iPTMnet Report for Q8WVC0 (LEO1)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q8WVC0 / LEO1_HUMAN
Protein Name RNA polymerase-associated protein LEO1
Gene Name Name: LEO1
Synonyms:RDL;
Organism Homo sapiens (Human)

PRO ID PR:Q8WVC0
DAG View
PRO Name RNA polymerase-associated protein LEO1 (human)
Definition An RNA polymerase-associated protein LEO1 that is encoded in the genome of human.
Short Label hLEO1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q8WVC0 (LEO1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
A2 Acetylation UniProt 21406692, 22814378, 20068231
S10 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 17081983, 20068231
S14 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 21406692, 17081983, 20068231
S27 Phosphorylation PhosphoSitePlus
S29 Phosphorylation phospho.ELM   PhosphoSitePlus 15302935
S66 Phosphorylation PhosphoSitePlus   UniProt 23186163
S72 Phosphorylation PhosphoSitePlus
S75 Phosphorylation PhosphoSitePlus
S77 Phosphorylation PhosphoSitePlus
S81 Phosphorylation PhosphoSitePlus
S88 Phosphorylation PhosphoSitePlus
S91 Phosphorylation PhosphoSitePlus
S102 Phosphorylation PhosphoSitePlus
S108 Phosphorylation PhosphoSitePlus
S110 Phosphorylation PhosphoSitePlus
S140 Phosphorylation PhosphoSitePlus
S151 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 21406692, 17081983, 20068231, ...16964243
S154 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 21406692, 17081983, 20068231, ...16964243
S162 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 21406692, 16964243, 20068231, ...17081983
S171 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 21406692, 16964243, 20068231, ...17081983
S179 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 21406692, 16964243, 20068231
T188 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 21406692, 23186163, 17081983, ...20068231
S197 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 21406692, 23186163, 17081983, ...20068231
S205 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 17081983
S212 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 21406692, 17081983, 20068231
S220 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 21406692, 17081983, 20068231
S229 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 17081983, 20068231
S238 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 17081983, 20068231
S246 Phosphorylation PhosphoSitePlus
S254 Phosphorylation PhosphoSitePlus
S261 Phosphorylation PhosphoSitePlus
S271 Phosphorylation PhosphoSitePlus
S273 Phosphorylation PhosphoSitePlus
S277 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 15302935, 24275569
S279 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 21406692, 23186163, 16964243, ...15302935, 18669648, 24275569, 20068231
S294 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 21406692, 17081983, 15302935, ...18669648, 24275569
S296 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 17081983, 24275569
S300 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 21406692, 17081983, 15302935, ...24275569, 20068231
T302 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648, 17081983
T356 Phosphorylation PhosphoSitePlus
K364 Ubiquitination PhosphoSitePlus
Y374 Phosphorylation PhosphoSitePlus
K377 Ubiquitination PhosphoSitePlus
K413 Ubiquitination PhosphoSitePlus
K415 Ubiquitination PhosphoSitePlus
K434 Ubiquitination PhosphoSitePlus
K442 Ubiquitination PhosphoSitePlus
K461 Ubiquitination PhosphoSitePlus
K486 Methylation PhosphoSitePlus
K486 Ubiquitination PhosphoSitePlus
K488 Ubiquitination PhosphoSitePlus
T496 Phosphorylation PhosphoSitePlus
K503 Ubiquitination PhosphoSitePlus
S546 Phosphorylation PhosphoSitePlus
S551 Phosphorylation phospho.ELM   PhosphoSitePlus 17081983
S566 Phosphorylation PhosphoSitePlus
S568 Phosphorylation PhosphoSitePlus
R574 Methylation PhosphoSitePlus
K591 Ubiquitination PhosphoSitePlus
Y606 Phosphorylation PhosphoSitePlus   UniProt 24275569
S607 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 21406692
