iPTMnet Report for Q8TDY4 (ASAP3)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q8TDY4 / ASAP3_HUMAN
Protein Name Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 3
Gene Name Name: ASAP3
Synonyms:DDEFL1,UPLC1;
Organism Homo sapiens (Human)

PRO ID PR:Q8TDY4
DAG View
PRO Name Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 3 (human)
Definition An Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 3 that is encoded in the genome of human.
Short Label hASAP3
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q8TDY4 (ASAP3) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
Y34 Phosphorylation P00533 (EGFR) PhosphoSitePlus   RLIMS-P   Signor 23776207
Y76 Phosphorylation PhosphoSitePlus
K145 Ubiquitination PhosphoSitePlus
K152 Acetylation PhosphoSitePlus
K152 Ubiquitination PhosphoSitePlus
K157 Acetylation PhosphoSitePlus
K260 Ubiquitination PhosphoSitePlus
S286 Phosphorylation PhosphoSitePlus
K311 Acetylation PhosphoSitePlus
Y530 Phosphorylation PhosphoSitePlus
K534 Ubiquitination PhosphoSitePlus
Y535 Phosphorylation PhosphoSitePlus
T545 Phosphorylation Q9P289 (STK26) PhosphoSitePlus   RLIMS-P   Signor 28808054
K639 Ubiquitination PhosphoSitePlus
K643 Ubiquitination PhosphoSitePlus
S700 Phosphorylation PhosphoSitePlus
S723 Phosphorylation PhosphoSitePlus
Y733 Phosphorylation PhosphoSitePlus   RLIMS-P 22027826
T743 Phosphorylation PhosphoSitePlus
Y843 Phosphorylation PhosphoSitePlus
S862 Phosphorylation PhosphoSitePlus
S868 Phosphorylation PhosphoSitePlus
T890 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S143 Phosphorylation PhosphoSitePlus


PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation Q8TDY4 (ASAP3) Y733 P62993 (GRB2) unknown eFIP 22027826


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
Y535 C535 Biomuta DOID:4159 / skin cancer [ cosmic ]
Y843 C843 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ] DOID:1324 / lung cancer [ cosmic, icgc ]
S868 L868 Biomuta DOID:5041 / esophageal cancer [ cosmic ]