iPTMnet Report for Q8TEA7 (TBCK)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q8TEA7 / TBCK_HUMAN
Protein Name TBC domain-containing protein kinase-like protein
Gene Name Name: TBCK
Synonyms:TBCKL;ORFNames:HSPC302;
Organism Homo sapiens (Human)

PRO ID PR:Q8TEA7
DAG View
PRO Name TBC domain-containing protein kinase-like protein (human)
Definition A TBC domain-containing protein kinase-like protein that is encoded in the genome of human.
Short Label hTBCK
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q8TEA7 (TBCK) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S118 Phosphorylation PhosphoSitePlus
Y153 Phosphorylation PhosphoSitePlus
T169 Phosphorylation PhosphoSitePlus
K271 Ubiquitination PhosphoSitePlus
K285 Ubiquitination PhosphoSitePlus
K343 Ubiquitination PhosphoSitePlus
K349 Ubiquitination PhosphoSitePlus
K433 Ubiquitination PhosphoSitePlus
K450 Ubiquitination PhosphoSitePlus
K456 Ubiquitination PhosphoSitePlus
K461 Ubiquitination PhosphoSitePlus
K495 Ubiquitination PhosphoSitePlus
R503 Methylation PhosphoSitePlus
K706 Ubiquitination PhosphoSitePlus
K718 Ubiquitination PhosphoSitePlus
Y732 Phosphorylation PhosphoSitePlus
K756 Ubiquitination PhosphoSitePlus
S757 Phosphorylation PhosphoSitePlus
S760 Phosphorylation PhosphoSitePlus
K881 Ubiquitination PhosphoSitePlus
S890 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
Y669 Phosphorylation HPRD 19901323
S827 Phosphorylation HPRD 19413330


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
T169 A169 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
K285 N285 Biomuta [ cosmic ] DOID:1319 / brain cancer [ cosmic ] DOID:8618 / oral cavity cancer [ cosmic ] DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ]
K349 R349 Biomuta DOID:4362 / cervical cancer [ cosmic ]
K450 M450 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
R503 I503 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S760 L760 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]