iPTMnet Report for Q8WXE1 (ATRIP)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q8WXE1 / ATRIP_HUMAN
Protein Name ATR-interacting protein
Gene Name Name: ATRIP
Synonyms:AGS1;
Organism Homo sapiens (Human)

PRO ID PR:Q8WXE1
DAG View
PRO Name ATR-interacting protein (human)
Definition An ATR-interacting protein that is encoded in the genome of human.
Short Label hATRIP
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q8WXE1 (ATRIP) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S9 Phosphorylation PhosphoSitePlus
S13 Phosphorylation PhosphoSitePlus
T26 Phosphorylation PhosphoSitePlus
S31 Phosphorylation PhosphoSitePlus
K32 Acetylation PhosphoSitePlus
S38 Phosphorylation PhosphoSitePlus
S68 Phosphorylation neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor 15451423, 23723247
S68 Phosphorylation Q13535 (ATR) neXtProt   phospho.ELM   PhosphoSitePlus   Signor 15451423
S72 Phosphorylation neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor 15451423, 23723247
S72 Phosphorylation Q13535 (ATR) neXtProt   phospho.ELM   PhosphoSitePlus   Signor 15451423
K96 Ubiquitination PhosphoSitePlus
K122 Ubiquitination PhosphoSitePlus
S162 Phosphorylation PhosphoSitePlus
K205 Ubiquitination PhosphoSitePlus
K214 Ubiquitination PhosphoSitePlus
S219 Phosphorylation PhosphoSitePlus
S221 Phosphorylation PhosphoSitePlus
S224 Phosphorylation neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor 17638878, 18669648
S224 Phosphorylation P24941 (CDK2) phospho.ELM   PhosphoSitePlus   Signor 17638878
S239 Phosphorylation phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor 17638878, 17616665
S239 Phosphorylation P24941 (CDK2) phospho.ELM   Signor 17638878
K270 Ubiquitination PhosphoSitePlus
K295 Ubiquitination PhosphoSitePlus
S305 Phosphorylation PhosphoSitePlus
T307 Phosphorylation PhosphoSitePlus
S310 Phosphorylation PhosphoSitePlus
S449 Phosphorylation PhosphoSitePlus
S512 Phosphorylation PhosphoSitePlus
S518 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
T523 Phosphorylation PhosphoSitePlus
Y636 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S68 Phosphorylation HPRD 15451423
S68 Phosphorylation Q13535 (ATR) HPRD 15451423
S72 Phosphorylation HPRD 15451423
S72 Phosphorylation Q13535 (ATR) HPRD 15451423
S221 Phosphorylation HPRD 20068231
S224 Phosphorylation HPRD 19651622, 18669648, 19664995, ...20068231
S305 Phosphorylation HPRD 18452278
T307 Phosphorylation HPRD 18452278
S310 Phosphorylation HPRD 18452278
S518 Phosphorylation HPRD 18669648, 20068231, 18452278
T523 Phosphorylation HPRD 20068231
Site PTM Type PTM Enzyme Score Source PMID
S68 Phosphorylation HPRD 15451423
S68 Phosphorylation Q13535 (ATR) HPRD 15451423
S72 Phosphorylation HPRD 15451423
S72 Phosphorylation Q13535 (ATR) HPRD 15451423
S221 Phosphorylation HPRD 20068231
S224 Phosphorylation HPRD 19651622, 18669648, 19664995, ...20068231
S305 Phosphorylation HPRD 18452278
T307 Phosphorylation HPRD 18452278
S310 Phosphorylation HPRD 18452278
S518 Phosphorylation HPRD 18669648, 20068231, 18452278
T523 Phosphorylation HPRD 20068231
T664 Phosphorylation PhosphoSitePlus


PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation Q8WXE1 (ATRIP) S239 P38398 (BRCA1) unknown eFIP 17616665


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S72 R72 Biomuta DOID:1324 / lung cancer [ icgc ]
S72 T72 Biomuta DOID:8618 / oral cavity cancer [ cosmic, cosmic ] DOID:4159 / skin cancer [ cosmic ] DOID:1324 / lung cancer [ icgc ] DOID:2531 / hematologic cancer [ cosmic, icgc ]
K214 T214 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S310 F310 Biomuta DOID:4159 / skin cancer [ cosmic ] DOID:2531 / hematologic cancer [ cosmic, icgc ]