iPTMnet Report for Q8WW12 (PCNP)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q8WW12 / PCNP_HUMAN
Protein Name PEST proteolytic signal-containing nuclear protein
Gene Name Name: PCNP
Organism Homo sapiens (Human)

PRO ID PR:Q8WW12
DAG View
PRO Name PEST proteolytic signal-containing nuclear protein (human)
Definition A PEST proteolytic signal-containing nuclear protein that is encoded in the genome of human.
Short Label hPCNP
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q8WW12 (PCNP) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
A2 Acetylation UniProt 20154145
K5 Acetylation PhosphoSitePlus
S14 Phosphorylation PhosphoSitePlus
R16 Methylation PhosphoSitePlus
K29 Acetylation PhosphoSitePlus
K29 Ubiquitination PhosphoSitePlus
S44 O-Glycosylation GlyGen 31373491
S53 Phosphorylation PhosphoSitePlus   UniProt 23186163
T63 Phosphorylation PhosphoSitePlus
K64 Acetylation PhosphoSitePlus   UniProt 19608861
K64 Ubiquitination PhosphoSitePlus
T66 Phosphorylation phospho.ELM   PhosphoSitePlus 17287340
K67 Ubiquitination PhosphoSitePlus
S69 Phosphorylation phospho.ELM   PhosphoSitePlus 17287340
K70 Acetylation PhosphoSitePlus
K70 Methylation PhosphoSitePlus
S77 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 23186163, 17287340
T79 Phosphorylation PhosphoSitePlus
T80 Phosphorylation PhosphoSitePlus
K81 Acetylation PhosphoSitePlus
K82 Ubiquitination PhosphoSitePlus
S84 O-Glycosylation GlyGen 35132862, 35254053, 34019948, ...31492838, 32119511, 31373491, 30059200
S84 Phosphorylation PhosphoSitePlus
S87 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163
K89 Acetylation PhosphoSitePlus
S92 Phosphorylation PhosphoSitePlus
T101 O-Glycosylation GlyGen 35132862, 35254053, 34019948, ...31492838, 32119511, 31373491, 30059200
T101 Phosphorylation PhosphoSitePlus
T106 Phosphorylation PhosphoSitePlus
S108 Phosphorylation PhosphoSitePlus
S119 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163, 21406692
K133 Methylation PhosphoSitePlus
T139 O-Glycosylation GlyGen 35132862, 35254053, 34019948, ...31492838, 32119511, 31373491, 30059200
T139 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 23186163, 18669648, 17287340
T141 O-Glycosylation GlyGen 30620550
T141 Phosphorylation PhosphoSitePlus
S142 O-Glycosylation GlyGen 34019948, 30059200, 35254053, ...35132862, 31492838, 32119511, 30620550, 31373491
S142 Phosphorylation phospho.ELM   PhosphoSitePlus 17287340
S147 O-Glycosylation GlyGen 31373491
S147 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 23186163, 21406692, 17287340
K150 Acetylation PhosphoSitePlus   UniProt 19608861
K150 Methylation PhosphoSitePlus
K150 Ubiquitination PhosphoSitePlus
K152 Acetylation PhosphoSitePlus   UniProt 19608861
K152 Methylation PhosphoSitePlus
K152 Ubiquitination PhosphoSitePlus
S156 Phosphorylation PhosphoSitePlus
K160 Ubiquitination PhosphoSitePlus
K167 Acetylation PhosphoSitePlus
K167 Ubiquitination PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
T66 Phosphorylation HPRD 17287340
S69 Phosphorylation HPRD 17287340, 20068231
S77 Phosphorylation HPRD 17287340
S87 Phosphorylation HPRD 18669648
T101 Phosphorylation HPRD 20068231
S119 Phosphorylation HPRD 19413330, 17322306, 19664994, ...19651622, 18669648, 20166139, 19415658, 20068231
T139 Phosphorylation HPRD 18669648, 17287340, 17924679
S142 Phosphorylation HPRD 17287340
S147 Phosphorylation HPRD 17287340, 20068231


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
T79 M79 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S84 L84 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
S87 F87 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S87 A87 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S108 L108 Biomuta DOID:4159 / skin cancer [ cosmic ]
S142 T142 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
S147 F147 Biomuta [ cosmic ] DOID:4159 / skin cancer [ cosmic ]
K167 T167 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]