iPTMnet Report for Q8TEU7 (RAPGEF6)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q8TEU7 / RPGF6_HUMAN
Protein Name Rap guanine nucleotide exchange factor 6
Gene Name Name: RAPGEF6
Synonyms:PDZGEF2;
Organism Homo sapiens (Human)

PRO ID PR:Q8TEU7
DAG View
PRO Name Rap guanine nucleotide exchange factor 6 (human)
Definition A Rap guanine nucleotide exchange factor 6 that is encoded in the genome of human.
Short Label hRAPGEF6
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q8TEU7 (RAPGEF6) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
M1 Acetylation UniProt 22814378
S3 Phosphorylation PhosphoSitePlus   UniProt 23186163
T27 Phosphorylation PhosphoSitePlus
Y29 Phosphorylation PhosphoSitePlus
S30 Phosphorylation PhosphoSitePlus
Y55 Phosphorylation PhosphoSitePlus
Y58 Phosphorylation PhosphoSitePlus
S138 Phosphorylation PhosphoSitePlus
Y147 Phosphorylation PhosphoSitePlus
Y163 Phosphorylation PhosphoSitePlus
S165 Phosphorylation PhosphoSitePlus
S230 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
K362 Ubiquitination PhosphoSitePlus
K385 Ubiquitination PhosphoSitePlus
K389 Ubiquitination PhosphoSitePlus
T496 Phosphorylation PhosphoSitePlus
T509 Phosphorylation PhosphoSitePlus
K510 Ubiquitination PhosphoSitePlus
K525 Ubiquitination PhosphoSitePlus
K535 Ubiquitination PhosphoSitePlus
K566 Ubiquitination PhosphoSitePlus
K573 Ubiquitination PhosphoSitePlus
K626 Ubiquitination PhosphoSitePlus
S644 Phosphorylation PhosphoSitePlus
K659 Ubiquitination PhosphoSitePlus
S661 Phosphorylation PhosphoSitePlus
S705 Phosphorylation PhosphoSitePlus
C763 Methylation IEDB 31844290
K817 Ubiquitination PhosphoSitePlus
S841 Phosphorylation PhosphoSitePlus
K890 Ubiquitination PhosphoSitePlus
K894 Ubiquitination PhosphoSitePlus
K932 Ubiquitination PhosphoSitePlus
T968 Phosphorylation PhosphoSitePlus
Y976 Phosphorylation PhosphoSitePlus
K978 Ubiquitination PhosphoSitePlus
K1018 Ubiquitination PhosphoSitePlus
K1039 Ubiquitination PhosphoSitePlus
T1054 Phosphorylation PhosphoSitePlus
S1055 Phosphorylation PhosphoSitePlus
S1068 Phosphorylation PhosphoSitePlus
S1070 Phosphorylation phospho.ELM   PhosphoSitePlus 17525332
S1073 Phosphorylation PhosphoSitePlus
T1074 Phosphorylation PhosphoSitePlus
S1076 Phosphorylation PhosphoSitePlus
S1093 Phosphorylation PhosphoSitePlus
S1094 Phosphorylation PhosphoSitePlus
Y1102 Phosphorylation PhosphoSitePlus
K1110 Ubiquitination PhosphoSitePlus
K1112 Ubiquitination PhosphoSitePlus
Y1138 Phosphorylation PhosphoSitePlus
T1140 Phosphorylation PhosphoSitePlus
S1154 Phosphorylation PhosphoSitePlus
S1157 Phosphorylation PhosphoSitePlus
T1168 Phosphorylation PhosphoSitePlus
K1169 Ubiquitination PhosphoSitePlus
S1179 Phosphorylation PhosphoSitePlus
K1195 Acetylation PhosphoSitePlus
T1205 O-Glycosylation GlyGen 31373491
S1206 Phosphorylation PhosphoSitePlus
K1221 Ubiquitination PhosphoSitePlus
S1237 Phosphorylation PhosphoSitePlus
S1241 Phosphorylation PhosphoSitePlus
S1245 Phosphorylation PhosphoSitePlus
Y1250 Phosphorylation PhosphoSitePlus
S1262 Phosphorylation PhosphoSitePlus
S1280 Phosphorylation PhosphoSitePlus
S1294 Phosphorylation PhosphoSitePlus
K1330 Ubiquitination PhosphoSitePlus
S1378 Phosphorylation PhosphoSitePlus
K1383 Ubiquitination PhosphoSitePlus
S1384 Phosphorylation PhosphoSitePlus
Y1391 Phosphorylation PhosphoSitePlus
T1406 Phosphorylation PhosphoSitePlus
S1408 Phosphorylation PhosphoSitePlus
Y1411 Phosphorylation PhosphoSitePlus
S1412 Phosphorylation PhosphoSitePlus
S1414 Phosphorylation PhosphoSitePlus
K1415 Ubiquitination PhosphoSitePlus
K1425 Ubiquitination PhosphoSitePlus
S1427 Phosphorylation PhosphoSitePlus
K1431 Ubiquitination PhosphoSitePlus
S1432 Phosphorylation PhosphoSitePlus
T1434 Phosphorylation PhosphoSitePlus
