Protein Information

Cytoscape View


UniProt AC / UniProt ID Q8TEW6 / DOK4_HUMAN
Protein Name Docking protein 4
Gene Name Name: DOK4
Organism Homo sapiens (Human)

PRO ID PR:Q8TEW6
DAG View
PRO Name docking protein 4 (human)
Definition A docking protein 4 that is encoded in the genome of human.
Short Label hDOK4
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q8TEW6 (DOK4) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
Y13 Phosphorylation PhosphoSitePlus
S35 Phosphorylation PhosphoSitePlus
K66 Ubiquitination PhosphoSitePlus
Y104 Phosphorylation PhosphoSitePlus
T106 Phosphorylation PhosphoSitePlus
Y165 Phosphorylation PhosphoSitePlus
Y220 Phosphorylation PhosphoSitePlus
S225 Phosphorylation HPRD   PhosphoSitePlus 19664994
Y255 Phosphorylation PhosphoSitePlus
S256 Phosphorylation PhosphoSitePlus
Y257 Phosphorylation PhosphoSitePlus
T260 Phosphorylation PhosphoSitePlus
S314 Phosphorylation PhosphoSitePlus
S319 Phosphorylation PhosphoSitePlus
T323 Phosphorylation PhosphoSitePlus


PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation P00533 (EGFR) Y1016 Q8TEW6 (DOK4) unknown eFIP 16273093
Phosphorylation P04626 (ERBB2) Y1221 Q8TEW6 (DOK4) unknown eFIP 16273093


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S35 Y35 Biomuta DOID:3571 / liver cancer [ icgc ]
Y220 C220 Biomuta DOID:363 / uterine cancer [ tcga ]