iPTMnet Report for Q8TEA1 (NSUN6)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q8TEA1 / NSUN6_HUMAN
Protein Name tRNA (cytosine(72)-C(5))-methyltransferase NSUN6
Gene Name Name: NSUN6
Synonyms:NOPD1;
Organism Homo sapiens (Human)

PRO ID PR:Q8TEA1
DAG View
PRO Name tRNA (cytosine(72)-C(5))-methyltransferase NSUN6 (human)
Definition A tRNA (cytosine(72)-C(5))-methyltransferase NSUN6 that is encoded in the genome of human.
Short Label hNSUN6
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q8TEA1 (NSUN6) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K6 Ubiquitination PhosphoSitePlus
K18 Ubiquitination PhosphoSitePlus
K32 Ubiquitination PhosphoSitePlus
K38 Ubiquitination PhosphoSitePlus
K68 Ubiquitination PhosphoSitePlus
K109 Ubiquitination PhosphoSitePlus
Y151 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 18083107
K155 Ubiquitination PhosphoSitePlus
K169 Ubiquitination PhosphoSitePlus
K182 Ubiquitination PhosphoSitePlus
K192 Ubiquitination PhosphoSitePlus
T199 Phosphorylation PhosphoSitePlus
S210 Phosphorylation PhosphoSitePlus
Y215 Phosphorylation PhosphoSitePlus
K248 Ubiquitination PhosphoSitePlus
K271 Acetylation PhosphoSitePlus
K271 Ubiquitination PhosphoSitePlus
K274 Acetylation PhosphoSitePlus
K276 Acetylation PhosphoSitePlus
K299 Ubiquitination PhosphoSitePlus
K342 Ubiquitination PhosphoSitePlus
K419 Acetylation PhosphoSitePlus   UniProt 19608861
K419 Ubiquitination PhosphoSitePlus
K453 Ubiquitination PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K6 N6 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
K68 E68 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
K155 N155 Biomuta DOID:10534 / stomach cancer [ cosmic ]
K271 N271 Biomuta DOID:10534 / stomach cancer [ cosmic ]
K453 N453 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]