iPTMnet Report for Q8WXG6 (MADD)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q8WXG6 / MADD_HUMAN
Protein Name MAP kinase-activating death domain protein
Gene Name Name: MADD
Synonyms:DENN;
Organism Homo sapiens (Human)

PRO ID PR:Q8WXG6
DAG View
PRO Name MAP kinase-activating death domain protein (human)
Definition A MAP kinase-activating death domain protein that is encoded in the genome of human.
Short Label hMADD
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q8WXG6 (MADD) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S156 Phosphorylation PhosphoSitePlus   UniProt 23186163
T228 Phosphorylation PhosphoSitePlus
S230 Phosphorylation PhosphoSitePlus
S262 Phosphorylation PhosphoSitePlus
K425 Ubiquitination PhosphoSitePlus
K429 Ubiquitination PhosphoSitePlus
K541 Ubiquitination PhosphoSitePlus
S599 Phosphorylation PhosphoSitePlus
S613 Phosphorylation PhosphoSitePlus
S631 Phosphorylation PhosphoSitePlus
S636 Phosphorylation PhosphoSitePlus
S669 Phosphorylation PhosphoSitePlus
S689 Phosphorylation PhosphoSitePlus
S692 Phosphorylation PhosphoSitePlus   UniProt 23186163
S709 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 18669648
S741 Phosphorylation PhosphoSitePlus
S745 Phosphorylation PhosphoSitePlus
S762 Phosphorylation PhosphoSitePlus
Y772 Phosphorylation PhosphoSitePlus
S801 Phosphorylation PhosphoSitePlus
S813 Phosphorylation PhosphoSitePlus
S818 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 18669648
S820 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 18669648
S824 Phosphorylation PhosphoSitePlus
S826 O-Glycosylation GlyGen 28657654, 29351928
S826 Phosphorylation PhosphoSitePlus
S829 Phosphorylation PhosphoSitePlus
S830 Phosphorylation PhosphoSitePlus
T834 O-Glycosylation GlyGen 28657654, 29351928
S848 Phosphorylation HPRD 20068231
S858 Phosphorylation HPRD   PhosphoSitePlus   UniProt 23186163, 20068231
S860 Phosphorylation PhosphoSitePlus
S862 Phosphorylation PhosphoSitePlus   UniProt 23186163
T867 Phosphorylation PhosphoSitePlus
K871 Methylation PhosphoSitePlus
K876 Ubiquitination PhosphoSitePlus
S882 Phosphorylation PhosphoSitePlus
K914 Ubiquitination PhosphoSitePlus
S916 Phosphorylation PhosphoSitePlus   UniProt 23186163
K919 Ubiquitination PhosphoSitePlus
S921 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163
T923 Phosphorylation PhosphoSitePlus
S930 Phosphorylation PhosphoSitePlus
K964 Ubiquitination PhosphoSitePlus
S972 Phosphorylation PhosphoSitePlus
S981 Phosphorylation PhosphoSitePlus
S1059 Phosphorylation PhosphoSitePlus   UniProt 23186163
T1061 Phosphorylation PhosphoSitePlus
S1063 Phosphorylation PhosphoSitePlus
T1066 Phosphorylation PhosphoSitePlus
K1070 Ubiquitination PhosphoSitePlus
S1110 Phosphorylation PhosphoSitePlus
K1131 Acetylation PhosphoSitePlus
K1144 Acetylation PhosphoSitePlus
S1157 Phosphorylation PhosphoSitePlus
T1168 Phosphorylation PhosphoSitePlus
S1170 Phosphorylation PhosphoSitePlus
T1174 Phosphorylation PhosphoSitePlus
S1178 Phosphorylation PhosphoSitePlus
S1183 Phosphorylation PhosphoSitePlus
T1199 Phosphorylation HPRD 18691976, 18669648, 19415658, ...18452278
S1213 Phosphorylation PhosphoSitePlus
S1233 Phosphorylation PhosphoSitePlus
S1234 Phosphorylation PhosphoSitePlus
