iPTMnet Report for Q8TER5 (ARHGEF40)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q8TER5 / ARH40_HUMAN
Protein Name Rho guanine nucleotide exchange factor 40
Gene Name Name: ARHGEF40
Synonyms:SOLO;
Organism Homo sapiens (Human)

PRO ID PR:Q8TER5
DAG View
PRO Name Rho guanine nucleotide exchange factor 40 (human)
Definition A Rho guanine nucleotide exchange factor 40 that is encoded in the genome of human.
Short Label hARHGEF40
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q8TER5 (ARHGEF40) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K56 Ubiquitination PhosphoSitePlus
K189 Ubiquitination PhosphoSitePlus
S226 Phosphorylation PhosphoSitePlus
Y242 Phosphorylation PhosphoSitePlus
S255 Phosphorylation PhosphoSitePlus
S262 Phosphorylation PhosphoSitePlus   UniProt 19369195, 24275569
T270 Phosphorylation PhosphoSitePlus
K293 Ubiquitination PhosphoSitePlus
T371 Phosphorylation PhosphoSitePlus   UniProt 24275569
R388 Methylation PhosphoSitePlus
S397 Phosphorylation PhosphoSitePlus
S401 Phosphorylation PhosphoSitePlus
S419 Phosphorylation PhosphoSitePlus   UniProt 24275569
S421 Phosphorylation PhosphoSitePlus
T495 Phosphorylation PhosphoSitePlus
T497 Phosphorylation PhosphoSitePlus
S806 Phosphorylation PhosphoSitePlus
S828 Phosphorylation PhosphoSitePlus
K852 Ubiquitination PhosphoSitePlus
S866 Phosphorylation PhosphoSitePlus
S931 Phosphorylation PhosphoSitePlus   UniProt 23186163
S961 Phosphorylation PhosphoSitePlus   UniProt 23186163
R963 Methylation PhosphoSitePlus
R966 Methylation PhosphoSitePlus
R983 Methylation PhosphoSitePlus
S986 Phosphorylation PhosphoSitePlus
S996 Phosphorylation PhosphoSitePlus
R1062 Methylation PhosphoSitePlus
R1064 Methylation PhosphoSitePlus
T1074 Phosphorylation PhosphoSitePlus
S1082 Phosphorylation PhosphoSitePlus   UniProt 21406692
S1187 Phosphorylation PhosphoSitePlus
K1191 Ubiquitination PhosphoSitePlus
S1193 Phosphorylation PhosphoSitePlus
Y1199 Phosphorylation PhosphoSitePlus
S1301 Phosphorylation PhosphoSitePlus
T1321 Phosphorylation PhosphoSitePlus
S1388 Phosphorylation PhosphoSitePlus
K1394 Ubiquitination PhosphoSitePlus
T1406 Phosphorylation PhosphoSitePlus
S1408 Phosphorylation PhosphoSitePlus
T1412 Phosphorylation PhosphoSitePlus
S1433 Phosphorylation PhosphoSitePlus   UniProt 24275569
S1438 Phosphorylation PhosphoSitePlus   UniProt 24275569
S1443 Phosphorylation PhosphoSitePlus
S1469 Phosphorylation PhosphoSitePlus
S1470 Phosphorylation PhosphoSitePlus
S1474 Phosphorylation PhosphoSitePlus   UniProt 24275569
S1480 Phosphorylation PhosphoSitePlus
S1490 Phosphorylation PhosphoSitePlus
S1491 Phosphorylation PhosphoSitePlus
T1492 Phosphorylation PhosphoSitePlus   UniProt 23186163
S1504 Phosphorylation PhosphoSitePlus
S1513 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S262 Phosphorylation HPRD 19413330, 19664994, 19664995
S421 Phosphorylation HPRD 19651622
S931 Phosphorylation HPRD 18669648, 19664994


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K189 E189 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
Y242 C242 Biomuta DOID:1319 / brain cancer [ cosmic ]
S255 R255 Biomuta DOID:1324 / lung cancer [ cosmic ]
T270 M270 Biomuta [ cosmic ]
T270 K270 Biomuta DOID:8618 / oral cavity cancer [ cosmic ] DOID:11934 / head and neck cancer [ icgc ]
K293 E293 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S397 N397 Biomuta DOID:184 / bone cancer [ cosmic ]
S419 L419 Biomuta DOID:4159 / skin cancer [ cosmic ]
S828 N828 Biomuta [ cosmic ]
R983 C983 Biomuta DOID:8618 / oral cavity cancer [ cosmic ]
S986 L986 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
R1062 L1062 Biomuta DOID:2531 / hematologic cancer [ cosmic, icgc, tcga ]
R1062 Q1062 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S1438 L1438 Biomuta DOID:1540 / parathyroid carcinoma [ cosmic ]