ubiquitination PhosphoSitePlus
T3066 Phosphorylation PhosphoSitePlus
K3071 Acetylation PhosphoSitePlus
K3071 Ubiquitination PhosphoSitePlus
S3075 Phosphorylation PhosphoSitePlus
S3076 Phosphorylation PhosphoSitePlus
K3116 Ubiquitination PhosphoSitePlus
S3145 Phosphorylation PhosphoSitePlus
K3157 Ubiquitination PhosphoSitePlus
K3183 Ubiquitination PhosphoSitePlus
K3229 Ubiquitination PhosphoSitePlus
Y3255 Phosphorylation PhosphoSitePlus
S3321 Phosphorylation PhosphoSitePlus
S3322 Phosphorylation PhosphoSitePlus
K3339 Ubiquitination PhosphoSitePlus
K3344 Ubiquitination PhosphoSitePlus
K3362 Ubiquitination PhosphoSitePlus
Y3364 Phosphorylation PhosphoSitePlus
Y3372 Phosphorylation PhosphoSitePlus
K3497 Ubiquitination PhosphoSitePlus
S3659 Phosphorylation PhosphoSitePlus
K3681 Ubiquitination PhosphoSitePlus
K3691 Ubiquitination PhosphoSitePlus
T3777 Phosphorylation PhosphoSitePlus
K3782 Ubiquitination PhosphoSitePlus
Y3790 Phosphorylation PhosphoSitePlus
S3796 Phosphorylation PhosphoSitePlus
S3816 Phosphorylation PhosphoSitePlus
S3821 Phosphorylation PhosphoSitePlus
S3843 Phosphorylation PhosphoSitePlus
S3881 Phosphorylation PhosphoSitePlus
T3911 Phosphorylation PhosphoSitePlus
S3915 Phosphorylation IEDB 32387766
K3978 Ubiquitination PhosphoSitePlus
T3984 Phosphorylation PhosphoSitePlus
K3992 Ubiquitination PhosphoSitePlus
K4053 Ubiquitination PhosphoSitePlus
K4072 Ubiquitination PhosphoSitePlus
S4108 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 19690332
S4110 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
Y4111 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S4126 Phosphorylation PhosphoSitePlus
S4136 Phosphorylation PhosphoSitePlus
S4139 Phosphorylation PhosphoSitePlus
S4156 Phosphorylation PhosphoSitePlus
S4157 Phosphorylation PhosphoSitePlus
S4158 Phosphorylation PhosphoSitePlus
S4159 Phosphorylation PhosphoSitePlus
T4161 Phosphorylation PhosphoSitePlus
Y4167 Phosphorylation PhosphoSitePlus
T4182 Phosphorylation PhosphoSitePlus
T4284 Phosphorylation PhosphoSitePlus
K4348 Ubiquitination PhosphoSitePlus
K4629 Ubiquitination PhosphoSitePlus
S4732 Phosphorylation PhosphoSitePlus
K4780 Ubiquitination PhosphoSitePlus
Y4796 Phosphorylation PhosphoSitePlus
S4797 Phosphorylation PhosphoSitePlus
S4803 Phosphorylation PhosphoSitePlus
K4839 Ubiquitination PhosphoSitePlus
Y4847 Phosphorylation PhosphoSitePlus
K4891 Acetylation PhosphoSitePlus
K4930 Ubiquitination PhosphoSitePlus
R5027 Methylation PhosphoSitePlus
T5038 Phosphorylation PhosphoSitePlus
T5042 Phosphorylation PhosphoSitePlus
S5087 Phosphorylation PhosphoSitePlus
K5100 Ubiquitination PhosphoSitePlus
K5222 Ubiquitination PhosphoSitePlus
K5257 Ubiquitination PhosphoSitePlus
S5259 Phosphorylation PhosphoSitePlus
T5293 Phosphorylation PhosphoSitePlus
K5364 Ubiquitination PhosphoSitePlus
K5632 Ubiquitination PhosphoSitePlus
T5719 Phosphorylation PhosphoSitePlus
Y5735 Phosphorylation PhosphoSitePlus
S5785 Phosphorylation PhosphoSitePlus   UniProt 24275569
K6029 Ubiquitination PhosphoSitePlus
S6043 Phosphorylation PhosphoSitePlus
K6173 Ubiquitination PhosphoSitePlus
T6234 O-Glycosylation GlyGen 30379171, 25367160, 29351928
S6314 Phosphorylation PhosphoSitePlus
T6348 Phosphorylation PhosphoSitePlus
S6349 Phosphorylation PhosphoSitePlus
T6351 Phosphorylation PhosphoSitePlus
