iPTMnet Report for Q8WXA9 (SREK1)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q8WXA9 / SREK1_HUMAN
Protein Name Splicing regulatory glutamine/lysine-rich protein 1
Gene Name Name: SREK1
Synonyms:SFRS12,SRRP86;
Organism Homo sapiens (Human)

PRO ID PR:Q8WXA9
DAG View
PRO Name splicing regulatory glutamine/lysine-rich protein 1 (human)
Definition A splicing factor, arginine/serine-rich 12 that is encoded in the genome of human.
Short Label hSREK1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q8WXA9 (SREK1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K146 Ubiquitination PhosphoSitePlus
T151 Phosphorylation PhosphoSitePlus
S171 Phosphorylation PhosphoSitePlus   UniProt 23186163
S181 Phosphorylation PhosphoSitePlus
S184 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163
T363 Phosphorylation PhosphoSitePlus   UniProt 23186163
R387 Methylation PhosphoSitePlus
R394 Methylation PhosphoSitePlus
S403 Phosphorylation PhosphoSitePlus
S404 Phosphorylation PhosphoSitePlus
S406 Phosphorylation PhosphoSitePlus
S408 Phosphorylation PhosphoSitePlus
S427 Phosphorylation PhosphoSitePlus
S435 Phosphorylation PhosphoSitePlus
T436 Phosphorylation PhosphoSitePlus
S437 Phosphorylation PhosphoSitePlus
S441 Phosphorylation PhosphoSitePlus
S442 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S181 Phosphorylation HPRD 20068231
S184 Phosphorylation HPRD 18669648, 20068231
S404 Phosphorylation HPRD 19651622
S406 Phosphorylation HPRD 19651622, 17081983
S408 Phosphorylation HPRD 19651622, 17081983
S411 Phosphorylation HPRD 17081983
Site PTM Type PTM Enzyme Score Source PMID
S62 Phosphorylation HPRD 20068231
S297 Phosphorylation HPRD 20068231
S300 Phosphorylation HPRD 18669648, 20068231
S520 Phosphorylation HPRD 19651622
S522 Phosphorylation HPRD 19651622, 17081983
S524 Phosphorylation HPRD 19651622, 17081983
S527 Phosphorylation HPRD 17081983


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S184 I184 Biomuta DOID:3571 / liver cancer [ cosmic ]
S300 I300 Biomuta DOID:3571 / liver cancer [ cosmic ]
S403 Y403 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S408 P408 Biomuta DOID:10534 / stomach cancer [ cosmic ]
S524 P524 Biomuta DOID:10534 / stomach cancer [ cosmic ]