Protein Information

Cytoscape View


UniProt AC / UniProt ID Q8TF76 / HASP_HUMAN
Protein Name Serine/threonine-protein kinase haspin
Gene Name Name: HASPIN
Synonyms:GSG2;
Organism Homo sapiens (Human)

PRO ID PR:Q8TF76
DAG View
PRO Name serine/threonine-protein kinase haspin (human)
Definition A serine/threonine-protein kinase haspin that is encoded in the genome of human.
Short Label hHASPIN
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q8TF76 (HASPIN) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S4 Phosphorylation PhosphoSitePlus
S10 Phosphorylation PhosphoSitePlus   RLIMS-P 21397507
S58 Phosphorylation PhosphoSitePlus   UniProt 19690332
S93 Phosphorylation Q96GD4 (AURKB) , PR:Q96GD4 (hAURKB) neXtProt   phospho.ELM   PRO   PhosphoSitePlus   Signor   UniProt 18669648, 21658950
T97 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648
K99 Ubiquitination PhosphoSitePlus
S108 Phosphorylation PR:Q96GD4 (hAURKB) , Q96GD4 (AURKB) PRO   PhosphoSitePlus   Signor 21658950
T110 Phosphorylation PhosphoSitePlus
T112 Phosphorylation PhosphoSitePlus
T128 Phosphorylation P06493 (CDK1) PhosphoSitePlus 24413556
S140 Phosphorylation PhosphoSitePlus
S143 Phosphorylation PR:Q96GD4 (hAURKB) , Q96GD4 (AURKB) neXtProt   phospho.ELM   PRO   PhosphoSitePlus   Signor   UniProt 18669648, 21658950
S147 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163
S151 Phosphorylation PhosphoSitePlus
S165 Phosphorylation PhosphoSitePlus
S174 Phosphorylation PhosphoSitePlus
S179 Phosphorylation PhosphoSitePlus
S185 Phosphorylation PhosphoSitePlus
S188 Phosphorylation PhosphoSitePlus
T191 Phosphorylation PhosphoSitePlus
S192 Phosphorylation PhosphoSitePlus
S211 Phosphorylation PhosphoSitePlus
S216 Phosphorylation PhosphoSitePlus
S220 Phosphorylation phospho.ELM   PhosphoSitePlus 17525332
K229 Ubiquitination PhosphoSitePlus
T231 Phosphorylation PhosphoSitePlus
S240 Phosphorylation PhosphoSitePlus
S243 Phosphorylation PhosphoSitePlus
S251 Phosphorylation PhosphoSitePlus
T253 Phosphorylation phospho.ELM   PhosphoSitePlus 16565220
S269 Phosphorylation PhosphoSitePlus
K274 Ubiquitination PhosphoSitePlus
S287 Phosphorylation PhosphoSitePlus
S288 Phosphorylation PhosphoSitePlus
T289 Phosphorylation PhosphoSitePlus
K291 Ubiquitination PhosphoSitePlus
T295 Phosphorylation PhosphoSitePlus
S299 O-Glycosylation GlyGen 29351928
S317 Phosphorylation PhosphoSitePlus
S340 Phosphorylation PhosphoSitePlus
K341 Ubiquitination PhosphoSitePlus
S349 Phosphorylation PhosphoSitePlus
S366 Phosphorylation PhosphoSitePlus
T373 Phosphorylation PhosphoSitePlus
S387 Phosphorylation PhosphoSitePlus
S389 Phosphorylation PhosphoSitePlus
T429 Phosphorylation PhosphoSitePlus
S430 Phosphorylation PhosphoSitePlus
S434 Phosphorylation PhosphoSitePlus
S435 Phosphorylation PhosphoSitePlus
S445 Phosphorylation PhosphoSitePlus
S453 Phosphorylation PhosphoSitePlus
K462 Ubiquitination PhosphoSitePlus
K470 Ubiquitination PhosphoSitePlus
K483 Ubiquitination PhosphoSitePlus
K584 Ubiquitination PhosphoSitePlus
K618 Ubiquitination PhosphoSitePlus
S621 Phosphorylation PhosphoSitePlus
K664 Ubiquitination PhosphoSitePlus
K759 Methylation PhosphoSitePlus
T764 Phosphorylation PhosphoSitePlus
K768 Ubiquitination PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S93 Phosphorylation HPRD 18669648, 20068231
T97 Phosphorylation HPRD 18669648, 20068231
S143 Phosphorylation HPRD 18669648, 20068231
S147 Phosphorylation HPRD 18669648, 19664994
S216 Phosphorylation HPRD 19691289
S220 Phosphorylation HPRD 17525332
T253 Phosphorylation HPRD 16565220
S287 Phosphorylation HPRD 20068231
S288 Phosphorylation HPRD 20068231
T289 Phosphorylation HPRD 20068231


Proteoforms

PRO ID (Short Label) Sites PTM Enzyme Source PMID
PR:000035521 (hHASPIN/Phos:1) pS93,pS108,pS143 PR:Q96GD4 (hAURKB) PRO 21658950


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S4 W4 Biomuta DOID:11054 / urinary bladder cancer [ tcga ]
S93 C93 Biomuta DOID:3963 / thyroid carcinoma [ cosmic, icgc ]
S93 R93 Biomuta DOID:3963 / thyroid carcinoma [ cosmic ]
S165 N165 Biomuta DOID:1324 / lung cancer [ cosmic ]
S185 I185 Biomuta DOID:363 / uterine cancer [ tcga ]
S216 Y216 Biomuta DOID:363 / uterine cancer [ cosmic, icgc, tcga ]
S269 Y269 Biomuta DOID:363 / uterine cancer [ tcga ]
S366 L366 Biomuta DOID:363 / uterine cancer [ tcga ] DOID:10283 / prostate cancer [ cosmic ]
S389 G389 Biomuta DOID:363 / uterine cancer [ tcga ]