iPTMnet Report for Q8TEC5 (SH3RF2)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q8TEC5 / SH3R2_HUMAN
Protein Name E3 ubiquitin-protein ligase SH3RF2
Gene Name Name: SH3RF2
Synonyms:POSH3;
Organism Homo sapiens (Human)

PRO ID PR:Q8TEC5
DAG View
PRO Name E3 ubiquitin-protein ligase SH3RF2 (human)
Definition An E3 ubiquitin-protein ligase SH3RF2 that is encoded in the genome of human.
Short Label hSH3RF2
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q8TEC5 (SH3RF2) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
R84 Methylation PhosphoSitePlus
S112 Phosphorylation PhosphoSitePlus
K234 Ubiquitination PhosphoSitePlus
T425 Phosphorylation PhosphoSitePlus
S508 Phosphorylation PhosphoSitePlus
T642 Phosphorylation PhosphoSitePlus
S649 Phosphorylation PhosphoSitePlus
T657 Phosphorylation PhosphoSitePlus
S680 Phosphorylation PhosphoSitePlus
T686 Phosphorylation PhosphoSitePlus
S707 Phosphorylation PhosphoSitePlus
T713 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S112 T112 Biomuta DOID:1319 / brain cancer [ cosmic ]
T425 N425 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
T642 I642 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S680 F680 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ] DOID:9256 / colorectal cancer [ icgc ]
S707 P707 Biomuta DOID:9256 / colorectal cancer [ cosmic ]