iPTMnet Report for Q8TE60 (ADAMTS18)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q8TE60 / ATS18_HUMAN
Protein Name A disintegrin and metalloproteinase with thrombospondin motifs 18 precursor
Gene Name Name: ADAMTS18
Synonyms:ADAMTS21;
Organism Homo sapiens (Human)

PRO ID PR:Q8TE60
DAG View
PRO Name a disintegrin and metalloproteinase with thrombospondin motifs 18 (human)
Definition An a disintegrin and metalloproteinase with thrombospondin motifs 18 that is encoded in the genome of human.
Short Label hADAMTS18
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q8TE60 (ADAMTS18) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
Y99 Phosphorylation PhosphoSitePlus
K311 Acetylation PhosphoSitePlus
K330 Acetylation PhosphoSitePlus
S462 Phosphorylation PhosphoSitePlus
S475 O-Glycosylation GlyGen 29351928
Y755 Phosphorylation PhosphoSitePlus
Y764 Phosphorylation PhosphoSitePlus
Y765 Phosphorylation PhosphoSitePlus
Y788 Phosphorylation PhosphoSitePlus
S793 Phosphorylation PhosphoSitePlus
S795 Phosphorylation PhosphoSitePlus
S883 Phosphorylation PhosphoSitePlus
Y893 Phosphorylation PhosphoSitePlus
S1060 Phosphorylation PhosphoSitePlus
K1100 Sumoylation PhosphoSitePlus
K1101 Sumoylation PhosphoSitePlus
Y1209 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K330 N330 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
S475 Y475 Biomuta DOID:4159 / skin cancer [ cosmic ]
S475 F475 Biomuta DOID:4159 / skin cancer [ cosmic ]
S793 R793 Biomuta DOID:1324 / lung cancer [ cosmic ]
S793 T793 Biomuta DOID:8618 / oral cavity cancer [ cosmic ]
S795 N795 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
Y893 * Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S1060 L1060 Biomuta DOID:363 / uterine cancer [ icgc ] DOID:4159 / skin cancer [ cosmic, icgc, tcga ]
K1100 N1100 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
Y1209 * Biomuta DOID:3571 / liver cancer [ cosmic ] DOID:1324 / lung cancer [ cosmic ]