iPTMnet Report for Q8WXA3 (RUFY2)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q8WXA3 / RUFY2_HUMAN
Protein Name RUN and FYVE domain-containing protein 2
Gene Name Name: RUFY2
Synonyms:KIAA1537,RABIP4R;
Organism Homo sapiens (Human)

PRO ID PR:Q8WXA3
DAG View
PRO Name RUN and FYVE domain-containing protein 2 (human)
Definition A RUN and FYVE domain-containing protein 2 that is encoded in the genome of human.
Short Label hRUFY2
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q8WXA3 (RUFY2) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K4 Ubiquitination PhosphoSitePlus
K19 Ubiquitination PhosphoSitePlus
S63 Phosphorylation PhosphoSitePlus
Y121 Phosphorylation PhosphoSitePlus
S221 Phosphorylation PhosphoSitePlus
S222 Phosphorylation PhosphoSitePlus
S229 Phosphorylation PhosphoSitePlus
K236 Ubiquitination PhosphoSitePlus
K245 Ubiquitination PhosphoSitePlus
T269 Phosphorylation PhosphoSitePlus
T276 Phosphorylation PhosphoSitePlus
T282 Phosphorylation PhosphoSitePlus
T286 Phosphorylation PhosphoSitePlus
K288 Ubiquitination PhosphoSitePlus
S290 Phosphorylation PhosphoSitePlus
K338 Ubiquitination PhosphoSitePlus
K343 Ubiquitination PhosphoSitePlus
K419 Acetylation PhosphoSitePlus
K427 Acetylation PhosphoSitePlus
K433 Acetylation PhosphoSitePlus
K438 Acetylation PhosphoSitePlus
T458 Phosphorylation PhosphoSitePlus
K485 Ubiquitination PhosphoSitePlus
S583 Phosphorylation PhosphoSitePlus
S592 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S268 Phosphorylation HPRD 20068231
T493 Phosphorylation HPRD 20068231, 18452278
S617 Phosphorylation HPRD 18669648
Site PTM Type PTM Enzyme Score Source PMID
S199 Phosphorylation HPRD 20068231
T376 Phosphorylation PhosphoSitePlus
T391 Phosphorylation PhosphoSitePlus
Y395 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K4 E4 Biomuta DOID:1324 / lung cancer [ cosmic ]
T286 P286 Biomuta DOID:363 / uterine cancer [ icgc ]
S290 C290 Biomuta DOID:8618 / oral cavity cancer [ cosmic ]
T376 A376 Biomuta DOID:8618 / oral cavity cancer [ cosmic ] DOID:11934 / head and neck cancer [ icgc ]
S592 T592 Biomuta DOID:4362 / cervical cancer [ icgc ]
S617 F617 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]