iPTMnet Report for Q8WV22 (NSMCE1)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q8WV22 / NSE1_HUMAN
Protein Name Non-structural maintenance of chromosomes element 1 homolog
Gene Name Name: NSMCE1
ORFNames:HSPC333,HSPC337;
Organism Homo sapiens (Human)

PRO ID PR:Q8WV22
DAG View
PRO Name non-structural maintenance of chromosomes element 1 homolog (human)
Definition A non-structural maintenance of chromosomes element 1 that is encoded in the genome of human.
Short Label hNSMCE1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q8WV22 (NSMCE1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
T12 Phosphorylation PhosphoSitePlus
K42 Ubiquitination PhosphoSitePlus
K72 Ubiquitination PhosphoSitePlus
K143 Ubiquitination PhosphoSitePlus
K144 Ubiquitination PhosphoSitePlus
K152 Ubiquitination PhosphoSitePlus
K157 Ubiquitination PhosphoSitePlus
K218 Ubiquitination PhosphoSitePlus
K241 Ubiquitination PhosphoSitePlus
K247 Ubiquitination PhosphoSitePlus
S251 Phosphorylation PhosphoSitePlus   UniProt 23186163
S256 Phosphorylation PhosphoSitePlus
S260 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K42 R42 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
K72 N72 Biomuta DOID:1324 / lung cancer [ cosmic ]
K144 R144 Biomuta DOID:3571 / liver cancer [ cosmic ]
K218 R218 Biomuta DOID:4159 / skin cancer [ cosmic ]
S256 L256 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ] DOID:9256 / colorectal cancer [ cosmic, icgc ]