iPTMnet Report for Q8WWW8 (GAB3)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q8WWW8 / GAB3_HUMAN
Protein Name GRB2-associated-binding protein 3
Gene Name Name: GAB3
Organism Homo sapiens (Human)

PRO ID PR:Q8WWW8
DAG View
PRO Name GRB2-associated-binding protein 3 (human)
Definition A GRB2-associated-binding protein 3 that is encoded in the genome of human.
Short Label hGAB3
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q8WWW8 (GAB3) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S198 Phosphorylation PhosphoSitePlus
S205 Phosphorylation PhosphoSitePlus
T283 Phosphorylation PhosphoSitePlus
S344 Phosphorylation PhosphoSitePlus   UniProt 23186163
K355 Ubiquitination PhosphoSitePlus
S362 Phosphorylation PhosphoSitePlus
S371 Phosphorylation PhosphoSitePlus
S466 Phosphorylation PhosphoSitePlus
S482 Phosphorylation PhosphoSitePlus   UniProt 23186163
Y506 Phosphorylation PhosphoSitePlus
T514 Phosphorylation PhosphoSitePlus
S517 Phosphorylation PhosphoSitePlus
S519 Phosphorylation PhosphoSitePlus
Y533 Phosphorylation PhosphoSitePlus
S542 Phosphorylation PhosphoSitePlus
Y560 Phosphorylation PhosphoSitePlus
K575 Ubiquitination PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S506 Phosphorylation PhosphoSitePlus
Y507 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S362 F362 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S371 T371 Biomuta DOID:4159 / skin cancer [ cosmic ]
S371 R371 Biomuta DOID:1324 / lung cancer [ cosmic ]
S371 N371 Biomuta DOID:363 / uterine cancer [ icgc ]
Y506 F506 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
Y507 F507 Biomuta DOID:1324 / lung cancer [ icgc ]
S519 T519 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
Y533 * Biomuta DOID:4159 / skin cancer [ cosmic ]
S542 P542 Biomuta DOID:263 / kidney cancer [ cosmic, icgc ]