iPTMnet Report for Q8WWL2 (SPIRE2)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q8WWL2 / SPIR2_HUMAN
Protein Name Protein spire homolog 2
Gene Name Name: SPIRE2
Synonyms:KIAA1832,SPIR2;
Organism Homo sapiens (Human)

PRO ID PR:Q8WWL2
DAG View
PRO Name protein spire homolog 2 (human)
Definition A protein spire homolog 2 that is encoded in the genome of human.
Short Label hSPIRE2
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q8WWL2 (SPIRE2) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
T62 Phosphorylation PhosphoSitePlus
S72 Phosphorylation PhosphoSitePlus
Y291 Phosphorylation PhosphoSitePlus
S371 Phosphorylation PhosphoSitePlus   UniProt 18669648, 23186163
S387 Phosphorylation PhosphoSitePlus
S392 Phosphorylation PhosphoSitePlus
T394 Phosphorylation PhosphoSitePlus
S399 Phosphorylation PhosphoSitePlus
T422 Phosphorylation PhosphoSitePlus
S423 Phosphorylation PhosphoSitePlus
S428 Phosphorylation PhosphoSitePlus
S440 Phosphorylation PhosphoSitePlus   UniProt 23186163
S442 Phosphorylation PhosphoSitePlus   UniProt 18669648, 23186163
S476 Phosphorylation PhosphoSitePlus   UniProt 23186163
S598 Phosphorylation PhosphoSitePlus
S600 Phosphorylation PhosphoSitePlus
S622 Phosphorylation PhosphoSitePlus
S627 Phosphorylation PhosphoSitePlus
T631 Phosphorylation PhosphoSitePlus
T693 Phosphorylation PhosphoSitePlus
S702 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
T62 Phosphorylation HPRD 20068231
S72 Phosphorylation HPRD 20068231
S371 Phosphorylation HPRD 18669648, 20068231
S440 Phosphorylation HPRD 18669648, 20068231
S442 Phosphorylation HPRD 19651622, 18669648
Y704 Phosphorylation HPRD 20068231


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
Y291 C291 Biomuta DOID:1324 / lung cancer [ cosmic ]
S371 Y371 Biomuta DOID:4606 / bile duct cancer [ cosmic ]
S392 L392 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S423 Y423 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
S440 F440 Biomuta DOID:4159 / skin cancer [ cosmic ]
S440 C440 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S627 L627 Biomuta DOID:11054 / urinary bladder cancer [ cosmic ]
T693 K693 Biomuta DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ]
S702 F702 Biomuta DOID:1612 / breast cancer [ cosmic ]