T1237 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163
S1239 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163
S1241 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
T1245 Phosphorylation PhosphoSitePlus
S1258 Phosphorylation PhosphoSitePlus
K1260 Ubiquitination PhosphoSitePlus
S1262 Phosphorylation PhosphoSitePlus
S1270 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163
S1279 Phosphorylation PhosphoSitePlus
S1354 Phosphorylation PhosphoSitePlus
S1380 Phosphorylation PhosphoSitePlus
Y1381 Phosphorylation PhosphoSitePlus
Y1488 Phosphorylation PhosphoSitePlus
S1503 Phosphorylation PhosphoSitePlus
K1537 Ubiquitination PhosphoSitePlus
K1608 Ubiquitination PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S709 Phosphorylation HPRD 18669648
S818 Phosphorylation HPRD 18669648
S820 Phosphorylation HPRD 18669648
S848 Phosphorylation HPRD 20068231
S858 Phosphorylation HPRD 20068231
S921 Phosphorylation HPRD 18669648
S1059 Phosphorylation HPRD 19651622, 19664994, 20068231
T1174 Phosphorylation HPRD 20068231
S1183 Phosphorylation HPRD 20068231
T1237 Phosphorylation HPRD 18691976, 18669648, 19415658, ...18452278
S1239 Phosphorylation HPRD 19664994, 18669648, 20058876, ...18452278
S1241 Phosphorylation HPRD 18669648, 20068231
S1270 Phosphorylation HPRD 18669648
S1275 Phosphorylation HPRD 20068231
Site PTM Type PTM Enzyme Score Source PMID
S709 Phosphorylation HPRD 18669648
S818 Phosphorylation HPRD 18669648
S820 Phosphorylation HPRD 18669648
S848 Phosphorylation HPRD 20068231
S858 Phosphorylation HPRD 20068231
S921 Phosphorylation HPRD 18669648
S1059 Phosphorylation HPRD 19651622, 19664994, 20068231
S1110 Phosphorylation PhosphoSitePlus
T1156 Phosphorylation HPRD 20068231
S1165 Phosphorylation HPRD 20068231
T1219 Phosphorylation HPRD 18691976, 18669648, 19415658, ...18452278
S1221 Phosphorylation HPRD 19664994, 18669648, 20058876, ...18452278
S1223 Phosphorylation HPRD 18669648, 20068231
S1252 Phosphorylation HPRD 18669648
S1257 Phosphorylation HPRD 20068231
Site PTM Type PTM Enzyme Score Source PMID
S709 Phosphorylation HPRD 18669648
S818 Phosphorylation HPRD 18669648
S820 Phosphorylation HPRD 18669648
S848 Phosphorylation HPRD 20068231
S858 Phosphorylation HPRD 20068231
K884 Methylation PhosphoSitePlus
S901 Phosphorylation HPRD 18669648
S1039 Phosphorylation HPRD 19651622, 19664994, 20068231
S1090 Phosphorylation PhosphoSitePlus
T1136 Phosphorylation HPRD 20068231
S1145 Phosphorylation HPRD 20068231
T1198 Phosphorylation HPRD 18691976, 18669648, 19415658, ...18452278
S1200 Phosphorylation HPRD 19664994, 18669648, 20058876, ...18452278
S1202 Phosphorylation HPRD 18669648, 20068231
S1231 Phosphorylation HPRD 18669648
S1236 Phosphorylation HPRD 20068231
Site PTM Type PTM Enzyme Score Source PMID
S709 Phosphorylation HPRD 18669648
S775 Phosphorylation HPRD 18669648
S777 Phosphorylation HPRD 18669648
S805 Phosphorylation HPRD 20068231
S815 Phosphorylation HPRD 20068231
S878 Phosphorylation HPRD 18669648
S1016 Phosphorylation HPRD 19651622, 19664994, 20068231
T1113 Phosphorylation HPRD 20068231
S1122 Phosphorylation HPRD 20068231
T1176 Phosphorylation HPRD 18691976, 18669648, 19415658, ...18452278
