Protein Information

Cytoscape View


UniProt AC / UniProt ID Q8TF46 / DI3L1_HUMAN
Protein Name DIS3-like exonuclease 1
Gene Name Name: DIS3L
Synonyms:DIS3L1,KIAA1955;
Organism Homo sapiens (Human)

PRO ID PR:Q8TF46
DAG View
PRO Name DIS3-like exonuclease 1 (human)
Definition A DIS3-like exonuclease 1 that is encoded in the genome of human.
Short Label hDIS3L
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q8TF46 (DIS3L) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K108 Ubiquitination PhosphoSitePlus
K137 Ubiquitination PhosphoSitePlus
K223 Ubiquitination PhosphoSitePlus
K239 Ubiquitination PhosphoSitePlus
K252 Ubiquitination PhosphoSitePlus
K269 Ubiquitination PhosphoSitePlus
K283 Ubiquitination PhosphoSitePlus
K340 Ubiquitination PhosphoSitePlus
T348 Phosphorylation PhosphoSitePlus
S351 Phosphorylation PhosphoSitePlus
K352 Ubiquitination PhosphoSitePlus
S357 Phosphorylation PhosphoSitePlus
K364 Ubiquitination PhosphoSitePlus
T368 Phosphorylation PhosphoSitePlus
K470 Ubiquitination PhosphoSitePlus
S471 Phosphorylation PhosphoSitePlus
K480 Ubiquitination PhosphoSitePlus
Y536 Phosphorylation PhosphoSitePlus
S544 Phosphorylation PhosphoSitePlus
K695 Ubiquitination PhosphoSitePlus
K727 Ubiquitination PhosphoSitePlus
K737 Ubiquitination PhosphoSitePlus
Y802 Phosphorylation PhosphoSitePlus
S803 Phosphorylation PhosphoSitePlus
K824 Ubiquitination PhosphoSitePlus
S829 Phosphorylation PhosphoSitePlus
K831 Ubiquitination PhosphoSitePlus
Y881 Phosphorylation PhosphoSitePlus
K898 Ubiquitination PhosphoSitePlus
K904 Ubiquitination PhosphoSitePlus
K906 Ubiquitination PhosphoSitePlus
K922 Ubiquitination PhosphoSitePlus
S988 Phosphorylation PhosphoSitePlus
S989 Phosphorylation PhosphoSitePlus   UniProt 23186163
K998 Ubiquitination PhosphoSitePlus
T1001 Phosphorylation PhosphoSitePlus
K1002 Ubiquitination PhosphoSitePlus
Y1022 Phosphorylation PhosphoSitePlus
T1028 Phosphorylation PhosphoSitePlus
Y1034 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K223 N223 Biomuta DOID:363 / uterine cancer [ tcga ]
K283 N283 Biomuta DOID:3571 / liver cancer [ icgc ]
T368 I368 Biomuta DOID:363 / uterine cancer [ tcga ]
K480 E480 Biomuta DOID:3571 / liver cancer [ icgc ] DOID:0070003 / blastoma [ cosmic ]
K824 E824 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc, tcga ]
K906 T906 Biomuta DOID:363 / uterine cancer [ tcga ]