S608 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 21406692
S610 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 21406692, 24275569
S614 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648
T629 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 17081983, 19690332
S630 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 21406692, 23186163, 16964243, ...15302935, 18669648, 24275569, 19690332, 20068231, 17081983
S637 Phosphorylation PhosphoSitePlus
S658 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 21406692, 23186163, 16964243, ...18318008, 18669648, 24275569, 19690332, 20068231, 17081983
Site PTM Type PTM Enzyme Score Source PMID
S10 Phosphorylation HPRD 19651622, 17081983, 20068231
S14 Phosphorylation HPRD 19651622, 17081983, 20068231
S29 Phosphorylation HPRD 15302935
S66 Phosphorylation HPRD 20068231
S72 Phosphorylation HPRD 17081983, 18452278
S140 Phosphorylation HPRD 20068231, 18452278
S151 Phosphorylation HPRD 19651622, 17081983, 16964243, ...20068231, 18452278
S154 Phosphorylation HPRD 19651622, 17081983, 16964243, ...20068231, 18452278
S162 Phosphorylation HPRD 17081983, 19007248, 18452278, ...19651622, 20068231, 16964243
S171 Phosphorylation HPRD 19651622, 17081983, 16964243, ...20068231, 18452278
S179 Phosphorylation HPRD 19651622, 16964243, 20068231, ...18452278
T188 Phosphorylation HPRD 17322306, 19651622, 19664994, ...20068231, 18452278
S197 Phosphorylation HPRD 19651622, 19664994, 17081983, ...20068231, 18452278
S205 Phosphorylation HPRD 19651622, 17081983, 20068231
S212 Phosphorylation HPRD 19651622, 18452278, 19007248, ...20068231, 17081983
S220 Phosphorylation HPRD 17322306, 19651622, 19007248, ...20068231, 18452278
S229 Phosphorylation HPRD 17322306, 19651622, 20068231, ...18452278
S238 Phosphorylation HPRD 19651622, 18767875, 17081983, ...20068231, 18452278
S271 Phosphorylation HPRD 17081983
S277 Phosphorylation HPRD 15302935, 18452278
S279 Phosphorylation HPRD 16964243, 15302935, 19007248, ...19651622, 18669648, 19415658, 20068231
S294 Phosphorylation HPRD 19413330, 15302935, 18452278, ...19651622, 18669648, 20068231
S296 Phosphorylation HPRD 17322306, 18767875, 18452278, ...19651622, 18669648, 20068231
S300 Phosphorylation HPRD 18767875, 15302935, 19691289, ...18452278, 19651622, 20068231
T302 Phosphorylation HPRD 19413330, 17081983, 18452278, ...19651622, 18669648, 20068231
S309 Phosphorylation HPRD 17081983
S322 Phosphorylation HPRD 17081983, 20068231
S323 Phosphorylation HPRD 17081983, 20068231
S325 Phosphorylation HPRD 17081983
T333 Phosphorylation HPRD 20068231
T356 Phosphorylation HPRD 20068231
S551 Phosphorylation HPRD 17081983
S607 Phosphorylation HPRD 19651622, 18669648, 20068231
S608 Phosphorylation HPRD 19651622, 18669648, 20068231
S610 Phosphorylation HPRD 19651622, 18669648, 20068231, ...18452278
S614 Phosphorylation HPRD 19651622, 18669648, 20068231, ...18452278
T629 Phosphorylation HPRD 19413330, 19651622, 18669648, ...17081983, 20068231
S630 Phosphorylation HPRD 19413330, 16964243, 18767875, ...15302935, 18452278, 19651622, 18669648, 20166139, 20068231, 18212344
S658 Phosphorylation HPRD 19413330, 17322306, 16964243, ...18767875, 19664994, 19691289, 18452278, 19651622, 18669648, 20166139, 19415658, 20068231


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S77 G77 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
S151 G151 Biomuta DOID:1324 / lung cancer [ cosmic ]
S197 F197 Biomuta DOID:4159 / skin cancer [ cosmic ]
S212 F212 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
S229 F229 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
S246 C246 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
S261 * Biomuta DOID:11054 / urinary bladder cancer [ cosmic ]
S300 N300 Biomuta DOID:2531 / hematologic cancer [ cosmic, icgc ]
S546 P546 Biomuta DOID:263 / kidney cancer [ cosmic ]
S551 Y551 Biomuta DOID:3571 / liver cancer [ cosmic ]
R574 P574 Biomuta DOID:5041 / esophageal cancer [ cosmic, icgc ]
R574 * Biomuta DOID:4159 / skin cancer [ cosmic ]
S607 A607 Biomuta DOID:363 / uterine cancer [ cosmic ]