S1178 Phosphorylation HPRD 19664994, 18669648, 20058876, ...18452278
S1180 Phosphorylation HPRD 18669648, 20068231
S1209 Phosphorylation HPRD 18669648
S1214 Phosphorylation HPRD 20068231
Site PTM Type PTM Enzyme Score Source PMID
S709 Phosphorylation HPRD 18669648
S775 Phosphorylation HPRD 18669648
S777 Phosphorylation HPRD 18669648
S805 Phosphorylation HPRD 20068231
S815 Phosphorylation HPRD 20068231
S858 Phosphorylation HPRD 18669648
S996 Phosphorylation HPRD 19651622, 19664994, 20068231
T1093 Phosphorylation HPRD 20068231
S1102 Phosphorylation HPRD 20068231
T1156 Phosphorylation HPRD 18691976, 18669648, 19415658, ...18452278
S1158 Phosphorylation HPRD 19664994, 18669648, 20058876, ...18452278
S1160 Phosphorylation HPRD 18669648, 20068231
S1189 Phosphorylation HPRD 18669648
S1194 Phosphorylation HPRD 20068231
Site PTM Type PTM Enzyme Score Source PMID
S709 Phosphorylation HPRD 18669648
S775 Phosphorylation HPRD 18669648
S777 Phosphorylation HPRD 18669648
S805 Phosphorylation HPRD 20068231
S815 Phosphorylation HPRD 20068231
K841 Methylation PhosphoSitePlus
S858 Phosphorylation HPRD 18669648
S996 Phosphorylation HPRD 19651622, 19664994, 20068231
S1047 Phosphorylation PhosphoSitePlus
T1093 Phosphorylation HPRD 20068231
S1102 Phosphorylation HPRD 20068231
T1156 Phosphorylation HPRD 18691976, 18669648, 19415658, ...18452278
S1158 Phosphorylation HPRD 19664994, 18669648, 20058876, ...18452278
S1160 Phosphorylation HPRD 18669648, 20068231
S1189 Phosphorylation HPRD 18669648
S1194 Phosphorylation HPRD 20068231
K1475 Methylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S709 Phosphorylation HPRD 18669648
S818 Phosphorylation HPRD 18669648
S820 Phosphorylation HPRD 18669648
S848 Phosphorylation HPRD 20068231
S858 Phosphorylation HPRD 20068231
S921 Phosphorylation HPRD 18669648
S1059 Phosphorylation HPRD 19651622, 19664994, 20068231
T1174 Phosphorylation HPRD 20068231
S1183 Phosphorylation HPRD 20068231
T1237 Phosphorylation HPRD 18691976, 18669648, 19415658, ...18452278
S1239 Phosphorylation HPRD 19664994, 18669648, 20058876, ...18452278
S1241 Phosphorylation HPRD 18669648, 20068231
S1270 Phosphorylation HPRD 18669648
S1275 Phosphorylation HPRD 20068231


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
T228 I228 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S230 L230 Biomuta DOID:5041 / esophageal cancer [ cosmic ]
S801 I801 Biomuta DOID:3571 / liver cancer [ cosmic ]
S826 T826 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S916 Y916 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
T923 A923 Biomuta DOID:5041 / esophageal cancer [ cosmic ]
T1168 S1168 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
S1189 N1189 Biomuta DOID:4159 / skin cancer [ cosmic, cosmic, cosmic ]
T1199 I1199 Biomuta DOID:4159 / skin cancer [ cosmic ]
S1209 N1209 Biomuta DOID:4159 / skin cancer [ cosmic ]
S1231 N1231 Biomuta DOID:4159 / skin cancer [ cosmic ]
S1252 N1252 Biomuta DOID:4159 / skin cancer [ cosmic ]
S1270 N1270 Biomuta DOID:4159 / skin cancer [ cosmic ]
S1380 T1380 Biomuta DOID:4362 / cervical cancer [ cosmic, icgc ]
K1537 I1537 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
K1608 E1608 Biomuta DOID:9256 / colorectal cancer [ cosmic ]