iPTMnet Report for Q8TDZ2 (MICAL1)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q8TDZ2 / MICA1_HUMAN
Protein Name [F-actin]-monooxygenase MICAL1
Gene Name Name: MICAL1
Synonyms:MICAL,NICAL;
Organism Homo sapiens (Human)

PRO ID PR:Q8TDZ2
DAG View
PRO Name [F-actin]-monooxygenase MICAL1 (human)
Definition An [F-actin]-monooxygenase MICAL1 that is encoded in the genome of human.
Short Label hMICAL1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q8TDZ2 (MICAL1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K52 Ubiquitination PhosphoSitePlus
K61 Ubiquitination PhosphoSitePlus
K66 Ubiquitination PhosphoSitePlus
K228 Ubiquitination PhosphoSitePlus
T241 Phosphorylation PhosphoSitePlus
Y265 Phosphorylation PhosphoSitePlus
S272 Phosphorylation PhosphoSitePlus
K348 Ubiquitination PhosphoSitePlus
S444 Phosphorylation PhosphoSitePlus
T446 Phosphorylation PhosphoSitePlus
S447 Phosphorylation PhosphoSitePlus
T475 Phosphorylation PhosphoSitePlus
Y483 Phosphorylation PhosphoSitePlus
K488 Ubiquitination PhosphoSitePlus
K497 Ubiquitination PhosphoSitePlus
T498 O-Glycosylation GlyGen 29351928
T498 Phosphorylation PhosphoSitePlus
T500 Phosphorylation PhosphoSitePlus
C544 Methylation IEDB 31844290
S613 Phosphorylation PhosphoSitePlus
S617 Phosphorylation PhosphoSitePlus   UniProt 23186163, 19690332
S622 Phosphorylation PhosphoSitePlus
S625 Phosphorylation PhosphoSitePlus
T628 Phosphorylation PhosphoSitePlus
S629 Phosphorylation PhosphoSitePlus
S630 Phosphorylation PhosphoSitePlus
S636 Phosphorylation PhosphoSitePlus
K637 Ubiquitination PhosphoSitePlus
T641 Phosphorylation PhosphoSitePlus
T683 Phosphorylation PhosphoSitePlus
C711 Methylation IEDB 31844290
S767 Phosphorylation PhosphoSitePlus
S809 Phosphorylation PhosphoSitePlus
S810 Phosphorylation PhosphoSitePlus
S817 Phosphorylation PhosphoSitePlus
S818 Phosphorylation PhosphoSitePlus
T822 Phosphorylation PhosphoSitePlus
S838 Phosphorylation PhosphoSitePlus
S848 Phosphorylation PhosphoSitePlus
S858 Phosphorylation PhosphoSitePlus
S872 Phosphorylation PhosphoSitePlus   UniProt 21406692, 17081983
S875 Phosphorylation PhosphoSitePlus   UniProt 21406692, 19690332
S876 Phosphorylation PhosphoSitePlus   UniProt 21406692, 19690332
Y906 Phosphorylation PhosphoSitePlus
T908 Phosphorylation PhosphoSitePlus
T912 Phosphorylation PhosphoSitePlus
K927 Ubiquitination PhosphoSitePlus
S960 Phosphorylation PhosphoSitePlus
S961 Phosphorylation PhosphoSitePlus
K1022 Ubiquitination PhosphoSitePlus
K1036 Ubiquitination PhosphoSitePlus
S1057 Phosphorylation PhosphoSitePlus   UniProt 23186163
Site PTM Type PTM Enzyme Score Source PMID
S444 Phosphorylation HPRD 18077418
T446 Phosphorylation HPRD 18077418
S447 Phosphorylation HPRD 18077418
S810 Phosphorylation HPRD 17081983
S872 Phosphorylation HPRD 17081983, 18452278
S875 Phosphorylation HPRD 17081983, 18452278
S876 Phosphorylation HPRD 17081983, 18452278


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K228 N228 Biomuta DOID:5041 / esophageal cancer [ cosmic ]
T446 A446 Biomuta DOID:1319 / brain cancer [ cosmic, icgc ]
K497 R497 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
S617 I617 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S625 F625 Biomuta DOID:4159 / skin cancer [ icgc ]
S961 N961 Biomuta DOID:4606 / bile duct cancer [ cosmic ]
S1057 N1057 Biomuta [ cosmic ] DOID:1115 / sarcoma [ icgc ]