S1438 Phosphorylation PhosphoSitePlus
T1442 Phosphorylation PhosphoSitePlus
Y1443 Phosphorylation PhosphoSitePlus
Y1447 Phosphorylation PhosphoSitePlus
T1449 Phosphorylation PhosphoSitePlus
T1458 Phosphorylation PhosphoSitePlus
S1463 O-Glycosylation GlyGen 30379171, 31373491, 30620550
K1469 Acetylation PhosphoSitePlus
K1469 Ubiquitination PhosphoSitePlus
T1472 Phosphorylation PhosphoSitePlus
Y1476 Phosphorylation PhosphoSitePlus
K1477 Ubiquitination PhosphoSitePlus
T1478 Phosphorylation PhosphoSitePlus
Y1490 Phosphorylation PhosphoSitePlus
T1493 Phosphorylation PhosphoSitePlus
S1494 Phosphorylation phospho.ELM   PhosphoSitePlus 15302935
Y1501 Phosphorylation PhosphoSitePlus
T1507 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
K1520 Ubiquitination PhosphoSitePlus
T1525 Phosphorylation PhosphoSitePlus
K1528 Ubiquitination PhosphoSitePlus
S1533 Phosphorylation PhosphoSitePlus
K1540 Ubiquitination PhosphoSitePlus
S1545 Phosphorylation PhosphoSitePlus
S1553 O-Glycosylation GlyGen 31373491
S1556 O-Glycosylation GlyGen 30379171, 31373491, 30620550
T1586 Phosphorylation PhosphoSitePlus
S1590 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
T153 Phosphorylation HPRD 18452278
Y163 Phosphorylation HPRD 18452278
S230 Phosphorylation HPRD 19651622, 18669648, 18452278
T496 Phosphorylation HPRD 17081983
S1070 Phosphorylation HPRD 17525332
S1093 Phosphorylation HPRD 19651622, 20068231
S1094 Phosphorylation HPRD 17322306, 18767875, 19651622, ...18212344, 20068231
T1168 Phosphorylation HPRD 17081983
S1494 Phosphorylation HPRD 15302935
Y1501 Phosphorylation HPRD 15570572
T1507 Phosphorylation HPRD 18669648
S1590 Phosphorylation HPRD 19413330, 18691976
Site PTM Type PTM Enzyme Score Source PMID
S1362 Phosphorylation PhosphoSitePlus
S1367 Phosphorylation PhosphoSitePlus
S1373 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
T27 N27 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ] DOID:10534 / stomach cancer [ cosmic, icgc ]
S230 Y230 Biomuta DOID:3571 / liver cancer [ cosmic ]
K385 N385 Biomuta DOID:1793 / pancreatic cancer [ cosmic ]
K389 T389 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
T496 N496 Biomuta DOID:3571 / liver cancer [ cosmic ]
T496 A496 Biomuta DOID:363 / uterine cancer [ icgc ]
S705 I705 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
Y976 C976 Biomuta DOID:2394 / ovarian cancer [ cosmic, icgc ]
Y976 N976 Biomuta DOID:1793 / pancreatic cancer [ cosmic ]
S1055 Y1055 Biomuta DOID:363 / uterine cancer [ icgc ]
S1157 F1157 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S1179 G1179 Biomuta DOID:4159 / skin cancer [ cosmic ]
T1205 S1205 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
S1241 F1241 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S1294 F1294 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S1362 N1362 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S1378 N1378 Biomuta DOID:1319 / brain cancer [ cosmic, icgc ]
S1384 C1384 Biomuta DOID:4606 / bile duct cancer [ cosmic ]
S1412 F1412 Biomuta DOID:4159 / skin cancer [ cosmic ]
S1414 C1414 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
K1425 N1425 Biomuta DOID:3571 / liver cancer [ cosmic ]
K1425 T1425 Biomuta DOID:2394 / ovarian cancer [ cosmic ]
S1438 Y1438 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
T1442 A1442 Biomuta DOID:4362 / cervical cancer [ icgc ]
T1442 M1442 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
T1449 P1449 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
Y1490 C1490 Biomuta DOID:9256 / colorectal cancer [ cosmic ] DOID:1324 / lung cancer [ cosmic, icgc ]
T1493 I1493 Biomuta DOID:2531 / hematologic cancer [ cosmic, icgc ]
Y1501 H1501 Biomuta DOID:3571 / liver cancer [ cosmic ]