iPTMnet Report for Q8WUY3 (PRUNE2)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q8WUY3 / PRUN2_HUMAN
Protein Name Protein prune homolog 2
Gene Name Name: PRUNE2
Synonyms:BMCC1,BNIPXL,C9orf65,KIAA0367;
Organism Homo sapiens (Human)

PRO ID PR:Q8WUY3
DAG View
PRO Name protein prune homolog 2 (human)
Definition A protein prune homolog 2 that is encoded in the genome of human.
Short Label hPRUNE2
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q8WUY3 (PRUNE2) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
M1 Acetylation UniProt 22814378
S110 Phosphorylation PhosphoSitePlus
S171 Phosphorylation PhosphoSitePlus
S562 Phosphorylation PhosphoSitePlus
S576 Phosphorylation PhosphoSitePlus
S581 Phosphorylation PhosphoSitePlus
S586 Phosphorylation PhosphoSitePlus
T588 Phosphorylation PhosphoSitePlus
S595 Phosphorylation PhosphoSitePlus
S597 Phosphorylation PhosphoSitePlus
S692 Phosphorylation PhosphoSitePlus
S699 Phosphorylation PhosphoSitePlus
S737 Phosphorylation PhosphoSitePlus
S918 Phosphorylation PhosphoSitePlus
S1024 Phosphorylation PhosphoSitePlus
S1211 Phosphorylation PhosphoSitePlus
T1262 Phosphorylation PhosphoSitePlus
S1264 Phosphorylation PhosphoSitePlus
S1420 Phosphorylation PhosphoSitePlus
S1440 Phosphorylation PhosphoSitePlus
S1613 Phosphorylation PhosphoSitePlus
S1670 Phosphorylation PhosphoSitePlus
S1719 Phosphorylation PhosphoSitePlus
S1723 Phosphorylation PhosphoSitePlus
Y1738 Phosphorylation PhosphoSitePlus
Y1740 Phosphorylation PhosphoSitePlus
S1744 Phosphorylation PhosphoSitePlus
S1789 Phosphorylation PhosphoSitePlus
T1792 Phosphorylation PhosphoSitePlus
T1795 Phosphorylation PhosphoSitePlus
S1803 Phosphorylation PhosphoSitePlus
S1842 Phosphorylation PhosphoSitePlus
S1849 Phosphorylation PhosphoSitePlus
T2091 Phosphorylation PhosphoSitePlus
Y2147 Phosphorylation PhosphoSitePlus
S2189 Phosphorylation PhosphoSitePlus
S2193 Phosphorylation PhosphoSitePlus
S2200 Phosphorylation PhosphoSitePlus
T2201 Phosphorylation PhosphoSitePlus
S2211 Phosphorylation PhosphoSitePlus
S2325 Phosphorylation PhosphoSitePlus
T2331 Phosphorylation PhosphoSitePlus
S2384 Phosphorylation PhosphoSitePlus
S2439 Phosphorylation PhosphoSitePlus
S2453 Phosphorylation PhosphoSitePlus
Y2550 Phosphorylation PhosphoSitePlus
S2866 Phosphorylation PhosphoSitePlus
Y2945 Phosphorylation PhosphoSitePlus
Y2958 Phosphorylation PhosphoSitePlus
T2967 Phosphorylation PhosphoSitePlus
K2980 Methylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S576 N576 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]
S576 I576 Biomuta DOID:3571 / liver cancer [ cosmic, icgc ]
S581 C581 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
S581 Y581 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
T588 R588 Biomuta DOID:3571 / liver cancer [ cosmic ]
S597 F597 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S737 N737 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S918 F918 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S1024 R1024 Biomuta DOID:1324 / lung cancer [ cosmic ]
S1211 I1211 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
T1262 N1262 Biomuta DOID:363 / uterine cancer [ icgc ]
S1264 F1264 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S1440 A1440 Biomuta DOID:363 / uterine cancer [ icgc ]
S1613 G1613 Biomuta DOID:3571 / liver cancer [ cosmic ]
S1723 F1723 Biomuta DOID:363 / uterine cancer [ icgc ]
S1789 F1789 Biomuta DOID:4159 / skin cancer [ cosmic ]
T2091 M2091 Biomuta DOID:2394 / ovarian cancer [ cosmic ]
S2189 L2189 Biomuta DOID:9253 / gastrointestinal stromal tumor [ cosmic ]
S2200 G2200 Biomuta DOID:263 / kidney cancer [ cosmic, icgc ]
S2325 F2325 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ] DOID:1612 / breast cancer [ cosmic ]
S2384 Y2384 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ] DOID:4159 / skin cancer [ cosmic ]
S2439 I2439 Biomuta DOID:4606 / bile duct cancer [ cosmic ] DOID:1324 / lung cancer [ icgc ] DOID:2531 / hematologic cancer [ cosmic, icgc ]
S2866 P2866 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
K2980 R2980 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]