iPTMnet Report for Q8WUA4 (GTF3C2)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q8WUA4 / TF3C2_HUMAN
Protein Name General transcription factor 3C polypeptide 2
Gene Name Name: GTF3C2
Synonyms:KIAA0011;
Organism Homo sapiens (Human)

PRO ID PR:Q8WUA4
DAG View
PRO Name general transcription factor 3C polypeptide 2 (human)
Definition A general transcription factor 3C polypeptide 2 that is encoded in the genome of human.
Short Label hGTF3C2
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q8WUA4 (GTF3C2) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S25 Phosphorylation PhosphoSitePlus
K37 Sumoylation PhosphoSitePlus
S39 Phosphorylation PhosphoSitePlus
S48 Phosphorylation PhosphoSitePlus
S63 Phosphorylation PhosphoSitePlus   UniProt 19690332, 24275569
S85 Phosphorylation PhosphoSitePlus
S132 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163
S136 Phosphorylation PhosphoSitePlus
T137 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S147 Phosphorylation PhosphoSitePlus
K148 Methylation PhosphoSitePlus
K155 Ubiquitination PhosphoSitePlus
S157 Phosphorylation PhosphoSitePlus
S165 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 16964243, 20068231
S167 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 21406692, 23186163, 16964243, ...18669648, 20068231, 17081983
T177 Phosphorylation PhosphoSitePlus
S219 Phosphorylation IEDB 32897882
S220 Phosphorylation IEDB   phospho.ELM   PhosphoSitePlus   UniProt 32897882, 21406692, 17081983, ...27869121
S260 Phosphorylation PhosphoSitePlus   UniProt 24275569
S264 Phosphorylation PhosphoSitePlus
S268 Phosphorylation PhosphoSitePlus
K315 Ubiquitination PhosphoSitePlus
K354 Ubiquitination PhosphoSitePlus
S379 Phosphorylation PhosphoSitePlus
T486 Phosphorylation PhosphoSitePlus
K489 Ubiquitination PhosphoSitePlus
C503 Methylation IEDB 31844290
S504 Phosphorylation PhosphoSitePlus
S597 Phosphorylation PhosphoSitePlus   UniProt 23186163
K602 Ubiquitination PhosphoSitePlus
K623 Methylation PhosphoSitePlus
K639 Ubiquitination PhosphoSitePlus
Y647 Phosphorylation PhosphoSitePlus
K756 Ubiquitination PhosphoSitePlus
S765 Phosphorylation PhosphoSitePlus
K783 Ubiquitination PhosphoSitePlus
R831 Methylation PhosphoSitePlus
K839 Ubiquitination PhosphoSitePlus
S871 Phosphorylation PhosphoSitePlus   UniProt 23186163, 20068231
R876 Methylation PhosphoSitePlus
S892 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 21406692, 17081983, ...20068231
S893 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 17081983, 20068231, ...18220336
T895 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163, 19690332, ...17081983
S901 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163, 17081983, ...24275569
T903 Phosphorylation PhosphoSitePlus
S904 Phosphorylation PhosphoSitePlus
T910 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S25 Phosphorylation HPRD 20068231
S132 Phosphorylation HPRD 18669648, 20068231
T137 Phosphorylation HPRD 18669648
S165 Phosphorylation HPRD 16964243, 20068231
S167 Phosphorylation HPRD 17081983, 18452278, 19651622, ...18669648, 20068231, 16964243
S220 Phosphorylation HPRD 17081983, 20068231
T222 Phosphorylation HPRD 20068231
S597 Phosphorylation HPRD 20068231
S652 Phosphorylation HPRD 20068231
S765 Phosphorylation HPRD 20068231
S871 Phosphorylation HPRD 20068231
S892 Phosphorylation HPRD 19651622, 18669648, 20068231
S893 Phosphorylation HPRD 17322306, 18767875, 18452278, ...19651622, 18669648, 18707149, 19415658, 20068231
T895 Phosphorylation HPRD 17322306, 18767875, 18669648, ...19651622, 20068231
S901 Phosphorylation HPRD 18669648, 20068231


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S39 C39 Biomuta DOID:4362 / cervical cancer [ cosmic, icgc ]
S132 F132 Biomuta DOID:4159 / skin cancer [ cosmic ]
T137 I137 Biomuta DOID:4159 / skin cancer [ cosmic ]
S157 L157 Biomuta DOID:263 / kidney cancer [ cosmic, icgc ]
S167 Y167 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S220 I220 Biomuta DOID:8618 / oral cavity cancer [ cosmic ]
S264 I264 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
S379 L379 Biomuta DOID:3571 / liver cancer [ cosmic, icgc ]
S597 C597 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
K639 N639 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
Y647 * Biomuta DOID:3571 / liver cancer [ cosmic ]
K783 N783 Biomuta DOID:5041 / esophageal cancer [ cosmic ]
S871 F871 Biomuta DOID:363 / uterine cancer [ icgc ]
R876 H876 Biomuta DOID:8618 / oral cavity cancer [ cosmic ] DOID:9256 / colorectal cancer [ cosmic, icgc ] DOID:10534 / stomach cancer [ cosmic ]
R876 C876 Biomuta DOID:1612 / breast cancer [ cosmic ]
T910 N910 Biomuta DOID:3571 / liver cancer [ cosmic ]