Protein Information

Cytoscape View

UniProt AC / UniProt ID Q8WUA2 / PPIL4_HUMAN
Protein Name Peptidyl-prolyl cis-trans isomerase-like 4
Gene Name Name: PPIL4
Organism Homo sapiens (Human)

DAG View
PRO Name peptidyl-prolyl cis-trans isomerase-like 4 (human)
Definition A peptidyl-prolyl cis-trans isomerase-like 4 that is encoded in the genome of human.
Short Label hPPIL4
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species

Q8WUA2 (PPIL4) as Substrate

Site PTM Type PTM Enzyme Score Source PMID
R21 Methylation PhosphoSitePlus
R23 Methylation PhosphoSitePlus
K138 Ubiquitination PhosphoSitePlus
K146 Ubiquitination PhosphoSitePlus
S178 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 17322306, 21406692, 23186163, ...17081983, 18220336, 19664995, 18452278, 19651622, 18669648, 20166139, 19690332, 20068231
T182 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 20068231, 18669648, 17081983, ...24275569
S188 Phosphorylation HPRD   PhosphoSitePlus 20068231
K201 Sumoylation PhosphoSitePlus
K201 Ubiquitination PhosphoSitePlus
S204 Phosphorylation PhosphoSitePlus
K212 Sumoylation PhosphoSitePlus
K212 Ubiquitination PhosphoSitePlus
Y283 Phosphorylation PhosphoSitePlus
K296 Ubiquitination PhosphoSitePlus
K300 Ubiquitination PhosphoSitePlus
K345 Ubiquitination PhosphoSitePlus
K352 Ubiquitination PhosphoSitePlus
K362 Sumoylation PhosphoSitePlus
K362 Ubiquitination PhosphoSitePlus
S374 Phosphorylation PhosphoSitePlus
K375 Ubiquitination PhosphoSitePlus
C392 S-Nitrosylation dbSNO 26338901
S393 Phosphorylation PhosphoSitePlus
Y401 Phosphorylation PhosphoSitePlus
K405 Sumoylation PhosphoSitePlus
K405 Ubiquitination PhosphoSitePlus
Y412 Phosphorylation PhosphoSitePlus
Y420 Phosphorylation PhosphoSitePlus
R435 Methylation PhosphoSitePlus
R437 Methylation PhosphoSitePlus
R441 Methylation PhosphoSitePlus
K460 Acetylation PhosphoSitePlus
K460 Methylation PhosphoSitePlus
K460 Sumoylation PhosphoSitePlus
K460 Ubiquitination PhosphoSitePlus
Y466 Phosphorylation PhosphoSitePlus
S471 Phosphorylation PhosphoSitePlus   UniProt 23186163

PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
R23 H23 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]
K138 R138 Biomuta DOID:3963 / thyroid carcinoma [ cosmic, icgc ]
K146 R146 Biomuta DOID:3571 / liver cancer [ icgc ] DOID:0070003 / blastoma [ cosmic ]
S178 * Biomuta DOID:3571 / liver cancer [ icgc ]
S188 I188 Biomuta DOID:9256 / colorectal cancer [ icgc, tcga ] DOID:1909 / melanoma [ cosmic ]
K362 Q362 Biomuta DOID:363 / uterine cancer [ tcga ]
S374 P374 Biomuta DOID:3963 / thyroid carcinoma [ cosmic ]
R437 Q437 Biomuta DOID:363 / uterine cancer [ icgc, tcga ]
R441 Q441 Biomuta DOID:363 / uterine cancer [ tcga ] DOID:5041 / esophageal cancer [ icgc ]