iPTMnet Report for Q8TDX7 (NEK7)
Protein Information
| UniProt AC / UniProt ID | Q8TDX7 / NEK7_HUMAN |
| Protein Name | Serine/threonine-protein kinase Nek7 |
| Gene Name | Name: NEK7 |
| Organism | Homo sapiens (Human) |
| PRO ID | PR:Q8TDX7 |
| PRO Name | serine/threonine-protein kinase Nek7 (human) |
| Definition | A serine/threonine-protein kinase Nek7 that is encoded in the genome of human. |
| Short Label | hNEK7 |
| Category | organism-gene |
DAG ViewQ8TDX7 (NEK7) as Substrate
 |
Site | PTM Type | PTM Enzyme | Score | Source | PMID |
|---|---|---|---|---|---|---|
| M1 | Acetylation | score1 | UniProt | 19413330 | ||
| S5 | Phosphorylation | score2 | PhosphoSitePlus UniProt | 23186163 | ||
| K20 | Ubiquitination | score1 | PhosphoSitePlus | |||
| T30 | Phosphorylation | score1 | PhosphoSitePlus | |||
| K63 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K64 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K74 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K81 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K87 | Ubiquitination | score1 | PhosphoSitePlus | |||
| Y97 | Phosphorylation | score4 | PhosphoSitePlus RLIMS-P | 26522158, 32242624 | ||
| S147 | Phosphorylation | score1 | PhosphoSitePlus | |||
| K163 | Ubiquitination | score1 | PhosphoSitePlus | |||
| T170 | Phosphorylation | score1 | PhosphoSitePlus | |||
| T172 | Phosphorylation | score1 | PhosphoSitePlus | |||
| K176 | Ubiquitination | score1 | PhosphoSitePlus | |||
| S187 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S188 | Phosphorylation | score1 | PhosphoSitePlus | |||
| K189 | Ubiquitination | score1 | PhosphoSitePlus | |||
| T190 | Phosphorylation | score1 | PhosphoSitePlus | |||
| T191 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S195 | Phosphorylation | Q8TD19 (NEK9) | score4 | phospho.ELM PRO PhosphoSitePlus RLIMS-P Signor UniProt | 12840024, 26522158, 32242624 | |
| T199 | Phosphorylation | score1 | PhosphoSitePlus | |||
| Y201 | Phosphorylation | score2 | phospho.ELM PhosphoSitePlus | 18669648 | ||
| Y202 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S204 | Phosphorylation | score2 | phospho.ELM PhosphoSitePlus | 18669648 | ||
| Y244 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S245 | Phosphorylation | score1 | PhosphoSitePlus | |||
| K248 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K249 | Ubiquitination | score1 | PhosphoSitePlus | |||
| S260 | O-Glycosylation | score1 | GlyGen | 29351928 | ||
| S264 | O-Glycosylation | score1 | GlyGen | 29351928 | ||
| K281 | Ubiquitination | score1 | PhosphoSitePlus | |||
| T286 | Phosphorylation | score1 | PhosphoSitePlus | |||
| Y287 | Phosphorylation | score1 | PhosphoSitePlus | |||
| Y289 | Phosphorylation | score1 | PhosphoSitePlus | |||
| K293 | Ubiquitination | score1 | PhosphoSitePlus |
|
Site | PTM Type | PTM Enzyme | Score | Source | PMID |
|---|---|---|---|---|---|---|
| S187 | Phosphorylation | score0 | HPRD | 18691976 | ||
| S188 | Phosphorylation | score0 | HPRD | 18691976 | ||
| T190 | Phosphorylation | score0 | HPRD | 18691976 | ||
| S195 | Phosphorylation | Q8TD19 (NEK9) | score2 | HPRD | 18691976, 12840024, 18452278 | |
| T199 | Phosphorylation | score0 | HPRD | 18691976 | ||
| Y201 | Phosphorylation | score0 | HPRD | 18691976, 18669648 | ||
| Y202 | Phosphorylation | score0 | HPRD | 18691976 | ||
| S204 | Phosphorylation | score0 | HPRD | 18691976, 18669648 |
Q8TDX7 (NEK7) as PTM Enzyme
|
Substrate | Site | Score | Source | PMID |
|---|---|---|---|---|---|
| P23443 (RPS6KB1) | T412 | score3 | neXtProt | 11516946, 12589797 | |
| P54274 (TERF1) | S114 | score2 | RLIMS-P+ | 28216227 | |
| Q15058 (KIF14) | S56 | score1 | Signor | 28630147 | |
| Q15058 (KIF14) | S607 | score1 | Signor | 28630147 | |
| Q15058 (KIF14) | S1217 | score1 | Signor | 28630147 | |
| Q15058 (KIF14) | S1219 | score1 | Signor | 28630147 | |
| Q15058 (KIF14) | S1220 | score1 | Signor | 28630147 |
PTM sites affected in variants
| Site | Variant | Source | PMID | Disease [Sample source] |
|---|---|---|---|---|
| K87 | E87 | Biomuta | DOID:4159 / skin cancer [ cosmic ] | |
| K163 | I163 | Biomuta | DOID:4159 / skin cancer [ cosmic ] | |
| S187 | G187 | Biomuta | DOID:9253 / gastrointestinal stromal tumor [ cosmic ] | |
| S195 | Y195 | Biomuta | DOID:363 / uterine cancer [ cosmic, icgc ] DOID:9256 / colorectal cancer [ cosmic, icgc ] | |
| T199 | R199 | Biomuta | DOID:363 / uterine cancer [ cosmic ] | |
| T199 | M199 | Biomuta | DOID:363 / uterine cancer [ cosmic, icgc ] DOID:9256 / colorectal cancer [ cosmic ] | |
| Y201 | H201 | Biomuta | DOID:263 / kidney cancer [ cosmic ] | |
| Y201 | * | Biomuta | DOID:9256 / colorectal cancer [ cosmic ] | |
| S204 | Y204 | Biomuta | DOID:4159 / skin cancer [ cosmic ] | |
| K248 | T248 | Biomuta | DOID:9256 / colorectal cancer [ cosmic ] | |
| K249 | N249 | Biomuta | DOID:263 / kidney cancer [ cosmic, icgc ] | |
| K293 | R293 | Biomuta | DOID:10283 / prostate cancer [ cosmic ] | |
| K293 | N293 | Biomuta | DOID:5041 / esophageal cancer [ cosmic ] |
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