S6361 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 20068231, 24275569, 17081983
T6365 Phosphorylation PhosphoSitePlus
S6377 Phosphorylation PhosphoSitePlus
S6384 Phosphorylation PhosphoSitePlus
S6389 Phosphorylation PhosphoSitePlus
S6392 Phosphorylation PhosphoSitePlus
S6453 Phosphorylation PhosphoSitePlus
S6459 Phosphorylation PhosphoSitePlus   UniProt 24275569
S6483 Phosphorylation PhosphoSitePlus
S6484 O-Glycosylation GlyGen 30379171, 25367160, 29351928
S6484 Phosphorylation PhosphoSitePlus
T6485 O-Glycosylation GlyGen 30379171, 25367160, 29351928
T6485 Phosphorylation PhosphoSitePlus
Y6487 Phosphorylation PhosphoSitePlus
K6546 Ubiquitination PhosphoSitePlus
S6616 Phosphorylation PhosphoSitePlus
S6625 Phosphorylation PhosphoSitePlus
K6693 Ubiquitination PhosphoSitePlus
T6807 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S873 Phosphorylation HPRD 18669648
S1331 Phosphorylation HPRD 20068231
Y1638 Phosphorylation HPRD 20068231
T1976 Phosphorylation HPRD 20068231
S2655 Phosphorylation HPRD 17081983
S2781 Phosphorylation HPRD 20068231
T2934 Phosphorylation HPRD 20068231
T3040 Phosphorylation HPRD 20068231
Y3790 Phosphorylation HPRD 20068231
S3949 Phosphorylation HPRD 20068231
S4108 Phosphorylation HPRD 18669648, 20068231
S4110 Phosphorylation HPRD 18669648
Y4111 Phosphorylation HPRD 18669648
S4136 Phosphorylation HPRD 20068231
S4139 Phosphorylation HPRD 20068231
T4161 Phosphorylation HPRD 19691289
T4495 Phosphorylation HPRD 20068231
T5038 Phosphorylation HPRD 20068231
T5042 Phosphorylation HPRD 20068231
Y5282 Phosphorylation HPRD 20068231
T5293 Phosphorylation HPRD 20068231
S6361 Phosphorylation HPRD 19651622, 17081983, 20068231
S6384 Phosphorylation HPRD 17081983
S6388 Phosphorylation HPRD 17081983
S6389 Phosphorylation HPRD 17081983
S6392 Phosphorylation HPRD 17081983
Site PTM Type PTM Enzyme Score Source PMID
S873 Phosphorylation HPRD 18669648
S1331 Phosphorylation HPRD 20068231
Y1638 Phosphorylation HPRD 20068231
T1976 Phosphorylation HPRD 20068231
S2655 Phosphorylation HPRD 17081983
S2781 Phosphorylation HPRD 20068231
T2934 Phosphorylation HPRD 20068231
T3040 Phosphorylation HPRD 20068231
Y3790 Phosphorylation HPRD 20068231
S3949 Phosphorylation HPRD 20068231
S4108 Phosphorylation HPRD 18669648, 20068231
S4110 Phosphorylation HPRD 18669648
Y4111 Phosphorylation HPRD 18669648
S4136 Phosphorylation HPRD 20068231
S4139 Phosphorylation HPRD 20068231
T4161 Phosphorylation HPRD 19691289
T4495 Phosphorylation HPRD 20068231
T5038 Phosphorylation HPRD 20068231
T5042 Phosphorylation HPRD 20068231
Y5282 Phosphorylation HPRD 20068231
T5293 Phosphorylation HPRD 20068231
S6361 Phosphorylation HPRD 19651622, 17081983, 20068231
S6384 Phosphorylation HPRD 17081983
S6388 Phosphorylation HPRD 17081983
S6389 Phosphorylation HPRD 17081983
S6392 Phosphorylation HPRD 17081983
Site PTM Type PTM Enzyme Score Source PMID
S18 Phosphorylation HPRD 17081983
S22 Phosphorylation HPRD 17081983
S23 Phosphorylation HPRD 17081983
S26 Phosphorylation HPRD 17081983


PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation Q16658 (FSCN1) S39 Q8WXH0 (SYNE2) increased_association eFIP 28060557


Proteoform PPIs

Protein 1 Relation Protein 2 Source PMID
PR:Q8WXH0-4 (hSYNE2/iso:4) Interaction PR:Q9D666 (mSUN1) PRO 19933576
PR:Q8WXH0-5 (hSYNE2/iso:5) Interaction PR:Q9UH99 (hSUN2) PRO 19933576
