iPTMnet Report for Q8TF05 (PPP4R1)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q8TF05 / PP4R1_HUMAN
Protein Name Serine/threonine-protein phosphatase 4 regulatory subunit 1
Gene Name Name: PPP4R1
Synonyms:MEG1,PP4R1;
Organism Homo sapiens (Human)

PRO ID PR:Q8TF05
DAG View
PRO Name serine/threonine-protein phosphatase 4 regulatory subunit 1 (human)
Definition A serine/threonine-protein phosphatase 4 regulatory subunit 1 that is encoded in the genome of human.
Short Label hPPP4R1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q8TF05 (PPP4R1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K53 Ubiquitination PhosphoSitePlus
Y139 Phosphorylation PhosphoSitePlus
K199 Ubiquitination PhosphoSitePlus
S338 Phosphorylation PhosphoSitePlus
Y453 Phosphorylation PhosphoSitePlus
S455 Phosphorylation PhosphoSitePlus
S496 Phosphorylation PhosphoSitePlus
S538 Phosphorylation PhosphoSitePlus
S547 Phosphorylation PhosphoSitePlus
K550 Ubiquitination PhosphoSitePlus
C566 S-Nitrosylation dbSNO 26338901
S593 Phosphorylation PhosphoSitePlus
K612 Ubiquitination PhosphoSitePlus
K643 Ubiquitination PhosphoSitePlus
K730 Ubiquitination PhosphoSitePlus
K803 Ubiquitination PhosphoSitePlus
S806 Phosphorylation PhosphoSitePlus
T816 Phosphorylation PhosphoSitePlus
K887 Ubiquitination PhosphoSitePlus
T892 Phosphorylation PhosphoSitePlus
K926 Ubiquitination PhosphoSitePlus
S935 Phosphorylation PhosphoSitePlus   UniProt 23186163
K937 Ubiquitination PhosphoSitePlus
S944 Phosphorylation PhosphoSitePlus
T945 Phosphorylation PhosphoSitePlus
S947 Phosphorylation PhosphoSitePlus
S948 Phosphorylation PhosphoSitePlus
Y950 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S69 Phosphorylation HPRD 18767875
T73 Phosphorylation HPRD 18767875
S935 Phosphorylation HPRD 19651622
S944 Phosphorylation HPRD 19651622
T945 Phosphorylation HPRD 19651622
S947 Phosphorylation HPRD 19651622, 20068231
S948 Phosphorylation HPRD 19651622, 20068231
Site PTM Type PTM Enzyme Score Source PMID
S52 Phosphorylation HPRD 18767875
T56 Phosphorylation HPRD 18767875
S918 Phosphorylation HPRD 19651622
S927 Phosphorylation HPRD 19651622
T928 Phosphorylation HPRD 19651622
S930 Phosphorylation HPRD 19651622, 20068231
S931 Phosphorylation HPRD 19651622, 20068231


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K53 T53 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
Y453 C453 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S538 G538 Biomuta DOID:1324 / lung cancer [ cosmic ]
S593 N593 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ] DOID:1324 / lung cancer [ cosmic, icgc ] DOID:1781 / thyroid gland cancer [ cosmic ] DOID:2531 / hematologic cancer [ icgc ] DOID:1781 / thyroid cancer [ icgc ]
K643 E643 Biomuta DOID:5041 / esophageal cancer [ cosmic ]
K937 N937 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]