iPTMnet Report for Q8WWL2 (SPIRE2)
Protein Information
UniProt AC / UniProt ID | Q8WWL2 / SPIR2_HUMAN |
Protein Name | Protein spire homolog 2 |
Gene Name | Name: SPIRE2 Synonyms:KIAA1832,SPIR2; |
Organism | Homo sapiens (Human) |
PRO ID | PR:Q8WWL2 |
PRO Name | protein spire homolog 2 (human) |
Definition | A protein spire homolog 2 that is encoded in the genome of human. |
Short Label | hSPIRE2 |
Category | organism-gene |
Q8WWL2 (SPIRE2) as Substrate
Site | PTM Type | PTM Enzyme |
Score
| Source | PMID | |
---|---|---|---|---|---|---|
T62 | Phosphorylation | score1 | PhosphoSitePlus | |||
S72 | Phosphorylation | score1 | PhosphoSitePlus | |||
Y291 | Phosphorylation | score1 | PhosphoSitePlus | |||
S371 | Phosphorylation | score2 | PhosphoSitePlus UniProt | 18669648, 23186163 | ||
S387 | Phosphorylation | score1 | PhosphoSitePlus | |||
S392 | Phosphorylation | score1 | PhosphoSitePlus | |||
T394 | Phosphorylation | score1 | PhosphoSitePlus | |||
S399 | Phosphorylation | score1 | PhosphoSitePlus | |||
T422 | Phosphorylation | score1 | PhosphoSitePlus | |||
S423 | Phosphorylation | score1 | PhosphoSitePlus | |||
S428 | Phosphorylation | score1 | PhosphoSitePlus | |||
S440 | Phosphorylation | score2 | PhosphoSitePlus UniProt | 23186163 | ||
S442 | Phosphorylation | score2 | PhosphoSitePlus UniProt | 18669648, 23186163 | ||
S476 | Phosphorylation | score2 | PhosphoSitePlus UniProt | 23186163 | ||
S598 | Phosphorylation | score1 | PhosphoSitePlus | |||
S600 | Phosphorylation | score1 | PhosphoSitePlus | |||
S622 | Phosphorylation | score1 | PhosphoSitePlus | |||
S627 | Phosphorylation | score1 | PhosphoSitePlus | |||
T631 | Phosphorylation | score1 | PhosphoSitePlus | |||
T693 | Phosphorylation | score1 | PhosphoSitePlus | |||
S702 | Phosphorylation | score1 | PhosphoSitePlus |
Site | PTM Type | PTM Enzyme |
Score
| Source | PMID | |
---|---|---|---|---|---|---|
T62 | Phosphorylation | score0 | HPRD | 20068231 | ||
S72 | Phosphorylation | score0 | HPRD | 20068231 | ||
S371 | Phosphorylation | score0 | HPRD | 18669648, 20068231 | ||
S440 | Phosphorylation | score0 | HPRD | 18669648, 20068231 | ||
S442 | Phosphorylation | score0 | HPRD | 19651622, 18669648 | ||
Y704 | Phosphorylation | score0 | HPRD | 20068231 |
PTM sites affected in variants
Site | Variant | Source | PMID | Disease [Sample source] |
---|---|---|---|---|
Y291 | C291 | Biomuta | DOID:1324 / lung cancer [ cosmic ] | |
S371 | Y371 | Biomuta | DOID:4606 / bile duct cancer [ cosmic ] | |
S392 | L392 | Biomuta | DOID:4159 / skin cancer [ cosmic, icgc ] | |
S423 | Y423 | Biomuta | DOID:1324 / lung cancer [ cosmic, icgc ] | |
S440 | F440 | Biomuta | DOID:4159 / skin cancer [ cosmic ] | |
S440 | C440 | Biomuta | DOID:4159 / skin cancer [ cosmic, icgc ] | |
S627 | L627 | Biomuta | DOID:11054 / urinary bladder cancer [ cosmic ] | |
T693 | K693 | Biomuta | DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ] | |
S702 | F702 | Biomuta | DOID:1612 / breast cancer [ cosmic ] |