PR:Q8WXH0-5 (hSYNE2/iso:5) Interaction PR:Q9D666 (mSUN1) PRO 19933576


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
T49 A49 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
S52 L52 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
R224 G224 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]
K361 N361 Biomuta DOID:1324 / lung cancer [ cosmic ]
Y575 * Biomuta DOID:3571 / liver cancer [ cosmic ]
S663 L663 Biomuta DOID:10283 / prostate cancer [ cosmic, icgc ]
S663 * Biomuta DOID:4159 / skin cancer [ cosmic ]
K676 E676 Biomuta DOID:8618 / oral cavity cancer [ cosmic ]
K771 N771 Biomuta DOID:1319 / brain cancer [ icgc ]
S841 L841 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
T1138 A1138 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
S1139 Y1139 Biomuta DOID:363 / uterine cancer [ icgc ]
K1452 T1452 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
K1456 Q1456 Biomuta DOID:10534 / stomach cancer [ cosmic ]
S1469 L1469 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
T1610 I1610 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
K1758 R1758 Biomuta DOID:4362 / cervical cancer [ cosmic ]
K1829 N1829 Biomuta DOID:4606 / bile duct cancer [ cosmic ]
K1986 N1986 Biomuta DOID:1612 / breast cancer [ cosmic ]
K2090 N2090 Biomuta DOID:8618 / oral cavity cancer [ cosmic ] DOID:11934 / head and neck cancer [ icgc ]
K2200 N2200 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
K2317 E2317 Biomuta DOID:9256 / colorectal cancer [ cosmic ] DOID:3571 / liver cancer [ cosmic ]
K2326 Q2326 Biomuta DOID:1324 / lung cancer [ cosmic ]
R2345 K2345 Biomuta DOID:8618 / oral cavity cancer [ cosmic ] DOID:1319 / brain cancer [ cosmic ]
S2420 C2420 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
K2469 * Biomuta DOID:263 / kidney cancer [ cosmic ]
T2478 S2478 Biomuta DOID:3571 / liver cancer [ cosmic ]
S2664 R2664 Biomuta DOID:10534 / stomach cancer [ cosmic ]
K2676 E2676 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
K2821 * Biomuta DOID:1324 / lung cancer [ cosmic ]
K3116 N3116 Biomuta DOID:263 / kidney cancer [ cosmic, icgc ]
K3116 R3116 Biomuta DOID:2531 / hematologic cancer [ icgc ]
K3229 N3229 Biomuta DOID:263 / kidney cancer [ cosmic ]
Y3255 D3255 Biomuta DOID:8618 / oral cavity cancer [ cosmic ]
K3339 E3339 Biomuta DOID:3571 / liver cancer [ cosmic ]
S3659 Y3659 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S4158 F4158 Biomuta DOID:263 / kidney cancer [ cosmic, icgc ]
Y4167 C4167 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
K5257 N5257 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
Y5735 C5735 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
S6043 C6043 Biomuta DOID:2394 / ovarian cancer [ cosmic, icgc ]
K6173 R6173 Biomuta DOID:3571 / liver cancer [ cosmic, icgc ]
S6361 F6361 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
S6459 N6459 Biomuta DOID:4159 / skin cancer [ cosmic ]
S6483 P6483 Biomuta DOID:1319 / brain cancer [ cosmic, icgc ]
S6483 A6483 Biomuta DOID:1319 / brain cancer [ cosmic, icgc ]
S6484 G6484 Biomuta DOID:11615 / penile cancer [ cosmic ]
K6546 E6546 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
K6546 N6546 Biomuta DOID:1319 / brain cancer [ cosmic, icgc ]
K6693 M6693 Biomuta DOID:1324 / lung cancer [ cosmic ]