Protein Information

Cytoscape View


UniProt AC / UniProt ID Q8WVM8 / SCFD1_HUMAN
Protein Name Sec1 family domain-containing protein 1
Gene Name Name: SCFD1
Synonyms:C14orf163,KIAA0917,STXBP1L2;ORFNames:FKSG23;
Organism Homo sapiens (Human)

PRO ID PR:Q8WVM8
DAG View
PRO Name sec1 family domain-containing protein 1 (human)
Definition A sec1 family domain-containing protein 1 that is encoded in the genome of human.
Short Label hSCFD1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q8WVM8 (SCFD1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
A2 Acetylation UniProt 19413330, 22814378, 22223895, ...25944712
K24 Methylation PhosphoSitePlus
S57 Phosphorylation phospho.ELM   PhosphoSitePlus 15302935
K63 Ubiquitination PhosphoSitePlus
S113 Phosphorylation PhosphoSitePlus
Y114 Phosphorylation PhosphoSitePlus
Y115 Phosphorylation PhosphoSitePlus
K126 Ubiquitination PhosphoSitePlus
S297 Phosphorylation PhosphoSitePlus
S298 Phosphorylation PhosphoSitePlus
S303 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18691976, 23186163, 18669648, ...24275569, 20068231
K315 Ubiquitination PhosphoSitePlus
S316 Phosphorylation PhosphoSitePlus
K324 Ubiquitination PhosphoSitePlus
K330 Ubiquitination PhosphoSitePlus
S332 Phosphorylation PhosphoSitePlus
S360 Phosphorylation PhosphoSitePlus
S373 Phosphorylation PhosphoSitePlus
S376 Phosphorylation PhosphoSitePlus
T379 Phosphorylation PhosphoSitePlus
T383 Phosphorylation PhosphoSitePlus
S387 Phosphorylation PhosphoSitePlus
S388 Phosphorylation PhosphoSitePlus
K395 Ubiquitination PhosphoSitePlus
K417 Ubiquitination PhosphoSitePlus
K427 Ubiquitination PhosphoSitePlus
K431 Ubiquitination PhosphoSitePlus
K436 Ubiquitination PhosphoSitePlus
S443 Phosphorylation PhosphoSitePlus
K494 Ubiquitination PhosphoSitePlus
K501 Ubiquitination PhosphoSitePlus
Y509 Phosphorylation PhosphoSitePlus
K515 Ubiquitination PhosphoSitePlus
S528 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 17525332, 23186163
K536 Acetylation PhosphoSitePlus
K536 Ubiquitination PhosphoSitePlus
K541 Ubiquitination PhosphoSitePlus
K558 Ubiquitination PhosphoSitePlus
K572 Ubiquitination PhosphoSitePlus
R575 Methylation PhosphoSitePlus
K642 Ubiquitination PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S297 Phosphorylation HPRD 17322306, 18691976
S298 Phosphorylation HPRD 18691976, 17081983
S303 Phosphorylation HPRD 19413330, 18691976, 18767875, ...19664994, 19664995, 19651622, 18669648, 19415658, 20068231
S332 Phosphorylation HPRD 18452278
S528 Phosphorylation HPRD 17525332
Site PTM Type PTM Enzyme Score Source PMID
S230 Phosphorylation HPRD 17322306, 18691976
S231 Phosphorylation HPRD 18691976, 17081983
S236 Phosphorylation HPRD 19413330, 18691976, 18767875, ...19664994, 19664995, 19651622, 18669648, 19415658, 20068231
S265 Phosphorylation HPRD 18452278
S461 Phosphorylation HPRD 17525332


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
A2 V2 Biomuta DOID:363 / uterine cancer [ tcga ]
K63 R63 Biomuta DOID:9256 / colorectal cancer [ icgc ]
K324 T324 Biomuta DOID:363 / uterine cancer [ icgc, tcga ]
S332 N332 Biomuta DOID:9256 / colorectal cancer [ tcga ]
K417 T417 Biomuta DOID:363 / uterine cancer [ tcga ]
K501 N501 Biomuta DOID:3571 / liver cancer [ icgc ]
R575 Q575 Biomuta DOID:3571 / liver cancer [ icgc ]
R575 W575 Biomuta DOID:9256 / colorectal cancer [ tcga ] DOID:10534 / stomach cancer [ cosmic, icgc, tcga ]